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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Integrative Analysis of Glucometabolic Traits, Adipose Tissue DNA M...
Published: September, 2020

Abstract: Decline in insulin sensitivity due to dysfunction of adipose tissue (AT) is one of the earliest pathogenic events in Type 2 Diabetes. We hypothesiz... Read more »

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Premium RRBS Kit DNA Methylation Profiling (RRBS Service)
Genes with 5′ terminal oligopyrimidine tracts preferentially escape...
Published: September, 2020

Abstract: Viruses rely on the host translation machinery to synthesize their own proteins. Consequently, they have evolved varied mechanisms to co-opt host t... Read more »
Epigenetic effects of low-level sodium arsenite exposure on human l...
Published: August, 2020

Abstract: Chronic exposure to inorganic arsenic is associated with a variety of adverse health effects, including lung, bladder, kidney, and liver cancer. Se... Read more »

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ChIP-seq
Frataxin gene editing rescues Friedreich's ataxia pathology in dors...
Published: August, 2020

Abstract: Friedreich's ataxia (FRDA) is an autosomal-recessive neurodegenerative and cardiac disorder which occurs when transcription of the FXN gene is sile... Read more »

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MagMeDIP kit Antibody
Combined treatment with CBP and BET inhibitors reverses inadvertent...
Published: August, 2020

Abstract: Diffuse intrinsic pontine gliomas (DIPG) are the most aggressive brain tumors in children with 5-year survival rates of only 2%. About 85% of all D... Read more »

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Bioruptor Antibody Microplex Library Preparation kit
Human papillomavirus type 38 alters wild-type p53 activity to promo...
Published: August, 2020

Abstract: Tumor suppressors can exert pro-proliferation functions in specific contexts. In the beta human papillomavirus type 38 (HPV38) experimental model, ... Read more »

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Chromatin Shearing IP-Star Compact iDeal ChIP-seq Kit for Histones
A gene therapy for inherited blindness using dCas9-VPR–mediatedtran...
Published: August, 2020

Abstract: Catalytically inactive dCas9 fused to transcriptional activators (dCas9-VPR) enables activation of silent genes. Many disease genes have counterpar... Read more »

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Antibody CRISPR
Differential Expression of Members of SOX Family of Transcription F...
Published: August, 2020

Abstract: Background: The Sry-related high-mobility-group box (SOX) gene family, with 20 known transcription factors in humans, plays essential roles during ... Read more »

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Antibody
Targeting DNA methylation depletes uterine leiomyoma stem-cell enri...
Published: August, 2020

Abstract: Uterine leiomyoma is the most common tumor in women and can cause severe morbidity. Leiomyoma growth requires maintenance and proliferation of a st... Read more »

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MethylCap
Integrated analysis of DNA methylation profile of HLA-G gene andima...
Published: August, 2020

Abstract: AIMS: Immune endothelial inflammation, underlying coronary heart disease (CHD) related phenotypes, could provide new insight into the pathobiology ... Read more »

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MagMeDIP kit
The transcription factor scleraxis differentially regulates gene ex...
Published: August, 2020

Abstract: The transcription factor scleraxis (SCX) is expressed throughout tendon development and plays a key role in directing tendon wound healing. However... Read more »

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Antibody iDeal ChIP-qPCR
DNA CpG methylation in sequential glioblastoma specimens.
Published: August, 2020

Abstract: PURPOSE: Glioblastoma is the most aggressive form of brain tumors. A better understanding of the molecular mechanisms leading to its evolution is e... Read more »

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Premium RRBS Kit
N-Methyladenosine co-transcriptionally directs the demethylation of...
Published: August, 2020

Abstract: A dynamic epigenome is critical for appropriate gene expression in development and health. Central to this is the intricate process of transcriptio... Read more »

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Bioruptor iDeal ChIP-seq Kit for Histones
Complete Genome Sequence of the Type Strain Pectobacterium punjaben...
Published: August, 2020

Abstract: Pectobacterium punjabense is a newly described species causing blackleg disease in potato plants. Therefore, by the combination of long (Oxford Nan... Read more »

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Megaruptor
Inhibition of the SET8 Pathway Ameliorates Lung Fibrosis Even Throu...
Published: August, 2020

Abstract: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown etiopathogenesis. The activation of extracellular matrix (ECM)-producing myo... Read more »

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Antibody
Comparative DNA methylome analysis of estrus ewes reveals the compl...
Published: August, 2020

Abstract: BACKGROUND/AIMS: Sheep are important livestock with variant ovulation rate and fertility. Dorset sheep is a typical breed with low prolificacy, whe... Read more »

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MagMeDIP kit
Methylation in pericytes after acute injury promotes chronic kidney...
Published: August, 2020

Abstract: The origin and fate of renal myofibroblasts is not clear after acute kidney injury (AKI). Here, we demonstrate that myofibroblasts were activated f... Read more »

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Bioruptor MagMeDIP kit
PR-DUB maintains expression of critical genes through FOXK1/2 andAS...
Published: August, 2020

Abstract: Polycomb group proteins are important for maintaining gene expression patterns and cell identity in metazoans. The mammalian Polycomb repressive de... Read more »

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Antibody
Integrative Omics Analyses Reveal Epigenetic Memory in Diabetic Ren...
Published: August, 2020

Abstract: Diabetic kidney disease (DKD) is a major complication of diabetes and the leading cause of end-stage renal failure. Epigenetics has been associated... Read more »

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Antibody
Exploring the virulence gene interactome with CRISPR/dCas9 in the h...
Published: August, 2020

Abstract: Mutually exclusive expression of the var multigene family is key to immune evasion and pathogenesis in Plasmodium falciparum, but few factors have ... Read more »

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Bioruptor Antibody Microplex Library Preparation kit
Targeted bisulfite sequencing for biomarker discovery.
Published: August, 2020

Abstract: Cytosine methylation is one of the best studied epigenetic modifications. In mammals, DNA methylation patterns vary among cells and is mainly found... Read more »

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Bioruptor
Tissue-Specific In Vivo Biotin Chromatin Immunoprecipitation withSe...
Published: July, 2020

Abstract: Chromatin immunoprecipitation with sequencing (ChIP-seq) has been instrumental in understanding transcription factor (TF) binding during gene regul... Read more »

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Microplex Library Preparation kit
The gut microbiome switches mutant p53 from tumour-suppressive toon...
Published: July, 2020

Abstract: Somatic mutations in p53, which inactivate the tumour-suppressor function of p53 and often confer oncogenic gain-of-function properties, are very c... Read more »

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Microplex Library Preparation kit
Distinct and temporary-restricted epigenetic mechanisms regulate hu...
Published: July, 2020

Abstract: The development of TCRαβ and TCRγδ T cells comprises a step-wise process in which regulatory events control differentiation ... Read more »

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ChIP-seq Antibody
OxLDL-mediated immunologic memory in endothelial cells.
Published: July, 2020

Abstract: Trained innate immunity describes the metabolic reprogramming and long-term proinflammatory activation of innate immune cells in response to differ... Read more »

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Antibody
Sizing, stabilising, and cloning repeat-expansions for gene targeti...
Published: July, 2020

Abstract: Aberrant microsatellite repeat-expansions at specific loci within the human genome cause several distinct, heritable, and predominantly neurologica... Read more »

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Megaruptor
Integrated epigenetic biomarkers in circulating cell-free DNA as a ...
Published: July, 2020

Abstract: BACKGROUND: The high lethal rate of pancreatic cancer is partly due to a lack of efficient biomarkers for screening and early diagnosis. We attempt... Read more »

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MagMeDIP kit IPure kit
The CDK4/6-EZH2 pathway is a potential therapeutic target for psori...
Published: July, 2020

Abstract: Psoriasis is a frequent inflammatory skin disease characterized by keratinocyte hyperproliferation and a disease-related infiltration of immune cel... Read more »

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Antibody
The Human Integrator Complex Facilitates Transcriptional Elongation...
Published: July, 2020

Abstract: Transcription by RNA polymerase II (RNAPII) is pervasive in the human genome. However, the mechanisms controlling transcription at promoters and en... Read more »

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Antibody ChIP Cross-link Gold
Prostate cancer reactivates developmental epigenomic programs durin...
Published: July, 2020

Abstract: Epigenetic processes govern prostate cancer (PCa) biology, as evidenced by the dependency of PCa cells on the androgen receptor (AR), a prostate ma... Read more »

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Antibody

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