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断片化技術
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クロマチン機能
クロマチン断片化
クロマチン免疫沈降
ChIPmentation™
CUT&Tag
ATAC-seq
DNAメチル化
バイサルファイト変換
メチル化DNA免疫沈降
Methylbinding domain proteinアッセイ
Hydroxymethylated DNA Immunoprecipitation
ゲノム編集CRISPR/Cas9
ChIPによるガイドRNAの選択
抗体
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サンプルサイズ抗体
ChIP-seq グレードの抗体
ChIPグレード抗体
Western Blot Antibodies
DNA修飾
RNA修飾
CRISPR / Cas9抗体
CUT&Tag Antibodies
NGSライブラリー調製
ChIP-seqライブレリー調製
RNA-seqのライブラリー調製
DNAシーケンシングのライブレリー調製
Tagmentation
試薬
Primer indexes for tagmented libraries
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ChIPmentation
7 publications found.
Time-dependent chromatin maturation during 3D spheroid culture improves preclinical modeling of non-small cell lung cancer
Published:
January, 2025
Abstract:
Non-small cell lung cancer (NSCLC) is the deadliest cancer worldwide. Therapeutic progress stagnate, highlighting the complexity to replicate NSCLC in preclinical models. Drug discovery studies rely mostly on cancer cells in two-dimension (2D), wh...
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Epigenetics and suicide: investigating altered H3K14ac unveiled differential expression in ADORA2A, B4GALT2 and MMP14
Published:
March, 2024
Abstract:
Background: Environmental factors make an important contribution to suicide. Histone tails are prone to different modifications, leading to changes of chromatin (de)condensation and consequently gene expression. Materials & methods:&...
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Multiomics uncovers the epigenomic and transcriptomic response to viral and bacterial stimulation in turbot
Published:
February, 2024
Abstract:
Uncovering the epigenomic regulation of immune responses is essential for a comprehensive understanding of host defence mechanisms but remains poorly described in farmed fish. Here, we report the first annotation of the innate immune regulatory re...
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A dataset of definitive endoderm and hepatocyte differentiations fromhuman induced pluripotent stem cells.
Published:
February, 2023
Abstract:
Hepatocytes are a major parenchymal cell type in the liver and play an essential role in liver function. Hepatocyte-like cells can be differentiated in vitro from induced pluripotent stem cells (iPSCs) via definitive endoderm (DE)-like cells and h...
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GATA6 is predicted to regulate DNA methylation in an in vitro model ofhuman hepatocyte differentiation.
Published:
May, 2022
Abstract:
Hepatocytes are the dominant cell type in the human liver, with functions in metabolism, detoxification, and producing secreted proteins. Although gene regulation and master transcription factors involved in the hepatocyte differentiation have bee...
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Rhesus macaques self-curing from a schistosome infection can displaycomplete immunity to challenge
Published:
October, 2021
Abstract:
The rhesus macaque provides a unique model of acquired immunity against schistosomes, which afflict \>200 million people worldwide. By monitoring bloodstream levels of parasite-gut-derived antigen, we show that from week 10 onwards an establish...
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Niche stiffening compromises hair follicle stem cell potential duringageing by reducing bivalent promoter accessibility.
Published:
July, 2021
Abstract:
Tissue turnover requires activation and lineage commitment of tissue-resident stem cells (SCs). These processes are impacted by ageing, but the mechanisms remain unclear. Here, we addressed the mechanisms of ageing in murine hair follicle SCs (HFS...
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