Diagenode

Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Potent and selective bivalent inhibitors of BET bromodomains
Published: December, 2016

Abstract: Proteins of the bromodomain and extraterminal (BET) family, in particular bromodomain-containing protein 4 (BRD4), are of great interest as biologi... Read more »

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Antibody
Genome-wide DNA methylation analysis identifies MEGF10 as a novel e...
Published: November, 2016

Abstract: Neuroblastoma is a childhood cancer in which many children still have poor outcomes, emphasising the need to better understand its pathogenesis. De... Read more »
Genetic Drivers of Epigenetic and Transcriptional Variation in Huma...
Published: November, 2016

Abstract: Characterizing the multifaceted contribution of genetic and epigenetic factors to disease phenotypes is a major challenge in human genetics a... Read more »

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Antibody IP-Star Compact
Activation of GPER suppresses migration and angiogenesis of triple ...
Published: November, 2016

Abstract: Triple-negative breast cancer (TNBC) are characterized by high vascularity and frequent metastasis. Here, we found that activation of G protein-cou... Read more »
Enhanced CRISPR/Cas9-mediated precise genome editing by improved de...
Published: November, 2016

Abstract: While CRISPR-based gene knock out in mammalian cells has proven to be very efficient, precise insertion of genetic elements via the cellular homolo... Read more »

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Antibody
A set of novel automated quantitative microproteomics protocols for...
Published: November, 2016

Abstract: Here we assessed the ability of an automated sample preparation device equipped with disposable microcolumns to prepare mass-limited samples for hi... Read more »

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Bioruptor Mass Spectrometry
DNA methylation and alcohol use disorders: Progress and challenges
Published: October, 2016

Abstract: Background and Objectives Risk for alcohol use disorders (AUDs) is influenced by gene–environment interactions. Environmental factors can ... Read more »

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Premium RRBS Kit
Analysis of Cohesin Function in Gene Regulation and Chromatin Organ...
Published: October, 2016

Abstract: Cohesin is essential for the maintenance of chromosomes through the cell cycle. In addition, cohesin contributes to the regulation of gene expressi... Read more »
Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentia...
Published: October, 2016

Abstract: The transcription factor Foxo3 plays a crucial role in myeloid cell function but its role in lymphoid cells remains poorly defined. Here, we have s... Read more »
Chronic stress leads to epigenetic dysregulation in the neuropeptid...
Published: October, 2016

Abstract: Persistent stress triggers a variety of mechanisms, which may ultimately lead to the occurrence of anxiety- and depression-related disorders. Epige... Read more »

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Antibody
Regulation of transcriptional elongation in pluripotency and cell d...
Published: October, 2016

Abstract: Pluripotent embryonic stem cells (ESCs) self-renew or differentiate into all tissues of the developing embryo and cell-specification factors are ne... Read more »

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Antibody
In vivo conditional deletion of HDAC7 reveals its requirement to es...
Published: October, 2016

Abstract: Class IIa histone deacetylase (HDAC) subfamily members are tissue-specific gene repressors with crucial roles in development and differentiation pr... Read more »

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LowCell ChIP kit True MicroChIP kit
Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse E...
Published: October, 2016

Abstract: In human ESCs the transcription factor Zeb2 regulates neuroectoderm versus mesendoderm formation, but it is unclear how Zeb2 affects the global tra... Read more »

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Premium RRBS Kit
DNA fragmentation and quality control analysis
Published: September, 2016

Abstract: Optimal data generation using NGS platforms relies on a few sample-preparation prerequisites, namely, precise DNA fragmentation, size-range an... Read more »

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DNA shearing Bioruptor
The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 ...
Published: September, 2016

Abstract: Molecular classification of cancers into subtypes has resulted in an advance in our understanding of tumour biology and treatment response across m... Read more »

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HighCell ChIP kit IPure kit
Novel regional age-associated DNA methylation changes within human ...
Published: September, 2016

Abstract: BACKGROUND: Advancing age progressively impacts on risk and severity of chronic disease. It also modifies the epigenome, with changes in DNA met... Read more »

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MagMeDIP kit 5mC (C15200081)
Deficient expression of JMJD1A histone demethylase in patients with...
Published: September, 2016

Abstract: JMJD1A (jumonji domain-containing 1A), a known histone H3K9 demethylase, has been identified as a critical epigenetic regulator in male germ cells,... Read more »

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Histone ChIP kit
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted E...
Published: September, 2016

Abstract: Gene silencing is instrumental to interrogate gene function and holds promise for therapeutic applications. Here, we repurpose the endogenous retro... Read more »

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Bioruptor MagMeDIP kit IPure kit
Trichloroethylene-Induced DNA Methylation Changes in Male F344 Rat ...
Published: September, 2016

Abstract: Trichloroethylene (TCE), a common environmental contaminant, causes hepatocellular carcinoma in mice but not in rats. To understand the mechanisms ... Read more »

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MagMeDIP kit
Neonatal monocytes exhibit a unique histone modification landscape
Published: September, 2016

Abstract: Background Neonates have dampened expression of pro-inflammatory cytokines and difficulty clearing pathogens. This makes them uniquely susceptib... Read more »

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Antibody
BRD4 localization to lineage-specific enhancers is associated with ...
Published: September, 2016

Abstract: Proper temporal epigenetic regulation of gene expression is essential for cell fate determination and tissue development. The Bromodomain-containin... Read more »

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Antibody Microplex Library Preparation kit
Coordinate redeployment of PRC1 proteins suppresses tumor formation...
Published: September, 2016

Abstract: Polycomb group proteins form two main complexes, PRC2 and PRC1, which generally coregulate their target genes. Here we show that PRC1 components ac... Read more »

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Antibody
Overexpression of histone demethylase Fbxl10 leads to enhanced migr...
Published: September, 2016

Abstract: Cell migration is a central process in the development and maintenance of multicellular organisms. Tissue formation during embryonic development, w... Read more »

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Antibody
CTCF modulates Estrogen Receptor function through specific chromati...
Published: September, 2016

Abstract: Enhancer regions and transcription start sites of estrogen-target regulated genes are connected by means of Estrogen Receptor long-range chromatin ... Read more »

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Microplex Library Preparation kit
Heterochromatic histone modifications at transposons in Xenopus tro...
Published: September, 2016

Abstract: Transposable elements are parasitic genomic elements that can be deleterious for host gene function and genome integrity. Heterochromatic histone m... Read more »

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Antibody
Allelic reprogramming of the histone modification H3K4me3 in early ...
Published: September, 2016

Abstract: Histone modifications are fundamental epigenetic regulators that control many crucial cellular processes1. However, whether these marks can be pass... Read more »

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Antibody
Detection of Protein-Protein Interactions and Posttranslational Mod...
Published: September, 2016

Abstract: The detection of protein-protein interactions by imaging techniques often requires the overexpression of the proteins of interest tagged with fluor... Read more »

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Antibody
Condition-dependent co-regulation of genomic clusters of virulence ...
Published: September, 2016

Abstract: The ascomycete Neofusicoccum parvum, one of the causal agents of Botryosphaeria dieback, is a destructive wood-infecting fungus and a serious threa... Read more »

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Megaruptor
Esrrb directly binds to Gata6 promoter and regulates its expression...
Published: September, 2016

Abstract: Estrogen-related receptor beta (Esrrb) is expressed in embryonic stem (ES) cells and is involved in self-renewal ability and pluripotency. Previous... Read more »
Fumarate is an epigenetic modifier that elicits epithelial-to-mesen...
Published: August, 2016

Abstract: Mutations of the tricarboxylic acid cycle enzyme fumarate hydratase cause hereditary leiomyomatosis and renal cell cancer1. Fumarate hydratase-defi... Read more »

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Antibody

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