Chromatin immunoprecipitation (ChIP) is a method used to determine the location of genome binding sites for a specific protein of interest, giving invaluable insights into the regulation of gene expression. ChIP involved the selective enrichment of a chromatin fraction containing a specific antigen. Antibodies that recognize a specific protein or protein modification are used to determine the relative abundance of the antigen at specific loci. ChIP-seq and ChIP-qPCR are techniques that allow the identification of protein-DNA binding sites.
The ChIP workflow
Products for chromatin study
Efficient solution for protein-protein fixation. Read more
Perfectly sheared chromatin is critical for ChIP success.
Read more about reagent optimization.
Read more about Bioruptor sonication.
Immunoprecipitation solutions for histone and transcription factor ChIP-qPCR and ChIP-seq for low inputs, plants, and animals including automated solutions. Read more
ChIPmentation, an exclusive technology, is an end-to-end ChIP-seq solution for low and difficult inputs. Read more
ChIP and ChIP-seq antibodies
ChIP-grade antibodies are essential for success. Learn more
Highly specific primer pairs for the amplification of the specific genomic regions. Read more
Read more about solutions for DNA purification
Library preparation for ChIP-seq
Optimized solutions for the library preparation from low DNA input. Read more
ChIP and ChIP-seq automation
Reproducibility, optimization simplicity, no variability. Learn more
Chromatin assembly products
Study the nucleosome environment. Learn more
Publications related to ChIP