Diagenode

Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Life-Long AAV-Mediated CRISPR Genome Editing in Dystrophic Heart Im...
Published: May, 2019

Abstract: Previous studies from others and us have demonstrated that CRISPR genome editing could offer a promising therapeutic strategy to restore dystrophin... Read more »

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Antibody
Acetate Promotes T Cell Effector Function during Glucose Restriction.
Published: May, 2019

Abstract: Competition for nutrients like glucose can metabolically restrict T cells and contribute to their hyporesponsiveness during cancer. Metabolic ... Read more »

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Antibody
Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeut...
Published: May, 2019

Abstract: High-grade gliomas defined by histone 3 K27M driver mutations exhibit global loss of H3K27 trimethylation and reciprocal gain of H3K27 acetylation,... Read more »

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Antibody IP-Star Compact iDeal ChIP-seq Kit for Histones
BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Re...
Published: May, 2019

Abstract: Drug-tolerant "persister" tumor cells underlie emergence of drug-resistant clones and contribute to relapse and disease progression. Here we report... Read more »

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Antibody
The methylation pattern of DNA and complex correlations with gene e...
Published: May, 2019

Abstract: Chinese cabbage (Brassica rapa L. ssp. pekinensis) is one of the most important economic crops. However, its yield and quality can be severely thre... Read more »

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MagMeDIP kit
Genome Sequence and Methylation Patterns of sp. Strain BOL3-1, the...
Published: May, 2019

Abstract: sp. strain BOL3-1 was isolated from Salar de Uyuni, Bolivia, and sequenced using single-molecule real-time sequencing. Its 3.7-Mbp genome was analy... Read more »

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Megaruptor
Epigenetic Alterations in Juvenile Spondyloarthritis Patients: a Pr...
Published: May, 2019

Abstract: Juvenile spondyloarthritis (jSpA) is a complex disease with both genetic and environmental factors contributing to etiology. Multiple studies have ... Read more »

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MagMeDIP kit
Cardiac Reprogramming Factors Synergistically Activate Genome-wide ...
Published: May, 2019

Abstract: The cardiogenic transcription factors (TFs) Mef2c, Gata4, and Tbx5 can directly reprogram fibroblasts to induced cardiac-like myocytes (iCLMs), pre... Read more »

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Antibody
Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory i...
Published: May, 2019

Abstract: BACKGROUND: Rewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing... Read more »

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Antibody
Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Tra...
Published: May, 2019

Abstract: The gene regulatory network (GRN) of naive mouse embryonic stem cells (ESCs) must be reconfigured to enable lineage commitment. TCF3 sanctions rewi... Read more »

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Antibody
Guidelines for optimized gene knockout using CRISPR/Cas9
Published: May, 2019

Abstract: CRISPR/Cas9 technology has evolved as the most powerful approach to generate genetic models both for fundamental and preclinical research. Despite ... Read more »

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IP-Star Compact Microplex Library Preparation kit iDeal ChIP-seq Kit for Transcription Factors CRISPR
Interferon signature in patients with STAT1 gain-of-function mutati...
Published: May, 2019

Abstract: STAT1 gain-of-function (GOF) variants lead to defective Th17 cell development and chronic mucocutaneous candidiasis (CMC), but frequently also... Read more »

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IP-Star Compact
The Chromatin Factor HNI9 and ELONGATED HYPOCOTYL5 Maintain ROS Hom...
Published: May, 2019

Abstract: Reactive oxygen species (ROS) can accumulate in cells at excessive levels, leading to unbalanced redox states and to potential oxidative stress, wh... Read more »

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Antibody
Repression of Germline Genes in Somatic Tissues by H3K9 Dimethylat...
Published: May, 2019

Abstract: Repression of germline-promoting genes in somatic cells is critical for somatic development and function. To study how germline genes are repressed... Read more »

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IP-Star Compact
Long-range interactions between topologically associating domains s...
Published: May, 2019

Abstract: Genomic information is selectively used to direct spatial and temporal gene expression during differentiation. Interactions between topologically a... Read more »

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Antibody
Epigenetic control of the angiotensin-converting enzyme in endothel...
Published: May, 2019

Abstract: The angiotensin-converting enzyme (ACE) plays a central role in the renin-angiotensin system, which is involved in the regulation of blood pressure... Read more »

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MagMeDIP kit
Epigenetic modulation of a hardwired 3D chromatin landscape in two ...
Published: May, 2019

Abstract: The mechanisms underlying enhancer activation and the extent to which enhancer-promoter rewiring contributes to spatiotemporal gene expression are ... Read more »

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Antibody
Bromodomain inhibition of the coactivators CBP/EP300 facilitate cel...
Published: May, 2019

Abstract: Silencing of the somatic cell type-specific genes is a critical yet poorly understood step in reprogramming. To uncover pathways that maintain cell... Read more »

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Antibody
Canonical PRC1 controls sequence-independent propagation of Polycom...
Published: April, 2019

Abstract: Polycomb group (PcG) proteins play critical roles in the epigenetic inheritance of cell fate. The Polycomb Repressive Complexes PRC1 and PRC2 catal... Read more »

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Antibody
Genome-wide DNA methylation profiles in Tibetan and Yorkshire pigs ...
Published: April, 2019

Abstract: Background: Tibetan pigs, which inhabit the Tibetan Plateau, exhibit distinct phenotypic and physiological characteristics from those of lowland pi... Read more »

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MagMeDIP kit
P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Res...
Published: April, 2019

Abstract: DNA damage response (DDR) involves dramatic transcriptional alterations, the mechanisms of which remain ill defined. Here, we show that following g... Read more »

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Bioruptor
BRCA1 mutations attenuate super-enhancer function and chromatin loo...
Published: April, 2019

Abstract: BACKGROUND: BRCA1-associated breast cancer originates from luminal progenitor cells. BRCA1 functions in multiple biological processes, including do... Read more »

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Microplex Library Preparation kit
PML modulates H3.3 targeting to telomeric and centromeric repeats i...
Published: April, 2019

Abstract: Targeted deposition of histone variant H3.3 into chromatin is paramount for proper regulation of chromatin integrity, particularly in heterochromat... Read more »

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Antibody
Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecul...
Published: April, 2019

Abstract: Studies in vertebrates have outlined conserved molecular control of definitive endoderm (END) development. However, recent work also shows that key... Read more »

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Antibody
The Reference Genome Sequence of Scutellaria baicalensis Provides I...
Published: April, 2019

Abstract: Scutellaria baicalensis Georgi is important in Chinese traditional medicine where preparations of dried roots, "Huang Qin," are used for liver and ... Read more »

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Megaruptor
Long intergenic non-coding RNAs regulate human lung fibroblast func...
Published: April, 2019

Abstract: Phenotypic changes in lung fibroblasts are believed to contribute to the development of Idiopathic Pulmonary Fibrosis (IPF), a progressive and fata... Read more »

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Antibody iDeal ChIP-seq Kit for Histones
Defining UHRF1 Domains that Support Maintenance of Human Colon Canc...
Published: April, 2019

Abstract: UHRF1 facilitates the establishment and maintenance of DNA methylation patterns in mammalian cells. The establishment domains are defined, includin... Read more »

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Antibody
TET3 prevents terminal differentiation of adult NSCs by a non-catal...
Published: April, 2019

Abstract: Ten-eleven-translocation (TET) proteins catalyze DNA hydroxylation, playing an important role in demethylation of DNA in mammals. Remarkably, altho... Read more »

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Antibody
Dissecting the role of H3K27 acetylation and methylation in PRC2 me...
Published: April, 2019

Abstract: The Polycomb repressive complexes PRC1 and PRC2 act non-redundantly at target genes to maintain transcriptional programs and ensure cellular identi... Read more »

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Antibody
Essential Gene Profiles for Human Pluripotent Stem Cells Identify U...
Published: April, 2019

Abstract: Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding... Read more »

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Antibody

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