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Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Non-coding somatic mutations converge on the PAX8 pathway in ovaria...
Published: April, 2020

Abstract: The functional consequences of somatic non-coding mutations in ovarian cancer (OC) are unknown. To identify regulatory elements (RE) and genes pert... Read more »

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Antibody
Unique Role of Histone Methyltransferase PRDM8 in the Tumorigenesis...
Published: April, 2020

Abstract: Merkel cell carcinoma (MCC) is a deadly skin cancer, and about 80% of its cases have been shown to harbor integrated Merkel polyomavirus in the tum... Read more »

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Beads
The endocannabinoid anandamide has an anti-inflammatory effect on C...
Published: April, 2020

Abstract: Endocannabinoids are important lipid-signaling mediators. Both protective and deleterious effects of endocannabinoids in the cardiovascular system ... Read more »

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Beads
CRISPR off-target detection with DISCOVER-seq.
Published: April, 2020

Abstract: DISCOVER-seq (discovery of in situ Cas off-targets and verification by sequencing) is a broadly applicable approach for unbiased CRISPR-Cas off-tar... Read more »

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iDeal ChIP-seq Kit for Transcription Factors
An epigenetic map of malaria parasite development from host to vector.
Published: April, 2020

Abstract: The malaria parasite replicates asexually in the red blood cells of its vertebrate host employing epigenetic mechanisms to regulate gene expression... Read more »

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Antibody
The TGF-β profibrotic cascade targets ecto-5'-nucleotidase gene in ...
Published: April, 2020

Abstract: Progressive diabetic nephropathy (DN) and loss of renal function correlate with kidney fibrosis. Crosstalk between TGF-β and adenosinergic sig... Read more »

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Antibody
Abo1 is required for the H3K9me2 to H3K9me3 transition in heterochr...
Published: April, 2020

Abstract: Heterochromatin regulation is critical for genomic stability. Different H3K9 methylation states have been discovered, with distinct roles in hetero... Read more »

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Antibody
Genome-Wide DNA Methylation Profiling in Early Stage I Lung Adenoca...
Published: April, 2020

Abstract: INTRODUCTION: Surgical procedure is the treatment of choice in early stage I lung adenocarcinoma. However, a considerable number of patients experi... Read more »

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IP-Star Compact
Endogenous retroviruses are a source of enhancers with oncogenic po...
Published: April, 2020

Abstract: Acute myeloid leukemia (AML) is a highly aggressive hematopoietic malignancy, defined by a series of genetic and epigenetic alterations, which resu... Read more »

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Antibody
TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-...
Published: March, 2020

Abstract: Loss-of-function mutations in the SDHB subunit of succinate dehydrogenase predispose patients to aggressive tumors characterized by pseudohypo... Read more »

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MagMeDIP kit Antibody iDeal ChIP-qPCR
CRISPR-based gene knockout screens reveal deubiquitinases involved ...
Published: March, 2020

Abstract: The major barrier to a HIV-1 cure is the persistence of latent genomes despite treatment with antiretrovirals. To investigate host factors which pr... Read more »

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Antibody CRISPR
Differential modulation of the androgen receptor for prostate cance...
Published: March, 2020

Abstract: Androgen receptor (AR) action is a hallmark of prostate cancer (PCa) with androgen deprivation being standard therapy. Yet, resistance arises and a... Read more »

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Antibody IPure kit
High density of unrepaired genomic ribonucleotides leads to Topoiso...
Published: March, 2020

Abstract: Cellular levels of ribonucleoside triphosphates (rNTPs) are much higher than those of deoxyribonucleoside triphosphates (dNTPs), thereby influencin... Read more »

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Antibody
Multi-omic analysis of gametogenesis reveals a novel signature at t...
Published: March, 2020

Abstract: Epigenetic regulation of gene expression is tightly controlled by the dynamic modification of histones by chemical groups, the diversity of which h... Read more »

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IP-Star Compact Microplex Library Preparation kit iDeal ChIP-seq Kit for Histones Chromatin Profiling (ChIP-seq) Services
Alu retrotransposons modulate Nanog expression through dynamic chan...
Published: March, 2020

Abstract: Transcriptional repression of Nanog is an important hallmark of stem cell differentiation. Chromatin modifications have been linked to the epigenet... Read more »

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Antibody
Anti-adipogenic signals at the onset of obesity-related inflammatio...
Published: March, 2020

Abstract: Chronic inflammation that affects primarily metabolic organs, such as white adipose tissue (WAT), is considered as a major cause of human obesity-a... Read more »

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Microplex Library Preparation kit
LXR Activation Induces a Proinflammatory Trained Innate Immunity-Ph...
Published: March, 2020

Abstract: The concept of trained innate immunity describes a long-term proinflammatory memory in innate immune cells. Trained innate immunity is regulated th... Read more »

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Antibody
LY75 Ablation Mediates Mesenchymal-Epithelial Transition (MET) in E...
Published: March, 2020

Abstract: Growing evidence demonstrates that epithelial-mesenchymal transition (EMT) plays an important role in epithelial ovarian cancer (EOC) progression a... Read more »

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DNA Methylation Profiling (RRBS Service)
CDK7 Inhibition is Effective in all the Subtypes of Breast Cancer: ...
Published: March, 2020

Abstract: CDK7, a transcriptional cyclin-dependent kinase, is emerging as a novel cancer target. Triple-negative breast cancers (TNBC) but not estrogen recep... Read more »

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Antibody
Genome-wide DNA Methylation Analysis of Mantle Edge and Mantle Cent...
Published: March, 2020

Abstract: DNA methylation is a type of epigenetic modification that alters gene expression without changing the DNA sequence and mediates some cases of pheno... Read more »

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MagMeDIP kit
Dnmt3a and Dnmt3b-Decommissioned Fetal Enhancers are Linked to Kidn...
Published: March, 2020

Abstract: BACKGROUND: Cytosine methylation is an epigenetic mark that dictates cell fate and response to stimuli. The timing and establishment of methylation... Read more »

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Premium RRBS Kit
ChromID identifies the protein interactome at chromatin marks.
Published: March, 2020

Abstract: Chromatin modifications regulate genome function by recruiting proteins to the genome. However, the protein composition at distinct chromatin modif... Read more »

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Antibody
Human cardiac fibrosis-on-a-chip model recapitulates disease hallma...
Published: March, 2020

Abstract: While interstitial fibrosis plays a significant role in heart failure, our understanding of disease progression in humans is limited. To address th... Read more »

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CATS
HDAC3 functions as a positive regulator in Notch signal transduction.
Published: February, 2020

Abstract: Aberrant Notch signaling plays a pivotal role in T-cell acute lymphoblastic leukemia (T-ALL) and chronic lymphocytic leukemia (CLL). Amplitude and ... Read more »

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Antibody Microplex Library Preparation kit
A MORC-driven transcriptional switch controls Toxoplasma developmen...
Published: February, 2020

Abstract: Toxoplasma gondii has a complex life cycle that is typified by asexual development that takes place in vertebrates, and sexual reproduction, which ... Read more »

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Antibody IPure kit iDeal ChIP-seq Kit for Histones Beads
Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate...
Published: February, 2020

Abstract: Iron homeostasis is essential for maintaining cellular function in a wide range of cell types. However, whether iron affects the thermogenic proper... Read more »

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Antibody True MicroChIP kit
Recombination may occur in the absence of transcription in the immu...
Published: February, 2020

Abstract: Developing B cells undergo V(D)J recombination to generate a vast repertoire of Ig molecules. V(D)J recombination is initiated by the RAG1/RAG2 com... Read more »

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Antibody Premium Bisulfite Kit
Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-...
Published: February, 2020

Abstract: Aberrant activation of the TAL1 is associated with up to 60% of T-ALL cases and is involved in CTCF-mediated genome organization within the TAL1 lo... Read more »

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Antibody
DNA Methylation Editing by CRISPR-guided Excision of 5-Methylcytosine.
Published: February, 2020

Abstract: Tools for actively targeted DNA demethylation are required to increase our knowledge about regulation and specific functions of this important epig... Read more »

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Antibody CRISPR
STAT Signaling Modifies Ascl1 Chromatin Binding and Limits Neural R...
Published: February, 2020

Abstract: Müller glia (MG) serve as sources for retinal regeneration in non-mammalian vertebrates. We find that this process can be induced in mous... Read more »

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LowCell ChIP kit

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