Diagenode

Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediat...
Published: September, 2019

Abstract: Acute myeloid leukemia (AML) is associated with mutations in transcriptional and epigenetic regulator genes impairing myeloid differentiation. The ... Read more »

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Antibody
Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acety...
Published: September, 2019

Abstract: Inactivating mutations of the CREBBP and EP300 acetyltransferases are among the most common genetic alterations in diffuse large B cell lymphoma (D... Read more »

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Antibody
Functional analyses of a low-penetrance risk variant rs6702619/1p21...
Published: September, 2019

Abstract: Several studies employed the genome-wide association (GWA) analysis of single-nucleotide polymorphisms (SNPs) to identify susceptibility regions in... Read more »

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Antibody
Relationship between osteoporosis and osteoarthritis based on DNA m...
Published: September, 2019

Abstract: : The aim of this study was to investigate the relationship between osteoporosis and osteoarthritis by analyzing the DNA methylation in osteoporosi... Read more »

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Antibody
Improved double-nicking strategies for COL7A1 editing by homologous...
Published: September, 2019

Abstract: Current gene editing approaches for treatment of recessive dystrophic epidermolysis bullosa (RDEB), an inherited, severe form of blistering skin di... Read more »

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Antibody
Improved Double-Nicking Strategies for COL7A1-Editing by Homologous...
Published: September, 2019

Abstract: Current gene-editing approaches for treatment of recessive dystrophic epidermolysis bullosa (RDEB), an inherited, severe form of blistering skin di... Read more »

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Antibody
Cooperation of cancer drivers with regulatory germline variants sha...
Published: September, 2019

Abstract: Pediatric malignancies including Ewing sarcoma (EwS) feature a paucity of somatic alterations except for pathognomonic driver-mutations that cannot... Read more »

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iDeal ChIP-seq Kit for Transcription Factors
Residual apoptotic activity of a tumorigenic p53 mutant improves ca...
Published: September, 2019

Abstract: Engineered p53 mutant mice are valuable tools for delineating p53 functions in tumor suppression and cancer therapy. Here, we have introduced the R... Read more »

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Microplex Library Preparation kit
β-Glucan-Induced Trained Immunity Protects against Leishmania brazi...
Published: September, 2019

Abstract: American tegumentary leishmaniasis is a vector-borne parasitic disease caused by Leishmania protozoans. Innate immune cells undergo long-term funct... Read more »

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Antibody
Reactivation of super-enhancers by KLF4 in human Head and Neck Squa...
Published: September, 2019

Abstract: Head and neck squamous cell carcinoma (HNSCC) is a disease of significant morbidity and mortality and rarely diagnosed in early stages. Despite ext... Read more »

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Antibody IP-Star Compact
The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic...
Published: September, 2019

Abstract: Enzymes that catalyse CpG methylation in DNA, including the DNA methyltransferases 1 (DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for ma... Read more »

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IP-Star Compact iDeal ChIP-seq Kit for Histones
Preparation of cfMeDIP-seq libraries for methylome profiling of pla...
Published: August, 2019

Abstract: Circulating cell-free DNA (cfDNA) comprises small DNA fragments derived from normal and tumor tissue that are released into the bloodstream. Recent... Read more »

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MagMeDIP kit Antibody IPure kit
BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-n...
Published: August, 2019

Abstract: Therapeutic strategies aiming to leverage anti-tumor immunity are being intensively investigated as they show promising results in cancer therapy. ... Read more »

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Antibody
Human mitochondrial DNA is extensively methylated in a non-CpG context
Published: August, 2019

Abstract: Mitochondrial dysfunction plays critical roles in cancer development and related therapeutic response; however, exact molecular mechanisms remain u... Read more »

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MagMeDIP kit IP-Star Compact
Long-read sequencing and haplotype linkage analysis enabled preimpl...
Published: August, 2019

Abstract: BACKGROUND: Preimplantation genetic testing (PGT) has already been applied in patients known to carry chromosomal structural variants to improve th... Read more »

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Megaruptor
Nucleome Dynamics during Retinal Development.
Published: August, 2019

Abstract: More than 8,000 genes are turned on or off as progenitor cells produce the 7 classes of retinal cell types during development. Thousands of enhance... Read more »

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Antibody iDeal ChIP-seq Kit for Histones
Silencing of tumor-suppressive NR_023387 in renal cell carcinoma vi...
Published: August, 2019

Abstract: Dysregulation of the epigenetic status of long noncoding RNAs (lncRNAs) has been linked to diverse human diseases including human cancers. However,... Read more »

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Antibody
Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macropha...
Published: August, 2019

Abstract: Macrophage polarization is accompanied by drastic changes in L-arginine metabolism. Two L-arginine catalytic enzymes, iNOS and arginase 1, are well... Read more »

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Antibody
Single-base methylome profiling of the giant kelp Saccharina japoni...
Published: August, 2019

Abstract: Brown algae have convergently evolved plant-like body plans and reproductive cycles, which in plants are controlled by differential DNA methylation... Read more »

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MagMeDIP kit
Novel Interactions between the Human T-Cell Leukemia Virus Type 1 A...
Published: August, 2019

Abstract: The human T-cell leukemia virus type 1 (HTLV-1) regulatory proteins Tax and HBZ play indispensable roles in regulating viral and cellular gene expr... Read more »

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HighCell ChIP kit
The nuclear hypoxia-regulated NLUCAT1 long non-coding RNA contribut...
Published: August, 2019

Abstract: Lung cancer is the leading cause of cancer death worldwide, with poor prognosis and a high rate of recurrence despite early surgical removal. Hypox... Read more »

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iDeal ChIP-qPCR ChIP Cross-link Gold
Epitranscriptomic Addition of mC to HIV-1 Transcripts Regulates Vir...
Published: August, 2019

Abstract: How the covalent modification of mRNA ribonucleotides, termed epitranscriptomic modifications, alters mRNA function remains unclear. One issue... Read more »

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Antibody
Human cardiac fibrosis-on-a-chip model recapitulates disease hallma...
Published: August, 2019

Abstract: While interstitial fibrosis plays a significant role in heart failure, our understanding of disease progression in humans is limited. To address th... Read more »

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CATS
Accurate circular consensus long-read sequencing improves variant d...
Published: August, 2019

Abstract: The DNA sequencing technologies in use today produce either highly accurate short reads or less-accurate long reads. We report the optimization of ... Read more »

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Megaruptor
Free heme regulates placenta growth factor through NRF2-antioxidant...
Published: August, 2019

Abstract: Free heme activates erythroblasts to express and secrete Placenta Growth Factor (PlGF), an angiogenic peptide of the VEGF family. High circulating ... Read more »

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Antibody
EZH2 as a novel therapeutic target for atrial fibrosis and atrial f...
Published: August, 2019

Abstract: Angiotensin II (Ang-II)-induced fibroblast differentiation plays an important role in the development of atrial fibrosis and atrial fibrillation (A... Read more »

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HighCell ChIP kit IPure kit
Transit amplifying cells coordinate mouse incisor mesenchymal stem ...
Published: August, 2019

Abstract: Stem cells (SCs) receive inductive cues from the surrounding microenvironment and cells. Limited molecular evidence has connected tissue-specific m... Read more »

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Antibody
Clinicopathological evaluation of PD-L1 expression and cytotoxic T-...
Published: August, 2019

Abstract: Immune check-point blockade (ICB) targeting programmed cell death ligand-1 (PD-L1)/programmed death-1 (PD-1) axis has created paradigm shift in can... Read more »

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IPure kit
Proteomics Links Ubiquitin Chain Topology Change to Transcription F...
Published: August, 2019

Abstract: A surprising complexity of ubiquitin signaling has emerged with identification of different ubiquitin chain topologies. However, mechanisms of how ... Read more »

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Bioruptor
Interaction of Sox2 with RNA binding proteins in mouse embryonic st...
Published: August, 2019

Abstract: Sox2 is a master transcriptional regulator of embryonic development. In this study, we determined the protein interactome of Sox2 in the chromatin ... Read more »

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True MicroChIP kit Beads

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