Physiological reprogramming in vivo mediated by Sox4 pioneer factoractivity Published: January, 2023 Abstract:
Tissue damage elicits cell fate switching through a process called metaplasia, but how the starting cell fate is silenced and the new cell fate is activated has not been investigated in animals. In cell culture, pioneer transcription factors media... Read more »
Optimized single-nucleus transcriptional profiling by combinatorialindexing. Published: October, 2022 Abstract:
Single-cell combinatorial indexing RNA sequencing (sci-RNA-seq) is a powerful method for recovering gene expression data from an exponentially scalable number of individual cells or nuclei. However, sci-RNA-seq is a complex protocol that has histo... Read more »
Spatial profiling of chromatin accessibility in mouse and human tissues Published: August, 2022 Abstract:
Cellular function in tissue is dependent on the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context1. The emergence of spatial transcriptomics has enabled genome-scale gene expression m... Read more »