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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Multi-omics phenotyping of the gut-liver axis reveals metabolicpert...
Published: April, 2021

Abstract: Health effects of pesticides are not always accurately detected using the current battery of regulatory toxicity tests. We compared standard histop... Read more »

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Premium RRBS Kit
Chd8 regulates X chromosome inactivation in mouse through fine-tuni...
Published: April, 2021

Abstract: Female mammals achieve dosage compensation by inactivating one of their two X chromosomes during development, a process entirely dependent on Xist,... Read more »

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Antibody
Comparative analysis of histone H3K4me3 modifications between blast...
Published: April, 2021

Abstract: Epigenetic changes induced in the early developmental stages by the surrounding environment can have not only short-term but also long-term consequ... Read more »

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Antibody
Genetic perturbation of PU.1 binding and chromatin looping at neutr...
Published: April, 2021

Abstract: Neutrophils play fundamental roles in innate immune response, shape adaptive immunity, and are a potentially causal cell type underpinning genetic ... Read more »

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Antibody
Epigenomic landscape of human colorectal cancer unveils an aberrant...
Published: April, 2021

Abstract: Cancer is characterized by pervasive epigenetic alterations with enhancer dysfunction orchestrating the aberrant cancer transcriptional programs an... Read more »

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Antibody
Complete vertebrate mitogenomes reveal widespread repeats and gened...
Published: April, 2021

Abstract: BACKGROUND: Modern sequencing technologies should make the assembly of the relatively small mitochondrial genomes an easy undertaking. However, few... Read more »

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Megaruptor
Polycomb Repressive Complex 2 and KRYPTONITE regulate pathogen-indu...
Published: April, 2021

Abstract: The Polycomb Repressive Complex 2 (PRC2) is well-known for its role in controlling developmental transitions by suppressing the premature expressio... Read more »

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Antibody Microplex Library Preparation kit
Polycystic ovary syndrome is transmitted via a transgenerational ep...
Published: March, 2021

Abstract: Polycystic ovary syndrome (PCOS) is the most common reproductive and metabolic disorder affecting women of reproductive age. PCOS ha... Read more »

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DNA Methylation
Genome-wide DNA methylation and transcriptome integration reveal di...
Published: March, 2021

Abstract: Nearly all human complex traits and diseases exhibit some degree of sex differences, and epigenetics contributes to these differences as DNA methyl... Read more »

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DNA methylation microarray Muscle metabolism Epigenetic sex difference
Cell-free DNA methylome profiling by MBD-seq with ultra-low input
Published: March, 2021

Abstract: Methylation signatures in cell-free DNA (cfDNA) have shown great sensitivity and specificity in the characterization of tumour status and classific... Read more »

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DNA Methylation Liquid biopsy cfDNA Next-generation sequencing Methyl binding protein MBD-seq cfMBD-seq MethylCap kit
Comparison of long read sequencing technologies in interrogating ba...
Published: March, 2021

Abstract: The newest generation of DNA sequencing technology is highlighted by the ability to generate sequence reads hundreds of kilobases in length. Pacifi... Read more »

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Megaruptor
Fra-1 regulates its target genes via binding to remote enhancers wi...
Published: March, 2021

Abstract: The ubiquitous family of dimeric transcription factors AP-1 is made up of Fos and Jun family proteins. It has long been thought to operate principa... Read more »

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Antibody
Loss of SETD1B results in the redistribution of genomic H3K4me3 in ...
Published: March, 2021

Abstract: Histone 3 lysine 4 trimethylation (H3K4me3) is an epigenetic mark found at gene promoters and CpG islands. H3K4me3 is essential for mammalian devel... Read more »

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Antibody Microplex Library Preparation kit
Cell-specific alterations inPitx1regulatory landscape activation ca...
Published: March, 2021

Abstract: Most developmental genes rely on multiple transcriptional enhancers for their accurate expression during embryogenesis. Because enhancers may have ... Read more »

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Antibody
Chromosomal rearrangements but no change of genes and transposable ...
Published: March, 2021

Abstract: Chromosomal rearrangements have been largely described among eukaryotes, and may have important consequences on evolution of species. High genome p... Read more »

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Megaruptor
Transgenic mice for in vivo epigenome editing with CRISPR-based sys...
Published: March, 2021

Abstract: The discovery, characterization, and adaptation of the RNA-guided clustered regularly interspersed short palindromic repeat (CRISPR)-Cas9 system ha... Read more »

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Antibody CRISPR
The aging DNA methylome reveals environment-by-aging interactions i...
Published: March, 2021

Abstract: The rate at which individuals age underlies variation in life history and attendant health and disease trajectories. Age specific patterning of the... Read more »

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Premium RRBS Kit
Unique Patterns of H3K4me3 and H3K27me3 in 2-Cell-like Embryonic St...
Published: March, 2021

Abstract: A small subgroup of embryonic stem cells (ESCs) exhibit molecular features similar to those of two-cell embryos (2C). However, it remains elusive w... Read more »

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Antibody
Epigenomic tensor predicts disease subtypes and reveals constrained...
Published: March, 2021

Abstract: Understanding the epigenomic evolution and specificity of disease subtypes from complex patient data remains a major biomedical problem. We here pr... Read more »

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Antibody
Transcriptional programming drives Ibrutinib-resistance evolution i...
Published: March, 2021

Abstract: Ibrutinib, a bruton's tyrosine kinase (BTK) inhibitor, provokes robust clinical responses in aggressive mantle cell lymphoma (MCL), yet many patien... Read more »

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Antibody
Polycystic ovary syndrome is transmitted via a transgenerational ep...
Published: March, 2021

Abstract: Polycystic ovary syndrome (PCOS) is the most common reproductive and metabolic disorder affecting women of reproductive age. PCOS has a strong heri... Read more »
A regulatory variant at 3q21.1 confers an increased pleiotropic ris...
Published: March, 2021

Abstract: Skeletal and glycemic traits have shared etiology, but the underlying genetic factors remain largely unknown. To identify genetic loci that may hav... Read more »

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Antibody
The insecticide permethrin induces transgenerational behavioral cha...
Published: March, 2021

Abstract: The pyrethroid insecticide permethrin is widely used for agricultural and domestic purposes. Previous data indicated that it acts as a developmenta... Read more »

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IP-Star Compact Premium RRBS Kit
Inactivating histone deacetylase HDA promotes longevity by mobilizi...
Published: March, 2021

Abstract: Histone acetylations are important epigenetic markers for transcriptional activation in response to metabolic changes and various stresses. Using t... Read more »

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True MicroChIP kit
A single nucleotide polymorphism variant located in the cis-regulat...
Published: March, 2021

Abstract: Avian egg coloration is shaped by natural selection, but its genetic basis remains unclear. Here, we used genome-wide association analysis and iden... Read more »

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Megaruptor
Functional annotations of three domestic animal genomes provide vit...
Published: March, 2021

Abstract: Gene regulatory elements are central drivers of phenotypic variation and thus of critical importance towards understanding the genetics of complex ... Read more »

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Antibody iDeal ChIP-seq Kit for Histones
VPRBP functions downstream of the androgen receptor and OGT to rest...
Published: February, 2021

Abstract: Androgen receptor (AR) is a major driver of prostate cancer (PCa) initiation and progression. O-GlcNAc transferase (OGT), the enzyme that catalyses... Read more »

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Microplex Library Preparation kit iDeal ChIP-seq Kit for Transcription Factors
Coordinated changes in gene expression, H1 variant distribution and...
Published: February, 2021

Abstract: Up to seven members of the histone H1 family may contribute to chromatin compaction and its regulation in human somatic cells. In breast cancer cel... Read more »

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IPure kit
Histone modification dynamics at H3K27 are associated with alteredt...
Published: February, 2021

Abstract: Transcriptional dynamic in response to environmental and developmental cues are fundamental to biology, yet many mechanistic aspects are poorly und... Read more »

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Antibody IPure kit
The histone modification H3K4me3 is altered at the locus in Alzhei...
Published: February, 2021

Abstract: Several epigenome-wide association studies of DNA methylation have highlighted altered DNA methylation in the gene in Alzheimer's disease (AD) brai... Read more »

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Antibody

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