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12 publications found.

Transcription factor EGR2 controls homing and pathogenicity of T17cells in the central nervous system.
Published: August, 2023

Abstract: CD4 T helper 17 (T17) cells protect barrier tissues but also trigger autoimmunity. The mechanisms behind these opposing processes remain unclear. Here, we found that the transcription factor EGR2 controlled the transcriptional program of pathogeni...
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Spatial epigenome-transcriptome co-profiling of mammalian tissues.
Published: April, 2023

Abstract: Emerging spatial technologies, including spatial transcriptomics and spatial epigenomics, are becoming powerful tools for profiling of cellular states in the tissue context. However, current methods capture only one layer of omics information at a...
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Retrospective analysis of enhancer activity and transcriptome history.
Published: February, 2023

Abstract: Cell state changes in development and disease are controlled by gene regulatory networks, the dynamics of which are difficult to track in real time. In this study, we used an inducible DCM-RNA polymerase subunit b fusion protein which labels activ...
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The Hdc GC box is critical for Hdc gene transcription andhistamine-mediated anaphylaxis.
Published: February, 2023

Abstract: BACKGROUND: Histamine is a critical mediator of anaphylaxis, a neurotransmitter, and a regulator of gastric acid secretion. Histidine decarboxylase is a rate-limiting enzyme for histamine synthesis. However, in vivo regulation of Hdc, the gene tha...
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Simultaneous profiling of histone modifications and DNA methylation viananopore sequencing.
Published: December, 2022

Abstract: The interplay between histone modifications and DNA methylation drives the establishment and maintenance of the cellular epigenomic landscape, but it remains challenging to investigate the complex relationship between these epigenetic marks across...
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A SOX2-engineered epigenetic silencer factor represses the glioblastomagenetic program and restrains tumor development.
Published: August, 2022

Abstract: Current therapies remain unsatisfactory in preventing the recurrence of glioblastoma multiforme (GBM), which leads to poor patient survival. By rational engineering of the transcription factor SOX2, a key promoter of GBM malignancy, together with ...
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Spatially resolved epigenome-transcriptome co-profiling of mammalian tissues at the cellular level
Published: June, 2022

Abstract: Emerging spatial technologies including spatial transcriptomics and spatial epigenomics are becoming powerful tools for profiling cellular states in the tissue context. However, current methods capture only one layer of omics information at a time...
Read more »

Caffeine intake exerts dual genome-wide effects on hippocampal metabolismand learning-dependent transcription.
Published: June, 2022

Abstract: Caffeine is the most widely consumed psychoactive substance in the world. Strikingly, the molecular pathways engaged by its regular consumption remain unclear. We herein addressed the mechanisms associated with habitual (chronic) caffeine consumpt...
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Spatially resolved epigenomic profiling of single cells in complex tissues
Published: February, 2022

Abstract: The recent development of spatial omics methods enables single-cell profiling of the transcriptome and the 3D genome organization in a spatially resolved manner. Expanding the repertoire of spatial omics tools, a spatial epigenomics method will ac...
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ATRX regulates glial identity and the tumor microenvironment inIDH-mutant glioma
Published: November, 2021

Abstract: Background Recent single-cell transcriptomic studies report that IDH-mutant gliomas share a common hierarchy of cellular phenotypes, independent of genetic subtype. However, the genetic differences between IDH-mutant glioma subtypes are prognostic...
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Autocrine Vitamin D-signaling switches off pro-inflammatory programsof Th1 cells
Published: October, 2021

Abstract: The molecular mechanisms governing orderly shutdown and retraction of CD4+ T helper (Th)1 responses remain poorly understood. Here, we show that complement triggers contraction of Th1 responses by inducing intrinsic expression of the vitamin D (Vi...
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PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation
Published: October, 2021

Abstract: PIWI proteins are known as mediators of transposon silencing in animal germlines but are also found in adult pluripotent stem cells of highly regenerative animals, where they are essential for regeneration. Study of the nuclear PIWI protein SMEDWI...
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