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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

TGIF2 is a major regulator of neural stem cell fate and neurogenic ...
Published: February, 2025
Abstract: During brain development, neural stem cells (NSCs) must balance self-renewal with differentiation and ensure lineage progression. To identify novel... Read more »
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Microplex Library Preparation kit
CRISPR screening identifies regulators of enhancer-mediated androge...
Published: February, 2025
Abstract: Amplification of the androgen receptor (AR) locus is the most frequent alteration in metastatic castration-resistant prostate cancer (CRPC)... Read more »
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Antibody ATAC-seq
Transgenerational inheritance of diabetes susceptibility in male of...
Published: February, 2025
Abstract: Androgen exposure (AE) poses a profound health threat to women, yet its transgenerational impacts on male descendants remain unclear. Here, employi... Read more »
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MagMeDIP kit
Accelerated epigenetic aging in Huntington’s disease involves polyc...
Published: February, 2025
Abstract: Loss of epigenetic information during physiological aging compromises cellular identity, leading to de-repression of developmental genes. Here, we ... Read more »
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Antibody Microplex Library Preparation kit CUT&Tag
Combinatorial mapping of E3 ubiquitin ligases to their target subst...
Published: February, 2025
Abstract: Highlights Developed a combinatorial assay to test E3-substrate interactions at scale Identified known and unknown E3-substrate... Read more »
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Tagmentase
Using multiomic integration to improve blood biomarkers of major de...
Published: February, 2025
Abstract: Background Major depressive disorder (MDD) is a leading cause of disability, with a twofold increase in prevalence in women compared to men. Ove... Read more »
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Infinium Human MethylationEPIC Array Service
The assembly factor Reh1 is released from the ribosome during its i...
Published: February, 2025
Abstract: Assembly of functional ribosomal subunits and successfully delivering them to the translating pool is a prerequisite for protein synthesis and cell... Read more »
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D-Plex small RNA-seq
Effective in vivo binding energy landscape illustrates kinetic stab...
Published: February, 2025
Abstract: Transcription factors (TFs) such as RBPJ in Notch signaling bind to specific DNA sequences to regulate transcription. How TF-DNA binding kinetics a... Read more »
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Microplex Library Preparation kit
HDAC1 and HDAC2 are bidirectional enzymes that catalyze histone sor...
Published: January, 2025
Abstract: Reversible histone acylation is crucial for epigenetic gene expression regulation. Histone acylation is typically mediated by lysine acyltransferas... Read more »
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CUT&Tag
Bat genomes illuminate adaptations to viral tolerance and disease r...
Published: January, 2025
Abstract: Zoonoses are infectious diseases transmitted from animals to humans. Bats have been suggested to harbour more zoonotic viruses than any other mamma... Read more »
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Megaruptor
Chromatin environment-dependent effects of DOT1L on gene expression...
Published: January, 2025
Abstract: The H3K79 methyltransferase DOT1L is essential for multiple aspects of mammalian development where it has been shown to regulate gene expression. H... Read more »
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iDeal ChIP-seq Kit for Transcription Factors iDeal ChIP-seq Kit for Histones CUT&Tag
Trithorax regulates long-term memory in Drosophila through epigenet...
Published: January, 2025
Abstract: The role of epigenetics and chromatin in the maintenance of postmitotic neuronal cell identities is not well understood. Here, we show that the his... Read more »
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Antibody Microplex Library Preparation kit True MicroChIP kit
Time-dependent chromatin maturation during 3D spheroid culture impr...
Published: January, 2025
Abstract: Non-small cell lung cancer (NSCLC) is the deadliest cancer worldwide. Therapeutic progress stagnate, highlighting the complexity to replicate NSCLC... Read more »
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ChIPmentation
Cell type-specific eQTL detection from single-cell RNA-seq reveals ...
Published: January, 2025
Abstract: Gene regulatory networks (GRN) must be robust to maintain cellular identity across individuals yet flexible to accommodate population genetic varia... Read more »
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D-Plex small RNA-seq
Microbiota translocation following intestinal barrier disruption pr...
Published: January, 2025
Abstract: Highlights Gut barrier disruption induces trained immunity in bone marrow progenitors Enterococcus faecalis translocates t... Read more »
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Antibody CUT&Tag
Motif distribution and DNA methylation underlie distinct Cdx2 bindi...
Published: January, 2025
Abstract: Transcription factors guide tissue development by binding to developmental stage-specific targets and establishing an appropriate enhancer landscap... Read more »
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Antibody
Genome-wide transcriptome and DNA methylome profiling of acquired c...
Published: January, 2025
Abstract: Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) develops uniquely and frequently in patients receiving long-term dialysis for e... Read more »
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Infinium Human MethylationEPIC Array Service
Minimization of gene editing off-target effects by tissue restricti...
Published: January, 2025
Abstract: Therapeutic in vivo gene editing with highly specific nucleases has the potential to revolutionize treatment for a wide range of human di... Read more »
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Tagmentase
The senolytic cocktail, dasatinib and quercetin, impacts the chroma...
Published: January, 2025
Abstract: One promising strategy to alleviate aging symptoms is the treatment with senolytics that is compounds which selectively eliminate senescent cells. ... Read more »
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Antibody
Elevating RNA m5C methylation provides a promising strategy for cro...
Published: January, 2025
Abstract: RNA 5-methylcytidine (m5C) has been identified as a key epi-transcriptomic modification of mRNAs involved in regulating multiple post-transcription... Read more »
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DNA Methylation
Schistosoma mansoni antigen induced innate immune memory features m...
Published: January, 2025
Abstract: We have previously identified that S. mansoni infection induces a unique form of myeloid training that protects male but not female mice ... Read more »
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ATAC-seq
Accelerated epigenetic ageing after burn injury
Published: January, 2025
Abstract: Individuals who suffer a major burn injury are at higher risk of developing a range of age-associated diseases prematurely leading to an increase i... Read more »
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Infinium Human MethylationEPIC Array Service
m3C is a mitochondrial mRNA modification which promotes tumor progr...
Published: January, 2025
Abstract: Mitochondrial mRNA modifications are suggested to play a role in fine-tuning mitochondrial gene expression and function. However, the epitranscript... Read more »
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Antibody
Concurrent RB1 and P53 pathway disruption predisposes to the develo...
Published: January, 2025
Abstract: The foremost feature of glioblastoma (GBM), the most frequent malignant brain tumours in adults, is a remarkable degree of intra- and inter-tumour ... Read more »
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Infinium Human MethylationEPIC Array Service
Dynamic PRC1–CBX8 stabilizes a porous structure of chromatin conden...
Published: January, 2025
Abstract: Abstract The compaction of chromatin is a prevalent paradigm in gene repression. Chromatin compaction is commonly thought to repress transcripti... Read more »
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ATAC-seq
Maternal obesity alters histone modifications mediated by the inter...
Published: January, 2025
Abstract: Neurodevelopmental disorders have complex origins that manifest early during embryonic growth and are associated with intricate gene regulation dyn... Read more »
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Bioruptor
MARTRE family proteins negatively regulate CCR4-NOT activity to pro...
Published: January, 2025
Abstract: The mammalian early embryo development requires translation of maternal mRNA inherited from the oocyte. While poly(A) tail length influences mRNA t... Read more »
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D-Plex small RNA-seq
A20’s Linear Ubiquitin Binding Motif Restrains Pathogenic Activatio...
Published: January, 2025
Abstract: A20, encoded by the TNFAIP3 gene, is a protein linked to Crohn's disease and celiac disease in humans. We now find that mice expressing p... Read more »
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Tagmentase
MECOM is a master repressor of myeloid differentiation through dose...
Published: January, 2025
Abstract: Enhancer translocations, due to 3q26 rearrangements, drive out-of-context MECOM expression in an aggressive subtype of acute myeloid leukemia (AML)... Read more »
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Antibody Microplex Library Preparation kit
Dysregulation of Myelination in Focal Cortical Dysplasia Type II of...
Published: December, 2024
Abstract: Focal cortical dysplasias (FCDs) are local malformations of the human neocortex and a leading cause of intractable epilepsy. FCDs are classified in... Read more »
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IPure kit iDeal ChIP-seq Kit for Transcription Factors

イベント

  • American Association of Cancer Research (AACR)
    Chicago (IL), USA
    Apr 25-Apr 30, 2025
  • 14th International Symposium on Minimal Residual Cancer
    Nice, France
    May 7-May 9, 2025
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