Diagenode

Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Tra...
Published: May, 2019

Abstract: The gene regulatory network (GRN) of naive mouse embryonic stem cells (ESCs) must be reconfigured to enable lineage commitment. TCF3 sanctions rewi... Read more »

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Antibody
Guidelines for optimized gene knockout using CRISPR/Cas9
Published: May, 2019

Abstract: CRISPR/Cas9 technology has evolved as the most powerful approach to generate genetic models both for fundamental and preclinical research. Despite ... Read more »

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IP-Star Compact Microplex Library Preparation kit iDeal ChIP-seq Kit for Transcription Factors CRISPR
Interferon signature in patients with STAT1 gain-of-function mutati...
Published: May, 2019

Abstract: STAT1 gain-of-function (GOF) variants lead to defective Th17 cell development and chronic mucocutaneous candidiasis (CMC), but frequently also... Read more »

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IP-Star Compact
The Chromatin Factor HNI9 and ELONGATED HYPOCOTYL5 Maintain ROS Hom...
Published: May, 2019

Abstract: Reactive oxygen species (ROS) can accumulate in cells at excessive levels, leading to unbalanced redox states and to potential oxidative stress, wh... Read more »

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Antibody
Repression of Germline Genes in Somatic Tissues by H3K9 Dimethylat...
Published: May, 2019

Abstract: Repression of germline-promoting genes in somatic cells is critical for somatic development and function. To study how germline genes are repressed... Read more »

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IP-Star Compact
Long-range interactions between topologically associating domains s...
Published: May, 2019

Abstract: Genomic information is selectively used to direct spatial and temporal gene expression during differentiation. Interactions between topologically a... Read more »

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Antibody
Epigenetic control of the angiotensin-converting enzyme in endothel...
Published: May, 2019

Abstract: The angiotensin-converting enzyme (ACE) plays a central role in the renin-angiotensin system, which is involved in the regulation of blood pressure... Read more »

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MagMeDIP kit
Epigenetic modulation of a hardwired 3D chromatin landscape in two ...
Published: May, 2019

Abstract: The mechanisms underlying enhancer activation and the extent to which enhancer-promoter rewiring contributes to spatiotemporal gene expression are ... Read more »

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Antibody
Bromodomain inhibition of the coactivators CBP/EP300 facilitate cel...
Published: May, 2019

Abstract: Silencing of the somatic cell type-specific genes is a critical yet poorly understood step in reprogramming. To uncover pathways that maintain cell... Read more »

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Antibody
Canonical PRC1 controls sequence-independent propagation of Polycom...
Published: April, 2019

Abstract: Polycomb group (PcG) proteins play critical roles in the epigenetic inheritance of cell fate. The Polycomb Repressive Complexes PRC1 and PRC2 catal... Read more »

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Antibody
Genome-wide DNA methylation profiles in Tibetan and Yorkshire pigs ...
Published: April, 2019

Abstract: Background: Tibetan pigs, which inhabit the Tibetan Plateau, exhibit distinct phenotypic and physiological characteristics from those of lowland pi... Read more »

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MagMeDIP kit
P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Res...
Published: April, 2019

Abstract: DNA damage response (DDR) involves dramatic transcriptional alterations, the mechanisms of which remain ill defined. Here, we show that following g... Read more »

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Bioruptor
BRCA1 mutations attenuate super-enhancer function and chromatin loo...
Published: April, 2019

Abstract: BACKGROUND: BRCA1-associated breast cancer originates from luminal progenitor cells. BRCA1 functions in multiple biological processes, including do... Read more »

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Microplex Library Preparation kit
PML modulates H3.3 targeting to telomeric and centromeric repeats i...
Published: April, 2019

Abstract: Targeted deposition of histone variant H3.3 into chromatin is paramount for proper regulation of chromatin integrity, particularly in heterochromat... Read more »

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Antibody
Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecul...
Published: April, 2019

Abstract: Studies in vertebrates have outlined conserved molecular control of definitive endoderm (END) development. However, recent work also shows that key... Read more »

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Antibody
The Reference Genome Sequence of Scutellaria baicalensis Provides I...
Published: April, 2019

Abstract: Scutellaria baicalensis Georgi is important in Chinese traditional medicine where preparations of dried roots, "Huang Qin," are used for liver and ... Read more »

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Megaruptor
Long intergenic non-coding RNAs regulate human lung fibroblast func...
Published: April, 2019

Abstract: Phenotypic changes in lung fibroblasts are believed to contribute to the development of Idiopathic Pulmonary Fibrosis (IPF), a progressive and fata... Read more »

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Antibody iDeal ChIP-seq Kit for Histones
Defining UHRF1 Domains that Support Maintenance of Human Colon Canc...
Published: April, 2019

Abstract: UHRF1 facilitates the establishment and maintenance of DNA methylation patterns in mammalian cells. The establishment domains are defined, includin... Read more »

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Antibody
TET3 prevents terminal differentiation of adult NSCs by a non-catal...
Published: April, 2019

Abstract: Ten-eleven-translocation (TET) proteins catalyze DNA hydroxylation, playing an important role in demethylation of DNA in mammals. Remarkably, altho... Read more »

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Antibody
Dissecting the role of H3K27 acetylation and methylation in PRC2 me...
Published: April, 2019

Abstract: The Polycomb repressive complexes PRC1 and PRC2 act non-redundantly at target genes to maintain transcriptional programs and ensure cellular identi... Read more »

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Antibody
Essential Gene Profiles for Human Pluripotent Stem Cells Identify U...
Published: April, 2019

Abstract: Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding... Read more »

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Antibody
Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphoc...
Published: April, 2019

Abstract: Increased glycolysis parallels immune cell activation, but the role of pyruvate remains largely unexplored. We found that stimulation of dendritic ... Read more »

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Antibody
Identification of ADGRE5 as discriminating MYC target between Burki...
Published: April, 2019

Abstract: BACKGROUND: MYC is a heterogeneously expressed transcription factor that plays a multifunctional role in many biological processes such as cell pro... Read more »

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Antibody
A TetR-family transcription factor regulates fatty acid metabolism ...
Published: April, 2019

Abstract: Fatty acid metabolism and its regulation are known to play important roles in bacteria and eukaryotes. By contrast, although certain archaea appear... Read more »

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IPure kit
Assessment and site-specific manipulation of DNA (hydroxy-)methylat...
Published: April, 2019

Abstract: Dynamic changes in DNA (hydroxy-)methylation are fundamental for stem cell differentiation. However, the signature of these epigenetic marks in spe... Read more »

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MagMeDIP kit
The FZD7-TWIST1 axis is responsible for anoikis resistance and tumo...
Published: April, 2019

Abstract: Frizzled family receptor 7 (FZD7), a Wnt signaling receptor, is associated with the maintenance of stem cell properties and cancer progression. FZD... Read more »

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Antibody
Mitochondrial stress triggers a pro-survival response through epige...
Published: April, 2019

Abstract: Mitochondrial dysfunction represents an important cellular stressor and when intense and persistent cells must unleash an adaptive response to prev... Read more »

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Premium RRBS Kit
Modulation of Gene Silencing by Cdc7p via H4 K16 Acetylation and Ph...
Published: April, 2019

Abstract: CAF-1 is an evolutionarily conserved H3/H4 histone chaperone that plays a key role in replication-coupled chromatin assembly and is targeted to the... Read more »

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Antibody
Kdm6b regulates context-dependent hematopoietic stem cell self-rene...
Published: April, 2019

Abstract: The histone demethylase KDM6B (JMJD3) is upregulated in blood disorders, suggesting that it may have important pathogenic functions. Here we examin... Read more »

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Antibody
Hominoid-Specific Transposable Elements and KZFPs Facilitate Human ...
Published: March, 2019

Abstract: Expansion of transposable elements (TEs) coincides with evolutionary shifts in gene expression. TEs frequently harbor binding sites for transcripti... Read more »

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Antibody

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