Genome-wide rules of nucleosome phasing Published: June, 2018 Abstract:
Regular successions of positioned nucleosomes – phased nucleosome arrays (PNAs) – are predominantly known from transcriptional start sites (TSS). It is unclear whether PNAs occur elsewhere in the genome. To generate a comprehensive inv... Read more »
Genome-wide analysis of PDX1 target genes in human pancreatic progenitors. Published: March, 2018 Abstract:
OBJECTIVE: Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor (TF) PDX1 leads to pancreatic agenesis, whereas heterozygous mutations can cause Maturity-Onset Diabetes of the Young 4 (MODY4). Although the... Read more »
MLL2 conveys transcription-independent H3K4 trimethylation in oocytes Published: January, 2018 Abstract:
Histone 3 K4 trimethylation (depositing H3K4me3 marks) is typically associated with active promoters yet paradoxically occurs at untranscribed domains. Research to delineate the mechanisms of targeting H3K4 methyltransferases is ongoing. The oocyt... Read more »
Epigenome profiling and editing of neocortical progenitor cells during development Published: September, 2017 Abstract:
The generation of neocortical neurons from neural progenitor cells (NPCs) is primarily controlled by transcription factors binding to DNA in the context of chromatin. To understand the complex layer of regulation that orchestrates different NPC ty... Read more »
Characterization of the Polycomb-Group Mark H3K27me3 in Unicellular Algae Published: April, 2017 Abstract:
Polycomb Group (PcG) proteins mediate chromatin repression in plants and animals by catalyzing H3K27 methylation and H2AK118/119 mono-ubiquitination through the activity of the Polycomb repressive complex 2 (PRC2) and PRC1, respectively. PcG prote... Read more »
Crebbp loss cooperates with Bcl2 over-expression to promote lymphoma in mice Published: March, 2017 Abstract:
CREBBP is targeted by inactivating mutations in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). Here, we provide evidence from transgenic mouse models that Crebbp deletion results in deficits in B-cell development and can coope... Read more »
The Drosophila speciation factor HMR localizes to genomic insulator sites Published: February, 2017 Abstract:
Hybrid incompatibility between Drosophila melanogaster and D. simulans is caused by a lethal interaction of the proteins encoded by the Hmr and Lhr genes. In D. melanogaster the loss of HMR results in mitotic defects, an increase in transcription ... Read more »
PionX sites mark the X chromosome for dosage compensation Published: August, 2016 Abstract:
The rules defining which small fraction of related DNA sequences can be selectively bound by a transcription factor are poorly understood. One of the most challenging tasks in DNA recognition is posed by dosage compensation systems that require th... Read more »
Sepsis induces specific changes in histone modification patterns in human monocytes. Published: March, 2015 Abstract:
BACKGROUND: Sepsis is a global burden and the primary cause of death in intensive care units worldwide. The pathophysiological changes induced by the host's systemic inflammatory response to infection are not yet fully understood. During sepsis, t... Read more »
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