CRISPR off-target detection with DISCOVER-seq. Published: April, 2020 Abstract:
DISCOVER-seq (discovery of in situ Cas off-targets and verification by sequencing) is a broadly applicable approach for unbiased CRISPR-Cas off-target identification in cells and tissues. It leverages the recruitment of DNA repair factors to doubl... Read more »
17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Published: October, 2019 Abstract:
Heat Shock Factor 1 (HSF1) is a key regulator of gene expression during acute environmental stress that enables the cell survival, which is also involved in different cancer-related processes. A high level of HSF1 in estrogen receptor (ER)-positiv... Read more »
Guidelines for optimized gene knockout using CRISPR/Cas9 Published: May, 2019 Abstract:
CRISPR/Cas9 technology has evolved as the most powerful approach to generate genetic models both for fundamental and preclinical research. Despite its apparent simplicity, the outcome of a genome-editing experiment can be substantially impacted by... Read more »
The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis. Published: August, 2018 Abstract:
Chromatin remodeler Brahma related gene 1 (BRG1) is silenced in approximately 10% of human pancreatic ductal adenocarcinomas (PDAs). We previously showed that BRG1 inhibits the formation of intraductal pancreatic mucinous neoplasm (IPMN) and that ... Read more »
Corticosteroid receptors adopt distinct cyclical transcriptional signatures Published: May, 2018 Abstract:
Mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) are two closely related hormone-activated transcription factors that regulate major pathophysiologic functions. High homology between these receptors accounts for the crossbindin... Read more »
Corticosteroid receptors adopt distinct cyclical transcriptional signatures. Published: May, 2018 Abstract:
Mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) are two closely related hormone-activated transcription factors that regulate major pathophysiologic functions. High homology between these receptors accounts for the crossbindin... Read more »
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