Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis. Published: December, 2020 Abstract:
Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and show exquisite regional and temporal specificity, suggesting a developmental context permissive to their effects. Here we show that 50\% of G34R/V tumors (n&nbs... Read more »
Macrophage Immune Memory Controls Endometriosis in Mice and Humans. Published: November, 2020 Abstract:
Endometriosis is a frequent, chronic, inflammatory gynecological disease characterized by the presence of ectopic endometrial tissue causing pain and infertility. Macrophages have a central role in lesion establishment and maintenance by driving c... Read more »
N-Methyladenosine co-transcriptionally directs the demethylation of histoneH3K9me2. Published: August, 2020 Abstract:
A dynamic epigenome is critical for appropriate gene expression in development and health. Central to this is the intricate process of transcription, which integrates cellular signaling with chromatin changes, transcriptional machinery and modific... Read more »
MYCN amplification and ATRX mutations are incompatible in neuroblastoma. Published: February, 2020 Abstract:
Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene correl... Read more »
Trained immunity modulates inflammation-induced fibrosis. Published: December, 2019 Abstract:
Chronic inflammation and fibrosis can result from inappropriately activated immune responses that are mediated by macrophages. Macrophages can acquire memory-like characteristics in response to antigen exposure. Here, we show the effect of BCG or ... Read more »
Nucleome Dynamics during Retinal Development. Published: August, 2019 Abstract:
More than 8,000 genes are turned on or off as progenitor cells produce the 7 classes of retinal cell types during development. Thousands of enhancers are also active in the developing retinae, many having features of cell- and developmental stage-... Read more »
The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer. Published: January, 2019 Abstract:
We identified a regulatory system that acts downstream of Wnt/β-catenin signaling in salivary gland and head and neck carcinomas. We show in a mouse tumor model of K14-Cre-induced Wnt/β-catenin gain-of-function and Bmpr1a loss-of-functio... Read more »
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