Diagenode

Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

CRISPR-Cas9 Structures and Mechanisms
Published: May, 2017

Abstract: Many bacterial CRISPR-Cas systems employ the dual-RNA-guided DNA endonuclease Cas9 to defend against invading phages and conjugative plasmids by in... Read more »

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Article alert
Conserved effect of aging on DNA methylation and association with E...
Published: February, 2017

Abstract: In humans, DNA methylation at specific CpG sites can be used to estimate the 'epigenetic clock', a biomarker of aging and health. The mechanisms th... Read more »

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MethylCap
Inactivation of Lsd1 triggers senescence in trophoblast stem cells ...
Published: February, 2017

Abstract: Coordination of energy metabolism is essential for homeostasis of stem cells, whereas an imbalance in energy homeostasis causes disease and acceler... Read more »

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IP-Star Compact
An endoparasitoid wasp influences host DNA methylation
Published: February, 2017

Abstract: Parasitism by endoparasitoid wasps changes the expression of various host genes, and alters host immune and developmental processes. However, it is... Read more »
Intestinal NCoR1, a regulator of epithelial cell maturation, contro...
Published: February, 2017

Abstract: Severe neonatal hyperbilirubinemia (SNH) and the onset of bilirubin encephalopathy and kernicterus result in part from delayed expression of UDP-gl... Read more »

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Microplex Library Preparation kit
Overexpression of LINE-1 Retrotransposons in Autism Brain
Published: February, 2017

Abstract: Long interspersed nuclear elements-1 (LINE-1 or L1) are mobile DNA sequences that are capable of duplication and insertion (retrotransposition) wit... Read more »

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MagMeDIP kit
RNF40 regulates gene expression in an epigenetic context-dependent ...
Published: February, 2017

Abstract: BACKGROUND: Monoubiquitination of H2B (H2Bub1) is a largely enigmatic histone modification that has been linked to transcriptional elongation. B... Read more »

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Antibody
Jmjd2c/Kdm4c facilitates the assembly of essential enhancer-protein...
Published: February, 2017

Abstract: Jmjd2 H3K9 demethylases cooperate in promoting mouse embryonic stem cell (ESC) identity. However, little is known about their importance at the exi... Read more »

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Antibody
Epigenetic regulation of RELN and GAD1 in the frontal cortex (FC) o...
Published: February, 2017

Abstract: Both Reelin (RELN) and glutamate decarboxylase 67 (GAD1) have been implicated in the pathophysiology of Autism Spectrum Disorders (ASD). We have pr... Read more »

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Antibody
The non-coding variant rs1800734 enhances DCLK3 expression through ...
Published: February, 2017

Abstract: Genome-wide association studies have identified a great number of non-coding risk variants for colorectal cancer (CRC). To date, the majority of th... Read more »

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Antibody
Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27...
Published: February, 2017

Abstract: Although Men1 is a well-known tumour suppressor gene, little is known about the functions of Menin, the protein it encodes for. Since few years, nu... Read more »

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Antibody
Foxa2, a novel protein partner of tumour suppressor menin, is dereg...
Published: February, 2017

Abstract: Foxa2, known as one of the pioneer factors, plays a crucial role in islet development and endocrine functions. Its expression and biological functi... Read more »
A novel DLX3-PKC integrated signaling network drives keratinocyte d...
Published: February, 2017

Abstract: Epidermal homeostasis relies on a well-defined transcriptional control of keratinocyte proliferation and differentiation, which is critical to prev... Read more »

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Antibody
H3K23me1 is an evolutionarily conserved histone modification associ...
Published: February, 2017

Abstract: Amino-terminal tails of histones are targets for diverse post-translational modifications whose combinatorial action may constitute a code that wil... Read more »

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Antibody IPure kit
Intergenerational Transmission of Enhanced Seizure Susceptibility a...
Published: February, 2017

Abstract: Environmental exposure early in development plays a role in susceptibility to disease in later life. Here, we demonstrate that prolonged febrile se... Read more »

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Antibody
Genome-wide analyses of four major histone modifications in Arabido...
Published: February, 2017

Abstract: Background Hybrid vigour (heterosis) has been used for decades in cropping agriculture, especially in the production of maize and rice, because ... Read more »

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Antibody
Heat Shock Induced Phosphorylation of TAR DNA Binding Protein 43 (T...
Published: February, 2017

Abstract: TAR DNA binding protein (TDP-43) is a highly conserved and essential DNA- and RNA-binding protein that controls gene expression through RNA process... Read more »
Faithful SGCE imprinting in iPSC-derived cortical neurons: an endog...
Published: February, 2017

Abstract: In neuropathology research, induced pluripotent stem cell (iPSC)-derived neurons are considered a tool closely resembling the patient brain. Albeit... Read more »

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Premium Bisulfite Kit
Genomic characterization and dynamic methylation of promoter facili...
Published: February, 2017

Abstract: Differential expression of homomorphous variants of H2A family of histone H2A.1 and H2A.2 have been associated with hepatocellular carcinoma and ma... Read more »

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Antibody
Suppression of RUNX1/ETO oncogenic activity by a small molecule inh...
Published: February, 2017

Abstract: RUNX1/ETO, the product of the t(8;21) chromosomal translocation, is required for the onset and maintenance of one of the most common forms of acute... Read more »

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Antibody
Muscle catabolic capacities and global hepatic epigenome are modifi...
Published: February, 2017

Abstract: Based on the concept of nutritional programming in mammals, we tested whether a short term hyper or hypo vitamin stimulus during first-feeding coul... Read more »

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Antibody
Pharmacological inhibition of DNA methyltransferase 1 promotes neur...
Published: February, 2017

Abstract: Nasal olfactory stem and neural progenitor cells (NOS/PCs) are considered possible tools for regenerative stem cell therapies in neurodegenerative ... Read more »

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Antibody
Differential DNA Methylation Regions in Adult Human Sperm following...
Published: February, 2017

Abstract: BACKGROUND: The potential that adolescent chemotherapy can impact the epigenetic programming of the germ line to influence later life adult fert... Read more »

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Antibody
Chromatin Domain Organization of TCRb locus and its perturbation by...
Published: January, 2017

Abstract: CTCF mediated chromatin interactions influence organization and function of mammalian genome in diverse ways. We analyzed the interactions amongst ... Read more »

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LowCell ChIP kit
DNA methylation heterogeneity defines a disease spectrum in Ewing s...
Published: January, 2017

Abstract: Developmental tumors in children and young adults carry few genetic alterations, yet they have diverse clinical presentation. Focusing on Ewing sar... Read more »

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Antibody
MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer re...
Published: January, 2017

Abstract: In 11q23 leukemias, the N-terminal part of the mixed lineage leukemia (MLL) gene is fused to >60 different partner genes. In order to define a c... Read more »

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Antibody
Snail2 and Zeb2 repress P-Cadherin to define embryonic territories ...
Published: January, 2017

Abstract: Snail and Zeb transcription factors induce epithelial to mesenchymal transition (EMT) in embryonic and adult tissues by direct repression of E-Cadh... Read more »

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Antibody
Epigenetic sampling effects: nephrectomy modifies the clear cell re...
Published: January, 2017

Abstract: Purpose Currently, it is unclear to what extent sampling procedures affect the epigenome. Here, this phenomenon was evaluated by studying the im... Read more »

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MethylCap
Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through deg...
Published: January, 2017

Abstract: Polycomb proteins are critical chromatin modifiers that regulate stem cell differentiation via transcriptional repression. In skeletal muscle proge... Read more »

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Antibody
BMP restricts stemness of intestinal Lgr5(+) stem cells by directly...
Published: January, 2017

Abstract: The intestinal epithelium possesses a remarkable self-renewal ability, which is mediated by actively proliferating Lgr5+ stem cells. Bone morphogen... Read more »

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Microplex Library Preparation kit

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