Diagenode

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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

The histone methyltransferase DOT1L is required for proper DNA dama...
Published: January, 2019

Abstract: BACKGROUND: Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-... Read more »

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Antibody
Global distribution of DNA hydroxymethylation and DNA methylation i...
Published: January, 2019

Abstract: BACKGROUND: Chronic lymphocytic leukemia (CLL) has been a good model system to understand the functional role of 5-methylcytosine (5-mC) in cancer ... Read more »

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MagMeDIP kit Antibody
Optimization of CRISPR/Cas9 Delivery to Human Hematopoietic Stem an...
Published: January, 2019

Abstract: Editing the β-globin locus in hematopoietic stem cells is an alternative therapeutic approach for gene therapy of β-thalassemia and sickl... Read more »

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Antibody
Protocols for Genetic and Epigenetic Studies of Rare Diseases Affec...
Published: January, 2019

Abstract: This chapter describes methods related to the diagnosis of genetic dental diseases. Based on the present knowledge, clinical phenotyping and next-g... Read more »

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MagMeDIP kit IPure kit IP-Star Compact
Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering,...
Published: January, 2019

Abstract: Triple-negative breast cancer (TNBC) cells lack the expression of ER, PR and HER2. Thus, TNBC patients cannot benefit from hormone receptor-targete... Read more »

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iDeal ChIP-seq Kit for Transcription Factors
Gamma radiation induces locus specific changes to histone modificat...
Published: January, 2019

Abstract: Ionizing radiation is a recognized genotoxic agent, however, little is known about the role of the functional form of DNA in these processes. Post ... Read more »

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Antibody
Identification of ChIP-seq and RIME grade antibodies for Estrogen R...
Published: January, 2019

Abstract: Estrogen Receptor alpha (ERα) plays a major role in most breast cancers, and it is the target of endocrine therapies used in the clinic as st... Read more »

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Antibody
Transcriptome-Wide Mapping 5-Methylcytosine by mC RNA Immunoprecipi...
Published: January, 2019

Abstract: Transcriptome-wide mapping RNA modification is crucial to understand the distribution and function of RNA modifications. Here, we describe a protoc... Read more »

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Antibody
Glucocorticoids stimulate hypothalamic dynorphin expression account...
Published: January, 2019

Abstract: Stress-induced reproductive dysfunction is frequently associated with increased glucocorticoid (GC) levels responsible for suppressed GnRH/LH secre... Read more »

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iDeal ChIP-seq Kit for Transcription Factors
Sensitivity of pituitary gonadotropes to hyperglycemia leads to epi...
Published: December, 2018

Abstract: The connection between metabolism and reproductive function is well recognized, and we hypothesized that the pituitary gonadotropes, which produce ... Read more »

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Antibody
DeltaNp63-dependent super enhancers define molecular identity in pa...
Published: December, 2018

Abstract: Molecular subtyping of cancer offers tremendous promise for the optimization of a precision oncology approach to anticancer therapy. Recent advance... Read more »

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Antibody Microplex Library Preparation kit
Reference genome for the WHO reference strain for Mycobacterium bov...
Published: December, 2018

Abstract: Mycobacterium bovis bacillus Calmette-Guérin (M. bovis BCG) is the only vaccine available against tuberculosis (TB). This study reports on a... Read more »

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Megaruptor
Mutant p63 Affects Epidermal Cell Identity through Rewiring the Enh...
Published: December, 2018

Abstract: Transcription factor p63 is a key regulator of epidermal keratinocyte proliferation and differentiation. Mutations in the p63 DNA-binding domain ar... Read more »

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Antibody
The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Re...
Published: December, 2018

Abstract: Zebrafish have a high capacity to replace lost neurons after brain injury. New neurons involved in repair are generated by a specific set of glial ... Read more »

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Microplex Library Preparation kit
Plasmodium falciparum gametocyte-infected erythrocytes do not adher...
Published: December, 2018

Abstract: Plasmodium falciparum gametocytes, the sexual stages responsible for malaria parasite transmission, develop in the human bone marrow parenchyma in ... Read more »

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Antibody
Epigenetic suppression of E-cadherin expression by Snail2 during th...
Published: December, 2018

Abstract: BACKGROUND: The transcription factor Snail2 is a repressor of E-cadherin expression during carcinogenesis; however, the specific mechanisms involve... Read more »

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Antibody
SIRT7-Dependent Deacetylation of Fibrillarin Controls Histone H2A M...
Published: December, 2018

Abstract: Fibrillarin (FBL) is a dual-function nucleolar protein that catalyzes 2'-O methylation of pre-rRNA and methylation of histone H2A at glutamine 104 ... Read more »

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Antibody
Enhancers in the Peril lincRNA locus regulate distant but not local...
Published: December, 2018

Abstract: BACKGROUND: Recently, it has become clear that some promoters function as long-range regulators of gene expression. However, direct and quantitativ... Read more »

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Antibody
The long noncoding RNA and nuclear paraspeckles are up-regulated b...
Published: December, 2018

Abstract: The long noncoding RNA (lncRNA) (nuclear enriched abundant transcript 1) is the architectural component of nuclear paraspeckles, and it has recentl... Read more »

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iDeal ChIP-seq Kit for Transcription Factors
Spatial confinement downsizes the inflammatory response of macropha...
Published: December, 2018

Abstract: Macrophages respond to chemical/metabolic and physical stimuli, but their effects cannot be readily decoupled in vivo during pro-inflammatory activ... Read more »

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True MicroChIP kit
Human retinoic acid-regulated CD161 regulatory T cells support woun...
Published: December, 2018

Abstract: Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we d... Read more »

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Antibody
Can Mitochondrial DNA be CRISPRized: Pro and Contra.
Published: December, 2018

Abstract: Mitochondria represent a chimera of macromolecules encoded either in the organellar genome, mtDNA, or in the nuclear one. If the pathway of protein... Read more »

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Antibody CRISPR Cas9 (C15200203)
Genomic integrity of ground-state pluripotency.
Published: December, 2018

Abstract: Pluripotent cells appear to be in a transient state during early development. These cells have the capability to transition into embryonic stem cel... Read more »

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Antibody
SMRT long reads and Direct Label and Stain optical maps allow the g...
Published: November, 2018

Abstract: Background: The barn swallow (Hirundo rustica) is a migratory bird that has been the focus of a large number of ecological, behavioural and genetic... Read more »

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Megaruptor
Developmental origins of transgenerational sperm DNA methylation ep...
Published: November, 2018

Abstract: Epigenetic alterations in the germline can be triggered by a number of different environmental factors from diet to toxicants. These environmentall... Read more »

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Antibody
Deletion of an intronic HIF-2α binding site suppresses hypoxia-indu...
Published: November, 2018

Abstract: Hypoxia-inducible factors (HIFs) play a key role in the adaptation to low oxygen by interacting with hypoxia response elements (HREs) in the genome... Read more »

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Antibody
Aryl Hydrocarbon Receptor Signaling Cell Intrinsically Inhibits Int...
Published: November, 2018

Abstract: Innate lymphoid cells (ILCs) are important for mucosal immunity. The intestine harbors all ILC subsets, but how these cells are balanced to achieve... Read more »

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iDeal ChIP-seq Kit for Transcription Factors
Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Pr...
Published: November, 2018

Abstract: Inducing graft acceptance without chronic immunosuppression remains an elusive goal in organ transplantation. Using an experimental transplantation... Read more »

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Antibody
Improved reference genome of Aedes aegypti informs arbovirus vector...
Published: November, 2018

Abstract: Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika a... Read more »

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Megaruptor
Sensitive tumour detection and classification using plasma cell-fre...
Published: November, 2018

Abstract: The use of liquid biopsies for cancer detection and management is rapidly gaining prominence. Current methods for the detection of circulating tumo... Read more »

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MagMeDIP kit Antibody IPure kit

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