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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

The histone H2B ubiquitin ligase RNF40 is required for HER2-drivenm...
Published: October, 2020

Abstract: The HER2-positive breast cancer subtype (HER2-BC) displays a particularly aggressive behavior. Anti-HER2 therapies have significantly improved the ... Read more »

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Antibody Microplex Library Preparation kit
RUNX3 methylation drives hypoxia-induced cell proliferation andanti...
Published: October, 2020

Abstract: Inactivation of tumor suppressor Runt-related transcription factor 3 (RUNX3) plays an important role during early tumorigenesis. However, posttrans... Read more »

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iDeal ChIP-seq Kit for Transcription Factors
StE(z)2, a Polycomb group methyltransferase and deposition of H3K27...
Published: October, 2020

Abstract: Polycomb Repressive Complex (PRC) group proteins regulate various developmental processes in plants by repressing the target genes via H3K27 trimet... Read more »

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Antibody
Priming for enhanced ARGONAUTE2 activation accompanies induced resi...
Published: October, 2020

Abstract: Systemic acquired resistance (SAR) is a broad-spectrum disease resistance response that can be induced upon infection from pathogens or by chemical... Read more »

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Antibody
Digging Deeper into Breast Cancer Epigenetics: Insights from Chemic...
Published: October, 2020

Abstract: Breast cancer is often sporadic due to several factors. Among them, the deregulation of epigenetic proteins may be involved. TIP60 or KAT5 is an ac... Read more »

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Antibody IP-Star Compact iDeal ChIP-seq Kit for Histones
Genome-wide DNA methylation analysis using MethylCap-seq in canineh...
Published: October, 2020

Abstract: DNA methylation is a comprehensively studied epigenetic modification and plays crucial roles in cancer development. In the present study, MethylCap... Read more »

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MethylCap
Polycomb Repressive Complex 2-mediated histone modification H3K27me...
Published: October, 2020

Abstract: Epigenetic reprogramming during germ cell formation is essential to gain pluripotency and thus embryogenic potential. The histone modification H3K2... Read more »

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Microplex Library Preparation kit
Genome structure and content of the rice root-knot nematode ().
Published: October, 2020

Abstract: Discovered in the 1960s, is a root-knot nematode species considered as a major threat to rice production. Yet, its origin, genomic structure, and i... Read more »

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Megaruptor
Transcription of CLDND1 in human brain endothelial cells is regulat...
Published: October, 2020

Abstract: Increased permeability of endothelial cells lining the blood vessels in the brain leads to vascular oedema and, potentially, to stroke. The tight j... Read more »

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OneDay ChIP Kit
Benchmarking DNA methylation assays in a reef-building coral.
Published: October, 2020

Abstract: Interrogation of chromatin modifications, such as DNA methylation, has the potential to improve forecasting and conservation of marine ecosystems. ... Read more »

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MethylCap
Super-enhancer switching drives a burst in gene expression at themi...
Published: October, 2020

Abstract: Owing to bursts in the expression of thousands of germline-specific genes, the testis has the most diverse and complex transcriptome of all organs.... Read more »

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IP-Star Compact
NSD1-deposited H3K36me2 directs de novo methylation in the mouse ma...
Published: October, 2020

Abstract: De novo DNA methylation (DNAme) in mammalian germ cells is dependent on DNMT3A and DNMT3L. However, oocytes and spermatozoa show distinct patterns ... Read more »

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Antibody
Repeat expansions confer WRN dependence in microsatellite-unstablec...
Published: October, 2020

Abstract: The RecQ DNA helicase WRN is a synthetic lethal target for cancer cells with microsatellite instability (MSI), a form of genetic hypermutability th... Read more »

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Megaruptor
MITF is a driver oncogene and potential therapeutic target in kidne...
Published: October, 2020

Abstract: Tuberous sclerosis complex (TSC) is an autosomal dominant tumor suppressor syndrome, characterized by tumor development in multiple organs, includi... Read more »

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Antibody
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Gr...
Published: October, 2020

Abstract: Trained immunity, a functional state of myeloid cells, has been proposed as a compelling immune-oncological target. Its efficient induction require... Read more »

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Antibody
Epigenetic Blockade of Hippocampal SOD2 Via DNMT3b-Mediated DNAMeth...
Published: October, 2020

Abstract: The recurrent events of mild trauma exacerbate the vulnerability for post-traumatic stress disorder; however, the underlying molecular mechanisms a... Read more »

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Antibody
p53 directly represses human LINE1 transposons.
Published: October, 2020

Abstract: p53 is a potent tumor suppressor and commonly mutated in human cancers. Recently, we demonstrated that p53 genes act to restrict retrotransposons i... Read more »

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Antibody
Radiation-induced H3K9 methylation on E-cadherin promoter mediated ...
Published: October, 2020

Abstract: Lung cancer patients who have undergone radiotherapy developed severe complications such as pneumonitis and fibrosis. Upon irradiation, epithelial ... Read more »

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iDeal ChIP-seq Kit for Histones
Formation of the CenH3-Deficient Holocentromere in Lepidoptera Avoi...
Published: October, 2020

Abstract: Despite the essentiality for faithful chromosome segregation, centromere architectures are diverse among eukaryotes and embody two main configurati... Read more »

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Antibody iDeal ChIP-seq Kit for Histones Beads
Network integration and modelling of dynamic drug responses at mult...
Published: October, 2020

Abstract: Uncovering cellular responses from heterogeneous genomic data is crucial for molecular medicine in particular for drug safety. This can be realized... Read more »

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MagMeDIP kit
Integrative Analysis of Glucometabolic Traits, Adipose Tissue DNA M...
Published: September, 2020

Abstract: Decline in insulin sensitivity due to dysfunction of adipose tissue (AT) is one of the earliest pathogenic events in Type 2 Diabetes. We hypothesiz... Read more »

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Premium RRBS Kit DNA Methylation Profiling (RRBS Service)
Genes with 5′ terminal oligopyrimidine tracts preferentially escape...
Published: September, 2020

Abstract: Viruses rely on the host translation machinery to synthesize their own proteins. Consequently, they have evolved varied mechanisms to co-opt host t... Read more »
Differential epigenetic regulation between the alternative promoter...
Published: September, 2020

Abstract: Multiple myeloma (MM) is a B-cell neoplasm that is characterized by the accumulation of malignant plasma cells in the bone marrow. The transcriptio... Read more »

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Premium Bisulfite Kit
Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pr...
Published: September, 2020

Abstract: The CRISPR-Cas9 system has increased the speed and precision of genetic editing in cells and animals. However, model generation for drug developmen... Read more »
Circuit-specific hippocampal ΔFosB underlies resilience to stress-i...
Published: September, 2020

Abstract: Chronic stress is a key risk factor for mood disorders like depression, but the stress-induced changes in brain circuit function and gene expressio... Read more »
UTX/KDM6A suppresses AP-1 and a gliogenesis program during neuraldi...
Published: September, 2020

Abstract: BACKGROUND: UTX/KDM6A is known to interact and influence multiple different chromatin modifiers to promote an open chromatin environment to facilit... Read more »

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Antibody
Between-Generation Phenotypic and Epigenetic Stability in a Clonal ...
Published: September, 2020

Abstract: Epigenetic variation might play an important role in generating adaptive phenotypes by underpinning within-generation developmental plasticity, per... Read more »

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Antibody
RNF40 exerts stage-dependent functions in differentiating osteoblas...
Published: September, 2020

Abstract: The role of histone ubiquitination in directing cell lineage specification is only poorly understood. Our previous work indicated a role of the his... Read more »

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Microplex Library Preparation kit
Breakpoint mapping of a t(9;22;12) chronic myeloid leukaemia patien...
Published: September, 2020

Abstract: BACKGROUND: The genetic changes in chronic myeloid leukaemia (CML) have been well established, although challenges persist in cases with rare fusio... Read more »

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Megaruptor
Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptiv...
Published: September, 2020

Abstract: SWI/SNF chromatin remodelers play critical roles in development and cancer. The causal links between SWI/SNF complex disassembly and carcinogenesis... Read more »

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Antibody

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