Diagenode

Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

HDAC1 links early life stress to schizophrenia-like phenotypes
Published: June, 2017

Abstract: Schizophrenia is a devastating disease that arises on the background of genetic predisposition and environmental risk factors, such as early life s... Read more »

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Antibody
ALDH1A3 is epigenetically regulated during melanocyte transformatio...
Published: June, 2017

Abstract: Despite the promising targeted and immune-based interventions in melanoma treatment, long-lasting responses are limited. Melanoma cells present an ... Read more »

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MethylCap
ICF-specific DNMT3B dysfunction interferes with intragenic regulati...
Published: June, 2017

Abstract: Hypomorphic mutations in DNA-methyltransferase DNMT3B cause majority of the rare disorder Immunodeficiency, Centromere instability and Facial anoma... Read more »

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Antibody
Transcription Factor Interplay between LEAFY and APETALA1/CAULIFLOW...
Published: June, 2017

Abstract: The transcription factors LEAFY (LFY) and APETALA1 (AP1), together with the AP1 paralog CAULIFLOWER (CAL), control the onset of flower development ... Read more »
A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognit...
Published: June, 2017

Abstract: The balance between detrimental, pro-aging, often stochastic processes and counteracting homeostatic mechanisms largely determines the progression ... Read more »

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LowCell ChIP kit
CRISPR-Cas9 Structures and Mechanisms
Published: May, 2017

Abstract: Many bacterial CRISPR-Cas systems employ the dual-RNA-guided DNA endonuclease Cas9 to defend against invading phages and conjugative plasmids by in... Read more »

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Article alert
MeDIP-seq and nCpG analyses illuminate sexually dimorphic methylati...
Published: May, 2017

Abstract: Background DNA methylation alters gene expression but not DNA sequence and mediates some cases of phenotypic plasticity. Temperature-dependent s... Read more »

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MagMeDIP kit
ASXL2 is essential for haematopoiesis and acts as a haploinsufficie...
Published: May, 2017

Abstract: Additional sex combs-like (ASXL) proteins are mammalian homologues of additional sex combs (Asx), a regulator of trithorax and polycomb function in... Read more »

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IP-Star Compact
Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription f...
Published: May, 2017

Abstract: Monomethylation of histone H3 at lysine 4 (H3K4me1) and acetylation of histone H3 at lysine 27 (H3K27ac) are correlated with transcriptionally enga... Read more »

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Antibody
Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcr...
Published: May, 2017

Abstract: Monocytes are circulating, short-lived mononuclear phagocytes, which in mice and man comprise two main subpopulations. MurineLy6C+ monocytes displa... Read more »

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Bioruptor
Evolutionary re-wiring of p63 and the epigenomic regulatory landsca...
Published: May, 2017

Abstract: Although epidermal keratinocyte development and differentiation proceeds in similar fashion between humans and mice, evolutionary pressures have al... Read more »

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Antibody IP-Star Compact
RNA Polymerase III Subunit POLR3G Regulates Specific Subsets of Pol...
Published: May, 2017

Abstract: POLR3G is expressed at high levels in human pluripotent stem cells (hPSCs) and is required for maintenance of stem cell state through mechanisms no... Read more »

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Antibody Microplex Library Preparation kit
The adaptor protein ARA55 and the nuclear kinase HIPK1 assist c-Myb...
Published: May, 2017

Abstract: LIM-domain proteins, containing multiple cysteine-rich zinc finger-like motifs, have been shown to play diverse roles in several cellular processes... Read more »

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Bioruptor
TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cy...
Published: May, 2017

Abstract: Aberrant WNT signaling drives colorectal cancer (CRC). Here, we identify TIAM1 as a critical antagonist of CRC progression through inhibiting TAZ a... Read more »

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Microplex Library Preparation kit
CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenet...
Published: May, 2017

Abstract: An oncogenic role for CHD4, a NuRD component, is defined for initiating and supporting tumor suppressor gene (TSG) silencing in human colorectal ca... Read more »

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Antibody
LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learni...
Published: May, 2017

Abstract: One of the exceptional properties of the brain is its ability to acquire new knowledge through learning and to store that information through memor... Read more »

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IPure kit
The Dynamic Epigenetic Landscape of the Retina During Development, ...
Published: May, 2017

Abstract: In the developing retina, multipotent neural progenitors undergo unidirectional differentiation in a precise spatiotemporal order. Here we profile ... Read more »

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ChIP-seq Antibody
PPARγ Links BMP2 and TGFβ1 Pathways in Vascular Smooth Muscle Cells...
Published: May, 2017

Abstract: BMP2 and TGFβ1 are functional antagonists of pathological remodeling in the arteries, heart, and lung; however, the mechanisms in VSMCs, and t... Read more »

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ChIP-seq IPure kit
Mercury-induced epigenetic transgenerational inheritance of abnorma...
Published: May, 2017

Abstract: Methylmercury (MeHg) is a ubiquitous environmental neurotoxicant, with human exposures predominantly resulting from fish consumption. Developmental... Read more »

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Antibody
sgs1: a neomorphic nac52 allele impairing PTGS through SGS3 down-re...
Published: May, 2017

Abstract: Post-transcriptional gene silencing (PTGS) is a defense mechanism that targets invading nucleic acids from endogenous (transposons) or exogenous (p... Read more »

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IPure kit
Protective vaccination and blood-stage malaria modify DNA methylati...
Published: May, 2017

Abstract: Epigenetic mechanisms such as DNA methylation are increasingly recognized to be critical for vaccination efficacy and outcome of different infectio... Read more »

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MagMeDIP kit
Novel Molecular Mechanism of Regulation of CD40 Ligand by the Trans...
Published: April, 2017

Abstract: The interaction between tumor cells and their surrounding microenvironment is essential for the growth and persistence of cancer cells. This intera... Read more »

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Bioruptor
Egr2 and 3 Inhibit T-bet–Mediated IFN-γ Production in T Cells
Published: April, 2017

Abstract: T-bet is important for differentiation of cytotoxic CD8 and Th1 CD4 T cells. We have discovered that Egr2 and 3 are potent inhibitors of T-bet func... Read more »
Critical threshold levels of DNA methyltransferase 1 are required t...
Published: April, 2017

Abstract: Reversing DNA methylation abnormalities and associated gene silencing, through inhibiting DNA methyltransferases (DNMTs) is an important potential ... Read more »

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Antibody
Characterization of the Polycomb-Group Mark H3K27me3 in Unicellular...
Published: April, 2017

Abstract: Polycomb Group (PcG) proteins mediate chromatin repression in plants and animals by catalyzing H3K27 methylation and H2AK118/119 mono-ubiquitinatio... Read more »

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Antibody Microplex Library Preparation kit
DNA breaks and chromatin structural changes enhance the transcripti...
Published: April, 2017

Abstract: The autoimmune regulator (AIRE) protein is the key factor in thymic negative selection of autoreactive T cells by promoting the ectopic expression ... Read more »

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Antibody IP-Star Compact
The Role of S-Palmitoylation of the Human Glucocorticoid Receptor (...
Published: April, 2017

Abstract: Background: Many rapid nongenomic glucocorticoid actions are mediated by membrane-bound glucocorticoid receptors (GRs). S-palmitoylation is a lipid... Read more »

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Antibody
Liver receptor homolog-1 (NR5a2) regulates CD95/Fas ligand transcri...
Published: April, 2017

Abstract: CD95/Fas ligand (FasL) is a cell death-promoting member of the tumor necrosis factor family with important functions in the regulation of T-cell ho... Read more »

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IPure kit
Genomic responses of mouse synovial fibroblasts during TNF-driven a...
Published: April, 2017

Abstract: OBJECTIVE: Aberrant activation of synovial fibroblasts (SFs) is a key determinant in the pathogenesis of rheumatoid arthritis (RA). We aimed to pr... Read more »

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Bioruptor ChIP-seq Antibody
Comparative Analysis of Ralstonia solanacearum Methylomes
Published: April, 2017

Abstract: Ralstonia solanacearum is an important soil-borne plant pathogen with broad geographical distribution and the ability to cause wilt disease in many... Read more »

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Megaruptor

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