Diagenode

抗体

ヒストン抗体

ヒストンは、クロマチンの主なタンパク質成分で、基本単位であるヌクレオソームへのDNAの圧縮に関与します。ヌクレオソームは、146塩基対のDNAで包まれた八量体構造を形成するコアヒストン(H2A、H2B、H3およびH4)の各々の1対からなります。 異また、リンカーヒストンH1によって連結され、クロマチンのさらなる縮合を可能にします。

球状構造をしているコアヒストンには、ヌクレオソームから突出している構造化されていない、大型のN末端テールがあります。 それらは、主にN末端の尾部で複数の翻訳後修飾(PTM)を受けることができます。 これらの翻訳後修飾には、メチル化、アセチル化、リン酸化、ユビキチン化、シトルリン化、SUMO化、脱アミノ化およびクロトニル化が含まれます。 最もよく特徴付けられたPTMはメチル化、アセチル化およびリン酸化です。 ヒストンのメチル化は、モノメチル‐ジまたはトリメチル化され得るリジン(K)残基、およびモノメチル化され、対称または非対称にジメチル化され得るアルギニン(R)上で主に生じます。 ヒストンアセチル化は、主にセリン(S)、トレオニン(T)およびチロシン(Y)に基づくリジンおよびヒストンのリン酸化に起こります。

異なる残基のPTMは、DNA修復、DNA複製および染色体凝縮などの多数のプロセスに関与します。それらはクロマチン組織化に影響を及ぼし、遺伝子発現に対し、正または負に関連し得ます。 H3K4、H3K36およびH3K79のトリメチル化、ならびにリジンアセチル化は、一般に、開いたクロマチン配置(以下の図)をもたらし、それにより真正細菌および遺伝子活性化に関連します。 一方、H3K9、K3K27およびH4K20のトリメチル化は、ヘテロクロマチンが豊富であることから、遺伝子サイレンシングに関連します。 異なるヒストン修飾の組み合わせは、遺伝子コードと同様に、「ヒストンコード」と呼ばれます。

Diagenodeは、ヒストンやヒストン修飾に必須である抗体を幅広く提供します。当社の抗体は非常に特異的であり、ChIPおよびChIP-seqを含む多くの研究で有効性が確認されています。

Diagenodeの製品には、以下を認識する抗体が含まれます:

  • ヒストンH1変異体

  • ヒストンH2A、H2A変異体およびヒストンH2A修飾(セリンリン酸化、リジンアセチル化、リジンユビキチン化)

  • ヒストンH2BおよびH2B修飾(セリンリン酸化、リジンアセチル化)
  • ヒストンH3およびH3修飾(リジンメチル化(モノ、ジおよびトリメチル化)、リジンアセチル化、セリンリン酸化、スレオニンリン酸化、アルギニンメチル化(モノメチル化、対称および非対称ジメチル化))

  • ヒストンH4およびH4修飾(リジンメチル化(モノ - 、ジ - およびトリ - メチル化)、リジンアセチル化、アルギニンメチル化(モノメチル化および対称性ジメチル化)、セリンリン酸化)

ヒストンを修飾するHDACのHAT、HMTおよび他の酵素は、ヒストン修飾酵素のカテゴリーをごをご覧ください。

Diagenodeの高度検証された抗体:

  •         高感度で特異的
  •         優れたコストパフォーマンス(1反応につき必要な抗体が少量)
  •         ウェブで入手可能なバッチ固有データ
  •         専門技術サポート
  •         便利なサンプルサイズも購入可
  •         100%満足保証

製品

Cat. No.Product実験手法純度
C15310224 H1.0 Antibody
(100 µl)
ELISA Whole antiserum
C15310249 H1.1 Antibody
(100 µl)
ELISA Whole antiserum
C15310226 H1.3 Antibody
(100 µl)
ELISA Whole antiserum
C15310227 H1.4 Antibody
(100 µl)
ELISA Whole antiserum
C15310228 H1.5 Antibody
(100 µl)
ELISA Whole antiserum
C15210002 H2A.X Antibody
(100 µg /100 µl)
ChIP-qPCR IF WB Protein A purified
C15410219 H2A.XS139p Antibody
(50 μg/ 19 μl)
DB ELISA IF WB Affinity purified
C15310223 H2A.XS139p Antibody
(100 µl)
ELISA Whole antiserum
C15410201 H2A.Z Antibody
(50 μg)
ChIP-qPCR ChIP-seq CUT&Tag ELISA IF WB Affinity purified
C15210021 H2A.Z Antibody
(100 µg)
ChIP-seq IF WB Affinity purified polyclonal antibody
C15410173 H2A.Zac Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA IF Affinity purified
C15410202-50 H2A.Zac Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA IF WB Affinity purified
C15210009 H2A.ZK4ac Antibody
(100 µg)
ChIP-qPCR ChIP-seq IF WB Protein A purified monoclonal antibody in PBS containing 50% glycerol, 1% BSA and 0.09% azide.
C15210012 H2A.ZK7ac Antibody
(100 μg)
ChIP-qPCR ChIP-seq IF WB Protein A purified monoclonal antibody in PBS containing 50% glycerol, 1% BSA and 0.09% azide.
C15410002 H2AK119ub Antibody
(50 μg/46 μl)
ChIP-qPCR DB ELISA WB Affinity purified
C15410215 H2AK5ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA IF WB Affinity purified
C15410166 H2Apan Antibody
(50 μg)
ChIP-qPCR ELISA IF WB Affinity purified
C15410212 H2BK12ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA IF WB Affinity purified
C15410220 H2BK15ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA IF WB Affinity purified
C15210010 H2BK20ac Antibody
(100 µg)
ChIP-qPCR ChIP-seq IF WB Protein A purified monoclonal antibody in PBS containing 50% glycerol, 1% BSA and 0.09% azide.
C15410157 H2Bpan Antibody
(50 μg/18 μl)
ChIP-qPCR ELISA WB Peptide affinity purified
C15200186 H2Bs14p Antibody
(50 μg/50 μl)
DB ELISA Protein A purified
C15210011 H3.3 Antibody
(100 µg)
ChIP-qPCR ChIP-seq WB Protein A purified monoclonal antibody in PBS containing 50% glycerol, 1% BSA and 0.09% azide.
C15410310 H3K14ac Antibody
(50 μg)
ChIP-qPCR DB ELISA WB Affinity purified
C15210005 H3K14ac Antibody
(100 µg)
ChIP-qPCR ChIP-seq DB IF WB Protein A purified monoclonal antibody in PBS containing 1% BSA and 0.09% azide.
C15410139 H3K18ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq CUT&Tag DB ELISA IF WB Affinity purified
C15210020 H3K18ac Antibody
(100 µg)
ChIP-qPCR ChIP-seq DB IF WB Affinity purified monoclonal antibody
C15410290 H3K18me1 Antibody
(50 μg)
ChIP-qPCR DB IF WB Affinity purified
C15410291 H3K18me2 Antibody
(50 μg)
ChIP-qPCR DB IF WB Affinity purified
C15410292 H3K18me3 Antibody
(50 μg)
ChIP-qPCR DB IC IF WB Affinity purified
C15410344 H3K23ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA WB Affinity purified polyclonal antibody in PBS containing 0.05% azide.
C15210007 H3K23me2 Antibody
(100 µg)
ChIP-qPCR ChIP-seq WB Protein A purified monoclonal antibody in PBS containing 50% glycerol, 1% BSA and 0.09% azide.
C15200184-50 H3K27ac Antibody
(50 μg)
ChIP-qPCR CUT&Tag ELISA IF WB Protein A purified
C15410174 H3K27ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA IF WB Affinity purified polyclonal antibody.
C15410196 H3K27ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq CUT&Tag DB ELISA IF WB Affinity purified
C15210016 H3K27ac Antibody
(100 µg)
ChIP-qPCR DB IF WB Affinity purified polyclonal antibody.
C15410045-50 H3K27me1 Antibody
(50 µg)
ChIP-qPCR DB ELISA IF WB Affinity purified polyclonal antibody.
C15410046-50 H3K27me2 Antibody
(50 µg/19 µl)
ChIP-qPCR DB ELISA IF WB Affinity purified
C15200181-50 H3K27me3 Antibody
(50 μg)
ChIP-qPCR CUT&Tag ELISA IF WB Protein A purified monoclonal antibody.
C15410195 H3K27me3 Antibody
(50 μg)
ChIP-qPCR ChIP-seq CUT&Tag DB ELISA IF Peptide array WB Affinity purified polyclonal antibody.
C15410069 H3K27me3 polyclonal antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA IF WB Affinity purified polyclonal antibody.
C15310091 H3K27me3S28p Antibody
(100 µl)
ChIP-qPCR DB ELISA IF IP WB Whole antiserum
C15410293 H3K27me3S28p Antibody
(50 μg)
ChIP-qPCR DB IF WB Affinity purified
C15410091 H3K27me3S28p Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA WB Affinity purified
C15410307 H3K36ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA WB Affinity purified
C15410089 H3K36me1 Antibody
(50 µg/54 µl)
ChIP-qPCR DB ELISA WB Affinity purified
C15200182 H3K36me2 Antibody
(50 μg/50 μl)
ChIP-qPCR DB ELISA WB Protein A purified monoclonal antibody.
C15310127 H3K36me2 Antibody
(100 µl)
ChIP-qPCR ChIP-seq CUT&Tag DB ELISA IF WB Whole antiserum from rabbit.
C15200183 H3K36me3 Antibody
(50 μg/50 μl)
ChIP-qPCR DB ELISA IF WB Protein A purified
C15310058 H3K36me3 Antibody
(100 µl)
ChIP-qPCR ChIP-seq DB ELISA WB Whole antiserum from rabbit containing 0.05% azide.
C15410058 H3K36me3 Antibody
(50 µg)
ChIP-qPCR ChIP-seq DB ELISA WB Affinity purified
C15410192 H3K36me3 Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA IF WB Affinity purified polyclonal antibody.
C15210013 H3K36me3 Antibody
(100 µg)
ChIP-qPCR ChIP-seq DB WB Affinity purified polyclonal antibody.
C15410295 H3K37me1 Antibody
(50 μg)
DB WB Affinity purified
C15410322 H3K4ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA WB Affinity purified polyclonal antibody
C15410165 H3K4ac Antibody - replaced by the reference C15410322
(50 μg/34 μl)
ChIP-qPCR DB ELISA IF WB Affinity purified
C15200150 H3K4me1 Antibody
(50 µg/50 µl)
ChIP-qPCR ELISA IF WB Protein A purified
C15310037 H3K4me1 Antibody
(100 µl)
ChIP-qPCR DB ELISA WB Whole antiserum
C15410037-50 H3K4me1 Antibody
(50 µg)
ChIP-qPCR ChIP-seq DB ELISA WB Affinity purified polyclonal antibody.
C15410194 H3K4me1 Antibody
(50 μg)
ChIP-qPCR ChIP-seq CUT&Tag DB ELISA IF Peptide array WB Affinity purified polyclonal antibody.
C15210018 H3K4me1 Antibody
(100 µg)
ChIP-qPCR ChIP-seq DB IF WB Affinity purified polyclonal antibody.
C15410280 H3K4me1T6p Antibody
(50 μg)
DB IF IHC WB Affinity purified
C15200151 H3K4me2 Antibody
(50 µg/50 µl)
ChIP-qPCR ELISA IF WB Protein A purified
C15310035 H3K4me2 Antibody
(100 µl)
ChIP-qPCR DB ELISA WB Whole antiserum
C15410035 H3K4me2 Antibody
(50 μg)
ChIP-qPCR ChIP-seq CUT&Tag DB ELISA IF WB Affinity purified polyclonal antibody.
C15200152 H3K4me3 Antibody
(50 µg)
ChIP-qPCR ChIP-seq CUT&Tag ELISA IF WB Protein A purified monoclonal antibody.
C15410030 H3K4me3 Antibody
(50 µg)
ChIP-qPCR ChIP-seq DB IF WB Affinity purified polyclonal antibody.
C15310003 H3K4me3 Antibody
(100 µl)
ChIP-qPCR DB ELISA WB Whole antiserum
C15410003-50 H3K4me3 polyclonal antibody
(50 µg)
ChIP-qPCR ChIP-seq CUT&Tag DB ELISA IF WB Affinity purified polyclonal antibody.
C15410281 H3K4me3T6p Antibody
(50 μg)
ChIP-qPCR DB IF IHC WB Affinity purified
C15200149 H3K4un Antibody
(50 µg/50 µl)
ChIP-qPCR ELISA IF WB Protein A purified
C15410213 H3K56ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq CUT&Tag ELISA WB Affinity purified
C15410296 H3K56me1 Antibody
(50 μg)
ChIP-qPCR DB IF WB Affinity purified
C15410297 H3K56me3 Antibody
(50 μg)
DB IF WB Affinity purified
C15410211 H3K64me3 Antibody
(50 μg)
ChIP-qPCR DB ELISA WB Affinity purified
C15210006 H3K79ac Antibody
(100 µg)
ChIP-qPCR ChIP-seq IF WB Protein A purified
C15310082 H3K79me1 Antibody
(100 µl)
ChIP-qPCR DB ELISA WB Whole antiserum
C15410082 H3K79me1 Antibody
(50 μg)
ChIP-qPCR ChIP-seq CUT&Tag DB ELISA WB Affinity purified
C15310051 H3K79me2 Antibody
(100 µl)
ChIP-qPCR DB ELISA WB Whole antiserum
C15410051 H3K79me2 Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA IF WB Affinity purified
C15310068 H3K79me3 Antibody
(100 µl)
DB ELISA IF WB Whole antiserum
C15410068 H3K79me3 Antibody
(50 µg)
ChIP-qPCR ChIP-seq DB ELISA WB Affinity purified polyclonal antibody
C15410005 H3K9/14ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA IF WB Affinity purified
C15410200 H3K9/14ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq CUT&Tag DB ELISA IF Peptide array WB Affinity purified polyclonal antibody.
C15200185-50 H3K9ac Antibody
(50 μg/50 μl)
ChIP-qPCR ELISA IF WB Protein A purified monoclonal antibody
C15410004 H3K9ac Antibody
(50 µg)
ChIP-qPCR ChIP-seq DB ELISA IF WB Affinity purified
C15410177 H3K9ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA WB Affinity purified
C15210015 H3K9ac Antibody
(100 µg)
ChIP-qPCR ChIP-seq DB WB Affinity purified polyclonal antibody.
C15310102 H3K9acS10p Antibody
(100 µl)
ChIP-qPCR DB ELISA IF WB Whole antiserum
C15310065 H3K9me1 Antibody
(100 µl)
ChIP-qPCR DB ELISA IF WB Whole antiserum
C15410065 H3K9me1 Antibody
(50 µg/43 µl)
ChIP-qPCR DB ELISA WB Affinity purified
C15200154 H3K9me2 Antibody
(50 μg)
ChIP-qPCR ELISA IF WB Protein A purified monoclonal antibody.
C15410060 H3K9me2 Antibody
(50 µg/44 µl)
ChIP-qPCR DB ELISA IF WB Affinity purified polyclonal antibody
C15210019 H3K9me2 Antibody
(100 µg/ 100 µl)
ChIP-qPCR ChIP-seq IF WB Affinity purified monoclonal antibody
C15200146 H3K9me3 Antibody
(50 μg)
ChIP-qPCR CUT&Tag DB IF WB Protein A purified
C15410013 H3K9me3 Antibody
(50 µg/39 µl)
WB Protein G purified
C15100146 H3K9me3 Antibody
(100 µl)
ChIP-qPCR DB WB Concentrated supernatant
C15410056 H3K9me3 Antibody
(50 µg)
ChIP-qPCR ChIP-seq DB ELISA WB Affinity purified polyclonal antibody.
C15310013 H3K9me3 Antibody
(100 µl)
ChIP-qPCR WB Whole antiserum
C15410193 H3K9me3 Antibody
(50 μg)
ChIP-qPCR ChIP-seq CUT&Tag DB ELISA IF WB Affinity purified polyclonal antibody.
C15210014 H3K9me3 Antibody
(100 µg)
ChIP-qPCR ChIP-seq WB Affinity purified polyclonal antibody.
C15200153 H3K9me3 Antibody
(50 µg/50 µl)
ChIP-qPCR ELISA IF WB Protein A purified
C15500003-50 H3K9me3 recombinant antibody and negative control
(50 µg)
ChIP-qPCR ChIP-seq IF affinity purified
C15310128 H3K9me3S10p Antibody
(100 µl)
ChIP-qPCR DB ELISA IF WB Whole antiserum
C15200187 H3K9un Antibody
(50 μg/25 μl)
ChIP-qPCR IF WB Protein A purified
C15310135 H3pan Antibody
(100 µl)
ChIP-qPCR ELISA WB Whole antiserum
C15410324-50 H3pan Antibody
(50 μg/16 μl)
ChIP-qPCR ELISA IF WB Affinity purified
C15200011 H3pan Antibody 1B1B2
(50 μg)
ChIP-qPCR IF WB Protein A purified monoclonal antibody.
C15310092 H3R17me2(asym) Antibody
(100 µl)
ChIP-qPCR DB ELISA WB Whole antiserum
C15410289 H3R17me2(asym) Antibody
(50 μg)
ChIP-qPCR IF WB Affinity purified
C15410171 H3R17me2(asym)K18ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA IF WB Affinity purified
C15410276 H3R2me1 Antibody
(50 μg)
WB Affinity purified
C15410294 H3R2me2K4me2 Antibody
(50 μg)
ChIP-qPCR DB IF WB Affinity purified
C15410303 H3R2me2sT3p Antibody
(50 μg)
DB IF WB Affinity purified
C15410286 H3R8me2(asym) Antibody
(50 μg)
ChIP-qPCR IF IHC WB Affinity purified
C15410287 H3R8me2(sym) Antibody
(50 μg)
ChIP-qPCR WB Affinity purified
C15310116 H3S10p Antibody
(100 µl)
ChIP-qPCR DB ELISA IF IP WB Whole antiserum
C15410116-50 H3S10p Antibody
(50 μg/48 μl)
ChIP-qPCR DB ELISA IF WB Affinity purified
C15410288 H3S10pT11p Antibody
(50 μg)
ChIP-qPCR IF IHC WB Affinity purified
C15410309 H3T11p Antibody
(50 μg)
ChIP-qPCR DB ELISA IF WB Affinity purified
C15210001 H3T3p Antibody
(100 μg/100 μl)
ChIP-qPCR IF WB Protein A purified
C15410279 H3T3pK4ac Antibody
(50 μg)
DB IF IHC WB Affinity purified
C15410277 H3T3pK4me1 Antibody
(50 μg)
DB IF IHC WB Affinity purified
C15410278 H3T3pK4me2 Antibody
(50 μg)
ChIP-qPCR DB IF IHC WB Affinity purified
C15410321 H3T45p Antibody
(50 μg /34 μl)
DB ELISA Affinity purified
C15410282 H3T6p Antibody
(50 μg)
DB IF IHC WB Affinity purified
C15410283 H3T6pK9me1 Antibody
(50 μg)
ChIP-qPCR DB IF IHC WB Affinity purified
C15410284 H3T6pK9me2 Antibody
(50 μg)
ChIP-qPCR IF IHC WB Affinity purified
C15410285 H3T6pK9me3 Antibody
(50 μg)
ChIP-qPCR DB IF IHC WB Affinity purified
C15410302 H4K12ac Antibody
(50 μg)
DB IF IHC WB Affinity purified
C15200218 H4K12ac Antibody
(50 µg)
ChIP-qPCR DB WB Protein A purified
C15410331-50 H4K12ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA IF WB Affinity purified
C15200219 H4K16ac Antibody
(50 µg)
ChIP-qPCR DB WB Protein A purified
C15410300 H4K16ac Antibody
(50 μg)
DB IF WB Affinity purified
C15210008 H4K20ac Antibody
(100 µg)
ChIP-qPCR ChIP-seq IF WB Protein A purified monoclonal antibody in PBS containing 50% glycerol, 1% BSA and 0.09% azide.
C15200147 H4K20me1 Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB IF WB Protein A purified
C15310034 H4K20me1 Antibody
(100 µl)
ChIP-qPCR DB ELISA WB Whole antiserum
C15410034 H4K20me1 Antibody
(50 μg/25 μl)
ChIP-qPCR DB ELISA IF WB Affinity purified
C15100147 H4K20me1 Antibody
(100 µl)
ChIP-qPCR DB WB Concentrated supernatant
C15200205 H4K20me2 Antibody
(100 µl)
ChIP-qPCR IC IF WB Protein G purified
C15200220 H4K20me2 Antibody
(50 µg)
ChIP-qPCR DB IF WB Protein A purified
C15410301 H4K20me2 Antibody
(50 μg)
ChIP-qPCR IF WB Affinity purified
C15410057 H4K20me3 Antibody
(50 μg)
ChIP-qPCR ChIP-seq CUT&Tag DB ELISA IF WB Affinity purified
C15410207 H4K20me3 Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB ELISA IF Peptide array WB Affinity purified polyclonal antibody.
C15410024 H4K5,8,12,16ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq DB IF Affinity purified polyclonal antibody.
C15410021 H4K5,8,12ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq CUT&Tag DB ELISA IF WB Affinity purified
C15410025 H4K5ac Antibody
(50 μg)
ChIP-qPCR ChIP-seq CUT&Tag DB ELISA IF WB Affinity purified
C15200217 H4K8ac Antibody
(50 µg)
ChIP-qPCR DB WB Protein A purified
C15310103 H4K8ac Antibody
(100 µl)
ChIP-qPCR DB ELISA WB Whole antiserum
C15410103 H4K8ac Antibody
(50 μg/41 μl)
ChIP-qPCR DB ELISA IF WB Affinity purified
C15410156-50 H4pan Antibody
(50 μg/39 μl)
ChIP-qPCR ELISA WB Affinity purified
C15410299 H4R3me1 Antibody
(50 μg)
ChIP-qPCR DB IC IF WB Affinity purified
C15210022 H4R3me1 Antibody
(100 µg)
DB IF WB Affinity purified monoclonal antibody
C15410308 H4R3me2(sym) Antibody
(50 μg)
DB ELISA IF WB Affinity purified
C15410298 H4S1p Antibody
(50 μg)
ChIP-qPCR DB IF IHC WB Affinity purified
C15210004 H4S1p Antibody
(100 µg /100 µl)
ChIP-qPCR IF WB Protein A purified
C15210003 macroH2A.1/H2A.2 Antibody
(100 µg)
ChIP-qPCR ChIP-seq IF WB Protein A purified

イベント

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    New Orleans, Louisiana, USA
    Dec 10-Dec 13, 2022
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