Chromatin studies

Chromatin structure plays a key role in regulating gene expression by allowing DNA accessibility to transcriptional machinery and transcription factors. The packaging of DNA into nucleosomes forms a closed structure that is not highly accessible to transcriptional elements whereas the open nucleosome structure allows DNA to be accessible. Diagenode offers a number of solutions to help you analyze chromatin and the role of transcriptional machinery including ChIP kits, ChIPmentation kits, antibodies, pA-Tn5 and ATAC-seq kits.

Chromatin immunoprecipitation (ChIP) determines the location of DNA binding sites on the genome for a protein of interest, giving insights into gene expression regulation. ChIP involves the selective enrichment of a chromatin fraction containing a specific antigen. Antibodies that recognize a protein or protein modification are used to determine the relative abundance of that antigen at a specific locus or loci. ChIP can be used to compare enrichment of proteins, map protein modifications, or quantify a protein modification during a time course.

The ChIP workflow

Products for chromatin study

Efficient solution for protein-protein fixation. Read more

  Chromatin shearing
Perfectly sheared chromatin is critical for ChIP success. 
Read more about solutions for successful chromatin preparation. 
Read more about Bioruptor sonication.

  Chromatin immunoprecipitation
Immunoprecipitation solutions for histone and transcription factor ChIP-qPCR and ChIP-seq for low inputs, plants, and animals including automated solutionsRead more

ChIPmentation, an exclusive technology, is an end-to-end ChIP-seq solution for low and difficult inputs. Read more

  ChIP and ChIP-seq antibodies
ChIP-grade antibodies are essential for success. Learn more

  Primer pairs
Highly specific primer pairs for the amplification of the specific genomic regions. Read more

  CUT&Tag solutions
An alternative to ChIP-seq that combines antibody-targeted controlled cleavage by a protein A-Tn5 fusion with NGS to identify the binding sites of DNA-associated proteins. Read more

  DNA purification
Read more about solutions for DNA purification

  Library preparation for ChIP-seq
Optimized solutions for the library preparation from low DNA input. Read more

  ChIP and ChIP-seq automation
Reproducibility, optimization simplicity, no variability. Learn more

We offer complete ChIP kits or individual kit components from antibodies, buffers, beads, chromatin shearing, and purification reagents. With the ChIP Kit Customizer, you have complete flexibility on which components you want from our validated ChIP kits.

Chromatin resources


Application notes

Publications related to ChIP



Cat. No.ProductFormatPrice
C01080002 ATAC-seq kit
ATAC-seq, Assay for Transposase-Accessible Chromatin, followed by next generation sequencing, is a key technology for genome-wide mapping of ...
24 rxns $1,745.00

Chromatin shearing

Chromatin immunoprecipitation


Cat. No.ProductFormatPrice
C01011011 µChIPmentation Kit for Histones
The Diagenode µChIPmentation Kit for Histones is optimized to perform ChIP-seq on as little as 10.000 cells from cell fixation to purified libraries....
24 rxns $2,400.00
C01011032 24 SI for Tagmented libraries
The 24 SI for tagmented libraries includes 24 single primer indexes for multiplexing up to 24 samples. The primer indexes of the 24 SI Tagmented libraries ...
24 SI $185.00
C01011033 8 SI for Tagmented libraries
The 8 SI for tagmented libraries includes 8 single primer indexes for multiplexing up to 8 samples. The primer indexes of the 8 SI Tagmented libraries are ...
8 SI $75.00
C01011000 Auto ChIPmentation Kit for Histones - Replaced by C01011009
Contact us This product must be used with the IP-Star Compact Automated System. Diagenode’s latest technology for histone ChIP-seq, ...
24 rxns
C01011010 ChIPmentation Kit for Histones - Replaced by C01011009
Contact us Difficult and challenging histone ChIP-seq is now solved. Diagenode’s latest technology for histone ChIP-seq, ChIPmentation ...
24 rxns
C01011030 TAG Kit for ChIPmentation
Contact us Tagmentation is a reaction where an enzyme (a transposase) cleaves DNA and incorporates sequencing adaptors at the ends of the DNA fra...
24 rxns $1,050.00


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    Antibody package for CUT&Tag (anti-mouse)
  • default alt
    Antibody package for CUT&Tag (anti-rabbit)
  • default alt
    iDeal CUT&Tag kit for Histones Compatible wit...
  • default alt
    pA-Tn5 Transposase - loaded
  • default alt
    pA-Tn5 Transposase - unloaded
  • Mouse IgG
    Rabbit IgG



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