Shearing Technologies

Diagenode focuses on state-of-the-art preparation of high quality biological samples and is dedicated to the most advanced analytical methods. Achieving proper fragment sizes for input DNA, chromatin, or RNA is crucial for various techniques, and Diagenode has developed the most advanced water bath sonicators (the Bioruptor® for 150bp - 2kb), a unique desktop sonication device (the One® for 150bp - 1kb) and a unique hydrodynamic shearing instrument (the Megaruptor® for 2kb - 75kb) to cover a range of applications. The Bioruptor® is available in two models: the Bioruptor® Plus, specifically designed for ChIP-PCR and other applications, and the Bioruptor® Pico for ChIP-seq and NGS. The Megaruptor® is the best shearing device for the tightest distribution of long DNA fragments. The One® is the new desktop solution that provides optimal small volume DNA shearing for Next-Generation-Sequencing.





  • All in one shearing device
  • Advanced temperature control
  • > 2000 peer reviewed publications
  • Optimal for long DNA fragment generation
  • Tight fragment length distribution
  • Hydropores eliminate clogging issue
  • Compact size
  • Small volume DNA and Chromatin shearing
  • Fully integrated system


  • DNA, Chromatin and RNA shearing 150bp to 2kb
  • FFPE DNA and RNA extraction
  • Protein extraction from cells and tissues
  • Chemical applications (liposomes, emulsifications etc.)
  • DNA shearing 2kb to 75kb
  • DNA and Chromatin shearing 150bp to 1kb

Diagenode has partnered with leading innovative companies to optimize workflows through the greater incorporation of Bioruptor® technology.

Learn more


  • Bioruptor-pico-next-gen-sequencing
    Bioruptor® Pico sonication device
  • some alt
    Bioruptor® Plus sonication device


  • Megaruptor 2
    Megaruptor® 2


  • Bioruptor One
    Diagenode One sonication device


  • Epigenetic Mechanisms in Health and Disease 2017
    Barcelona, Spain
    Oct 25-Oct 26, 2017
  • 35ème Congrès de la Societé Française de Toxicologie Génétique
    Marseille, France
    Oct 26-Oct 27, 2017
  • 7th Australian Epigenetics Conference
    Brisbane, Australia
    Oct 29-Nov 1, 2017
  • Australian Genomic Technologies Association (AGTA 2017 Annual Conference)
    Hobart, Tasmania
    Oct 29-Nov 1, 2017
 See all events

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