MYCN amplification and ATRX mutations are incompatible in neuroblastoma. Published: February, 2020 Abstract:
Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene correl... Read more »
Trained immunity modulates inflammation-induced fibrosis. Published: December, 2019 Abstract:
Chronic inflammation and fibrosis can result from inappropriately activated immune responses that are mediated by macrophages. Macrophages can acquire memory-like characteristics in response to antigen exposure. Here, we show the effect of BCG or ... Read more »
Nucleome Dynamics during Retinal Development. Published: August, 2019 Abstract:
More than 8,000 genes are turned on or off as progenitor cells produce the 7 classes of retinal cell types during development. Thousands of enhancers are also active in the developing retinae, many having features of cell- and developmental stage-... Read more »
The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer. Published: January, 2019 Abstract:
We identified a regulatory system that acts downstream of Wnt/β-catenin signaling in salivary gland and head and neck carcinomas. We show in a mouse tumor model of K14-Cre-induced Wnt/β-catenin gain-of-function and Bmpr1a loss-of-functio... Read more »
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