Diagenode

Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

CRISPR-Cas9 Structures and Mechanisms
Published: May, 2017

Abstract: Many bacterial CRISPR-Cas systems employ the dual-RNA-guided DNA endonuclease Cas9 to defend against invading phages and conjugative plasmids by in... Read more »

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Article alert
MeDIP-seq and nCpG analyses illuminate sexually dimorphic methylati...
Published: May, 2017

Abstract: Background DNA methylation alters gene expression but not DNA sequence and mediates some cases of phenotypic plasticity. Temperature-dependent s... Read more »

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MagMeDIP kit
Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcr...
Published: May, 2017

Abstract: Monocytes are circulating, short-lived mononuclear phagocytes, which in mice and man comprise two main subpopulations. MurineLy6C+ monocytes displa... Read more »

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Bioruptor
The adaptor protein ARA55 and the nuclear kinase HIPK1 assist c-Myb...
Published: May, 2017

Abstract: LIM-domain proteins, containing multiple cysteine-rich zinc finger-like motifs, have been shown to play diverse roles in several cellular processes... Read more »

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Bioruptor
PPARγ Links BMP2 and TGFβ1 Pathways in Vascular Smooth Muscle Cells...
Published: May, 2017

Abstract: BMP2 and TGFβ1 are functional antagonists of pathological remodeling in the arteries, heart, and lung; however, the mechanisms in VSMCs, and t... Read more »

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ChIP-seq IPure kit
sgs1: a neomorphic nac52 allele impairing PTGS through SGS3 down-re...
Published: May, 2017

Abstract: Post-transcriptional gene silencing (PTGS) is a defense mechanism that targets invading nucleic acids from endogenous (transposons) or exogenous (p... Read more »

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IPure kit
Novel Molecular Mechanism of Regulation of CD40 Ligand by the Trans...
Published: April, 2017

Abstract: The interaction between tumor cells and their surrounding microenvironment is essential for the growth and persistence of cancer cells. This intera... Read more »

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Bioruptor
Critical threshold levels of DNA methyltransferase 1 are required t...
Published: April, 2017

Abstract: Reversing DNA methylation abnormalities and associated gene silencing, through inhibiting DNA methyltransferases (DNMTs) is an important potential ... Read more »

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Antibody
DNA breaks and chromatin structural changes enhance the transcripti...
Published: April, 2017

Abstract: The autoimmune regulator (AIRE) protein is the key factor in thymic negative selection of autoreactive T cells by promoting the ectopic expression ... Read more »

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Antibody IP-Star Compact
Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Pro...
Published: April, 2017

Abstract: Transcription factors play a key role in the development of diverse cancers, and therapeutically targeting them has remained a challenge. In prosta... Read more »

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HighCell ChIP kit IPure kit
c-Myc Antagonises the Transcriptional Activity of the Androgen Rece...
Published: April, 2017

Abstract: Prostate cancer (PCa) is the most common non-cutaneous cancer in men. The androgen receptor (AR), a ligand-activated transcription factor, constitu... Read more »

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ChIP-seq Antibody H3K4me3 (C15410003) H3K27ac (C15410174) H3K27me3 (C15410195)
The Rhomboid Protease GlpG Promotes the Persistence of Extraintesti...
Published: April, 2017

Abstract: Extraintestinal pathogenic Escherichia coli (ExPEC) strains are typically benign within the  mammalian gut, but can disperse to extraintestina... Read more »

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Bioruptor
Comparative analysis of MBD-seq and MeDIP-seq and estimation of gen...
Published: March, 2017

Abstract: We conducted a comparative study of multiplexed affinity enrichment sequence methodologies (MBD-seq and MeDIP-seq) in a rodent model of schizophren... Read more »

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MagMeDIP kit MethylCap
The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vit...
Published: March, 2017

Abstract: Background ELF2 (E74-like factor 2) also known as NERF (new Ets-related factor), a member of the Ets family of transcription factors, regulates ... Read more »

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Bioruptor
Epigenetically-driven anatomical diversity of synovial fibroblasts ...
Published: March, 2017

Abstract: A number of human diseases, such as arthritis and atherosclerosis, include characteristic pathology in specific anatomical locations. Here we show ... Read more »

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Antibody Microplex Library Preparation kit
Microinjection of Antibodies Targeting the Lamin A/C Histone-Bindin...
Published: March, 2017

Abstract: Lamins form a scaffold lining the nucleus that binds chromatin and contributes to spatial genome organization; however, due to the many other funct... Read more »

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Antibody
Epigenetically-driven anatomical diversity of synovial fibroblasts ...
Published: March, 2017

Abstract: A number of human diseases, such as arthritis and atherosclerosis, include characteristic pathology in specific anatomical locations. Here we show ... Read more »

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Antibody Microplex Library Preparation kit
JMJD3 aids in reprogramming of bone marrow progenitor cells to hepa...
Published: March, 2017

Abstract: The strictly regulated unidirectional differentiation program in some somatic stem/progenitor cells has been found to be modified in the ectopic si... Read more »

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LowCell ChIP kit
Behavioral, transcriptomic and epigenetic responses to social chall...
Published: March, 2017

Abstract: Understanding how social experiences are represented in the brain and shape future responses is a major challenge in the study of behavior. We addr... Read more »

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ChIP-seq
mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation
Published: March, 2017

Abstract: CD4+ T cells lacking the mTORC1 activator Rheb fail to secrete IFN-γ under Th1 polarizing conditions. We hypothesized that this phenotype is ... Read more »
Trimethylation and Acetylation of β-Catenin at Lysine 49 Represent ...
Published: March, 2017

Abstract: Wnt/β-catenin signaling is required for embryonic stem cell (ESC) pluripotency by inducing mesodermal differentiation and inhibiting neuronal ... Read more »

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Antibody
Chd7 is indispensable for mammalian brain development through activ...
Published: March, 2017

Abstract: Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate that the chromodomain helic... Read more »

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Antibody
Islet-1 induces the differentiation of mesenchymal stem cells into ...
Published: March, 2017

Abstract: Previous studies from this group demonstrated that insulin gene enhancer binding protein ISL-1 (Islet-1) specifically induces the differentiation o... Read more »

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Bioruptor
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of...
Published: March, 2017

Abstract: Methylation of lysine residues on histone tail is a dynamic epigenetic modification that plays a key role in chromatin structure and gene regulatio... Read more »

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Antibody
Decoupling of DNA methylation and activity of intergenic LINE-1 pro...
Published: March, 2017

Abstract: Hypomethylation of LINE-1 repeats in cancer has been proposed as the main mechanism behind their activation; this assumption, however, was based on... Read more »

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Antibody
miR-30a as Potential Therapeutics by Targeting TET1 through Regulat...
Published: March, 2017

Abstract: Several recent studies have indicated that miR-30a plays critical roles in various biological processes and diseases. However, the mechanism of miR... Read more »

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Antibody
Functional variation in allelic methylomes underscores a strong gen...
Published: March, 2017

Abstract: BACKGROUND: The functional impact of genetic variation has been extensively surveyed, revealing that genetic changes correlated to phenotypes li... Read more »

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IP-Star Compact
ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a C...
Published: March, 2017

Abstract: We investigated the relationship among ERK signaling, histone modifications, and transcription factor activity, focusing on the ERK-regulated terna... Read more »

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Antibody
First landscape of binding to chromosomes for a domesticated marine...
Published: March, 2017

Abstract: Setmar is a 3-exons gene coding a SET domain fused to a Hsmar1 transposase. Its different transcripts theoretically encode 8 isoforms with SET moie... Read more »

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Microplex Library Preparation kit
Connexin43 controls N-cadherin transcription during collective cell...
Published: March, 2017

Abstract: Connexins are the primary components of gap junctions, providing direct links between cells in many physiological processes, including cell migrati... Read more »

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Antibody

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    Copenhagen, Denmark
    May 27-May 30, 2017
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