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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Discovery of a new predominant cytosine DNA modification that is li...
Published: November, 2019

Abstract: DNA cytosine modifications are key epigenetic regulators of cellular processes in mammalian cells, with their misregulation leading to varied disea... Read more »

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Microplex Library Preparation kit
A stress-responsive enhancer induces dynamic drug resistance in acu...
Published: November, 2019

Abstract: The drug efflux pump ABCB1 is a key driver of chemoresistance, and high expression predicts for treatment failure in acute myeloid leukemia (AML). ... Read more »

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Microplex Library Preparation kit
DAPK1 loss triggers tumor invasion in colorectal tumor cells.
Published: November, 2019

Abstract: Colorectal cancer (CRC) is one of the leading cancer-related causes of death worldwide. Despite the improvement of surgical and chemotherapeutic tr... Read more »

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CRISPR
Detection of Abrin-Like and Prepropulchellin-Like Toxin Genes and T...
Published: November, 2019

Abstract: The sequenced genome and the leaf transcriptome of a near relative of and was analyzed to characterize the genetic basis of toxin gene expression. ... Read more »

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Megaruptor
MicroRNA-708 is a novel regulator of the Hoxa9 program in myeloid c...
Published: November, 2019

Abstract: MicroRNAs (miRNAs) are commonly deregulated in acute myeloid leukemia (AML), affecting critical genes not only through direct targeting, but also t... Read more »

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Antibody
Intra- and inter-generational changes in the cortical DNA methylome...
Published: November, 2019

Abstract: Recent evidence from our lab documents functional resilience to retinal ischemic injury in untreated mice derived from parents exposed to repetitiv... Read more »

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Antibody
R-Loops Promote Antisense Transcription across the Mammalian Genome
Published: November, 2019

Abstract: Widespread antisense long noncoding RNA (lncRNA) overlap with many protein-coding genes in mammals and emanate from gene promoter, enhancer, and te... Read more »

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Antibody
Autoregulation of RCO by Low-Affinity Binding Modulates Cytokinin A...
Published: November, 2019

Abstract: Mechanisms through which the evolution of gene regulation causes morphological diversity are largely unclear. The tremendous shape variation among ... Read more »

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Antibody
CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Andr...
Published: November, 2019

Abstract: Androgen-receptor (AR) inhibitors, including enzalutamide, are used for treatment of all metastatic castration-resistant prostate cancers (mCRPCs).... Read more »

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Antibody
Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Intera...
Published: November, 2019

Abstract: Mammalian switch/sucrose non-fermentable (mSWI/SNF) complexes are multi-component machines that remodel chromatin architecture. Dissection of the s... Read more »

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Antibody
Plasticity of histone modifications around Cidea and Cidec genes wi...
Published: November, 2019

Abstract: We recently reported that a treatment with tauroursodeoxycholic acid (TUDCA), a secondary bile acid, improved developmentally-deteriorated hepatic ... Read more »

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MethylCap
MicroRNAs Establish the Right-Handed Dominance of the Heart Lateral...
Published: November, 2019

Abstract: Despite their external bilateral symmetry, vertebrates have internal left/right (L/R) asymmetries required for optimal organ function. BMP-induced ... Read more »

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Antibody
NanoSatellite: accurate characterization of expanded tandem repeat ...
Published: November, 2019

Abstract: Technological limitations have hindered the large-scale genetic investigation of tandem repeats in disease. We show that long-read sequencing with ... Read more »

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Megaruptor
Lithium treatment reverses irradiation-induced changes in rodent ne...
Published: November, 2019

Abstract: Cranial radiotherapy in children has detrimental effects on cognition, mood, and social competence in young cancer survivors. Treatments harnessing... Read more »

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MagMeDIP kit Antibody
Sperm DNA Methylation Epimutation Biomarkers for Male Infertility a...
Published: November, 2019

Abstract: Male factor infertility is increasing and recognized as playing a key role in reproductive health and disease. The current primary diagnostic appro... Read more »

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Antibody
Distinct CoREST complexes act in a cell-type-specific manner.
Published: November, 2019

Abstract: CoREST has been identified as a subunit of several protein complexes that generate transcriptionally repressive chromatin structures during develop... Read more »

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Microplex Library Preparation kit
Identification and Massively Parallel Characterization of Regulator...
Published: November, 2019

Abstract: Epigenomic regulation and lineage-specific gene expression act in concert to drive cellular differentiation, but the temporal interplay between the... Read more »

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LowCell ChIP kit IPure kit
Distinct IL-1α-responsive enhancers promote acute and coordinated c...
Published: November, 2019

Abstract: How cytokine-driven changes in chromatin topology are converted into gene regulatory circuits during inflammation still remains unclear. Here, we s... Read more »

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Antibody
Native Chromatin Proteomics Reveals a Role for Specific Nucleoporin...
Published: November, 2019

Abstract: Spatially and functionally distinct domains of heterochromatin and euchromatin play important roles in the maintenance of chromosome stability and ... Read more »

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Antibody
Epigenetic remodelling licences adult cholangiocytes for organoid f...
Published: November, 2019

Abstract: Following severe or chronic liver injury, adult ductal cells (cholangiocytes) contribute to regeneration by restoring both hepatocytes and cholangi... Read more »

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Antibody LowCell ChIP kit IPure kit
Epigenetic transgenerational inheritance of parent-of-origin alleli...
Published: October, 2019

Abstract: Epigenetic transgenerational inheritance potentially impacts disease etiology, phenotypic variation, and evolution. An increasing number of environ... Read more »

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Antibody
The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Est...
Published: October, 2019

Abstract: Notwithstanding the positive clinical impact of endocrine therapies in estrogen receptor-alpha (ERα)-positive breast cancer, de novo and acqu... Read more »

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Antibody
Circulating miRNA analysis for cancer diagnostics and therapy.
Published: October, 2019

Abstract: Successful treatment of cancer depends on early diagnosis and effective monitoring of patients' response to therapy. Traditional tools based on tum... Read more »

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CATS
Obesogen effect of bisphenol S alters mRNA expression and DNA methy...
Published: October, 2019

Abstract: Environmental pollution is increasingly considered an important factor involved in the obesity incidence. Endocrine disruptors (EDs) are important ... Read more »

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Premium RRBS Kit DNA Methylation Profiling (RRBS Service)
TET2 Regulates the Neuroinflammatory Response in Microglia.
Published: October, 2019

Abstract: Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for microglia in neuroinflam... Read more »

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Antibody
Epigenetic down-regulation of the HIST1 locus predicts better progn...
Published: October, 2019

Abstract: BACKGROUND: The epigenetic machinery is frequently altered in acute myeloid leukemia. Focusing on cytogenetically normal (CN) AML, we previously de... Read more »

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IPure kit
Physical and functional interaction between SET1/COMPASS complex co...
Published: October, 2019

Abstract: The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated CpG rich promoters to implement tri-methylation of histone H3 ... Read more »

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Antibody
17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breas...
Published: October, 2019

Abstract: Heat Shock Factor 1 (HSF1) is a key regulator of gene expression during acute environmental stress that enables the cell survival, which is also in... Read more »

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iDeal ChIP-seq Kit for Transcription Factors
CURLY LEAF regulates micro RNA activity by controlling ARGONAUTE 1 ...
Published: October, 2019

Abstract: CURLY LEAF (CLF) encodes the methyl-transferase sub-unit of the Polycomb Repressor Complex 2 (PRC2), which regulates the expression of target genes... Read more »

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Antibody
Genomic and phenotypic analyses of six offspring of a genome-edited...
Published: October, 2019

Abstract: Genome editing followed by reproductive cloning was previously used to produce two hornless dairy bulls. We crossed one genome-edited dairy bull, h... Read more »

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Megaruptor

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