Diagenode
| United States | My cart | Login / Sign-up Search

Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1425 publications found×
Balance between autophagy and cell death is maintained byPolycomb-mediated regulation during stem cell differentiation.
Published: November, 2022
Abstract: Autophagy is a conserved cytoprotective process, aberrations in which lead to numerous degenerative disorders. While the cytoplasmic components of autophagy have been extensively studied, the epigenetic regulation of autophagy genes, especially in...
Read more »
Tags
Bioruptor Antibody
Estrone, the major postmenopausal estrogen, binds ERa to induceSNAI2, epithelial-to-mesenchymal transition, and ER+ breast cancermetastasis.
Published: November, 2022
Abstract: Recent work showed that the dominant post-menopausal estrogen, estrone, cooperates with nuclear factor κB (NF-κB) to stimulate inflammation, while pre-menopausal 17β-estradiol opposes NF-κB. Here, we show that post-menopausa...
Read more »
Tags
Antibody
Dietary methionine starvation impairs acute myeloid leukemia progression.
Published: November, 2022
Abstract: Targeting altered tumor cell metabolism might provide an attractive opportunity for patients with acute myeloid leukemia (AML). An amino acid dropout screen on primary leukemic stem cells and progenitor populations revealed a number of amino acid ...
Read more »
Tags
Antibody
Efficacy of selective histone deacetylase 6 inhibition in mouse models ofPseudomonas aeruginosa infection: A new glimpse for reducinginflammation and infection in cystic fibrosis.
Published: October, 2022
Abstract: The latest studies identified the histone deacetylase (HDAC) class of enzymes as strategic components of the complex molecular machinery underlying inflammation in cystic fibrosis (CF). Compelling new support has been provided for HDAC6 isoform as...
Read more »
Tags
Antibody
The telomeric protein TERF2/TRF2 impairs HMGB1-driven autophagy.
Published: October, 2022
Abstract: TERF2/TRF2 is a pleiotropic telomeric protein that plays a crucial role in tumor formation and progression through several telomere-dependent and -independent mechanisms. Here, we uncovered a novel function for this protein in regulating the macro...
Read more »
Tags
Antibody
Systems-biology analysis of rheumatoid arthritis fibroblast-likesynoviocytes implicates cell line-specific transcription factor function.
Published: October, 2022
Abstract: Rheumatoid arthritis (RA) is an immune-mediated disease affecting diarthrodial joints that remains an unmet medical need despite improved therapy. This limitation likely reflects the diversity of pathogenic pathways in RA, with individual patients...
Read more »
Tags
Antibody
Viral transduction of primary human lymphoma B cells reveals mechanismsof NOTCH-mediated immune escape.
Published: October, 2022
Abstract: Hotspot mutations in the PEST-domain of NOTCH1 and NOTCH2 are recurrently identified in B cell malignancies. To address how NOTCH-mutations contribute to a dismal prognosis, we have generated isogenic primary human tumor cells from patients with C...
Read more »
Tags
Antibody
Vitamin C enhances NF-κB-driven epigenomic reprogramming andboosts the immunogenic properties of dendritic cells.
Published: October, 2022
Abstract: Dendritic cells (DCs), the most potent antigen-presenting cells, are necessary for effective activation of naïve T cells. DCs' immunological properties are modulated in response to various stimuli. Active DNA demethylation is crucial for DC d...
Read more »
Tags
Antibody IPure kit
The genome sequence of the satellite, Eupsilia transversa (Hufnagel,1766)
Published: October, 2022
Abstract: We present a genome assembly from an individual female Eupsilia transversa (the satellite; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence is 467 megabases in span. The entire assembly (100\%) is scaffolded into 32 chromosomal ps...
Read more »
Tags
Antibody
The genome sequence of the common yellow swallowtail, Papilio machaon(Linnaeus, 1758)
Published: October, 2022
Abstract: We present a genome assembly from an individual female Papilio machaon (the common yellow swallowtail; Arthropoda; Insecta; Lepidoptera; Papilionidae). The genome sequence is 252 megabases in span. The majority of the assembly (99.97\%) is scaffol...
Read more »
Tags
Antibody
A transition phase in late mouse oogenesis impacts DNA methylation ofthe early embryo.
Published: October, 2022
Abstract: A well-orchestrated program of oocyte growth and differentiation results in a developmentally competent oocyte. In late oogenesis, germinal vesicle oocytes (GVOs) undergo chromatin remodeling accompanied by transcriptional silencing from an NSN (n...
Read more »
Tags
Antibody
Monitoring autochthonous lung tumors induced by somatic CRISPR geneediting in mice using a secreted luciferase.
Published: October, 2022
Abstract: BACKGROUND: In vivo gene editing of somatic cells with CRISPR nucleases has facilitated the generation of autochthonous mouse tumors, which are initiated by genetic alterations relevant to the human disease and progress along a natural timeline as...
Read more »
Tags
Antibody CRISPR
Trained Immunity Provides Long-Term Protection againstBacterial Infections in Channel Catfish.
Published: October, 2022
Abstract: Beta glucan exposure induced trained immunity in channel catfish that conferred long-term protection against and infections one month post exposure. Flow cytometric analyses demonstrated that isolated macrophages and neutrophils phagocytosed highe...
Read more »
Tags
Antibody
Linked-read whole-genome sequencing resolves common and privatestructural variants in multiple myeloma.
Published: September, 2022
Abstract: Multiple myeloma (MM) is an incurable and aggressive plasma cell malignancy characterized by a complex karyotype with multiple structural variants (SVs) and copy-number variations (CNVs). Linked-read whole-genome sequencing (lrWGS) allows for refi...
Read more »
Tags
Antibody
Repression and 3D-restructuring resolves regulatory conflicts inevolutionarily rearranged genomes.
Published: September, 2022
Abstract: Regulatory landscapes drive complex developmental gene expression, but it remains unclear how their integrity is maintained when incorporating novel genes and functions during evolution. Here, we investigated how a placental mammal-specific gene, ...
Read more »
Tags
Antibody iDeal ChIP-seq Kit for Histones
Exploration of nuclear body-enhanced sumoylation reveals that PMLrepresses 2-cell features of embryonic stem cells.
Published: September, 2022
Abstract: Membrane-less organelles are condensates formed by phase separation whose functions often remain enigmatic. Upon oxidative stress, PML scaffolds Nuclear Bodies (NBs) to regulate senescence or metabolic adaptation. PML NBs recruit many partner prot...
Read more »
Tags
Bioruptor Antibody iDeal ChIP-qPCR
Dominant role of DNA methylation over H3K9me3 for IAP silencingin endoderm.
Published: September, 2022
Abstract: Silencing of endogenous retroviruses (ERVs) is largely mediated by repressive chromatin modifications H3K9me3 and DNA methylation. On ERVs, these modifications are mainly deposited by the histone methyltransferase Setdb1 and by the maintenance DNA...
Read more »
Tags
Antibody Microplex Library Preparation kit
A complex epigenome-splicing crosstalk governs epithelial-to-mesenchymaltransition in metastasis and brain development.
Published: August, 2022
Abstract: Epithelial-to-mesenchymal transition (EMT) renders epithelial cells migratory properties. While epigenetic and splicing changes have been implicated in EMT, the mechanisms governing their crosstalk remain poorly understood. Here we discovered that...
Read more »
Tags
Bioruptor Antibody
Vitamin D receptor and STAT6 interactome governs oesophagealepithelial barrier responses to IL-13 signalling.
Published: August, 2022
Abstract: OBJECTIVE: The contribution of vitamin D (VD) deficiency to the pathogenesis of allergic diseases remains elusive. We aimed to define the impact of VD on oesophageal allergic inflammation. DESIGN: We assessed the genomic distribution and function ...
Read more »
Tags
Antibody IP-Star Compact
Histone demethylase KDM2A suppresses EGF-TSPAN8 pathway toinhibit breast cancer cell migration and invasion in vitro.
Published: August, 2022
Abstract: Metastasis is a major cause of breast cancer mortality and the current study found histone demethylase, KDM2A, expression to be negatively correlated with breast cancer metastasis. KDM2A knockdown greatly promoted migration and invasion of breast ...
Read more »
Tags
Antibody
Distinct silencer states generate epigenetic states of heterochromatin.
Published: August, 2022
Abstract: Heterochromatic loci can exhibit different transcriptional states in genetically identical cells. A popular model posits that the inheritance of modified histones is sufficient for inheritance of the silenced state. However, silencing inheritance ...
Read more »
Tags
Antibody
bESCs from cloned embryos do not retain transcriptomic or epigenetic memory from somatic donor cells.
Published: August, 2022
Abstract: Embryonic stem cells (ESC) indefinitely maintain the pluripotent state of the blastocyst epiblast. Stem cells are invaluable for studying development and lineage commitment, and in livestock they constitute a useful tool for genomic improvement an...
Read more »
Tags
Antibody
Histone lysine demethylase inhibition reprograms prostate cancermetabolism and mechanics.
Published: August, 2022
Abstract: OBJECTIVE: Aberrant activity of androgen receptor (AR) is the primary cause underlying development and progression of prostate cancer (PCa) and castration-resistant PCa (CRPC). Androgen signaling regulates gene transcription and lipid metabolism, ...
Read more »
Tags
Antibody Bioruptor Plus
The Arabidopsis APOLO and human UPAT sequence-unrelated longnoncoding RNAs can modulate DNA and histone methylation machineries inplants.
Published: August, 2022
Abstract: BACKGROUND: RNA-DNA hybrid (R-loop)-associated long noncoding RNAs (lncRNAs), including the Arabidopsis lncRNA AUXIN-REGULATED PROMOTER LOOP (APOLO), are emerging as important regulators of three-dimensional chromatin conformation and gene transcr...
Read more »
Tags
Bioruptor Antibody
Histone H3K36me2 and H3K36me3 form a chromatin platform essentialfor DNMT3A-dependent DNA methylation in mouse oocytes.
Published: August, 2022
Abstract: Establishment of the DNA methylation landscape of mammalian oocytes, mediated by the DNMT3A-DNMT3L complex, is crucial for reproduction and development. In mouse oocytes, high levels of DNA methylation occur exclusively in the transcriptionally ac...
Read more »
Tags
Antibody
Epigenetic remodeling of downstream enhancer regions is linked toselective expression of the IL1F10 gene in differentiated humankeratinocytes.
Published: August, 2022
Abstract: Interleukin (IL)-38, encoded by the IL1F10 gene, is a member of the IL-1 family of cytokines. IL-38 is constitutively expressed in epithelia in healthy humans, and in particular in epidermal keratinocytes in the skin. IL-38 expression is closely c...
Read more »
Tags
Antibody iDeal ChIP-qPCR
Prolonged FOS activity disrupts a global myogenic transcriptionalprogram by altering 3D chromatin architecture in primary muscleprogenitor cells.
Published: August, 2022
Abstract: BACKGROUND: The AP-1 transcription factor, FBJ osteosarcoma oncogene (FOS), is induced in adult muscle satellite cells (SCs) within hours following muscle damage and is required for effective stem cell activation and muscle repair. However, why FO...
Read more »
Tags
Bioruptor Antibody iDeal ChIP-qPCR
Large-scale manipulation of promoter DNA methylation revealscontext-specific transcriptional responses and stability.
Published: July, 2022
Abstract: BACKGROUND: Cytosine DNA methylation is widely described as a transcriptional repressive mark with the capacity to silence promoters. Epigenome engineering techniques enable direct testing of the effect of induced DNA methylation on endogenous pro...
Read more »
Tags
Antibody
HOTAIR interacts with PRC2 complex regulating the regional preadipocytetranscriptome and human fat distribution.
Published: July, 2022
Abstract: Mechanisms governing regional human adipose tissue (AT) development remain undefined. Here, we show that the long non-coding RNA HOTAIR (HOX transcript antisense RNA) is exclusively expressed in gluteofemoral AT, where it is essential for adipocyt...
Read more »
Tags
Antibody
Embryonic heat conditioning in chicks induces transgenerationalheat/immunological resilience via methylation on regulatory elements.
Published: July, 2022
Abstract: The question of whether behavioral traits are heritable is under debate. An obstacle in demonstrating transgenerational inheritance in mammals originates from the maternal environment's effect on offspring phenotype. Here, we used in ovo embryonic...
Read more »
Tags
Antibody

Events

  • London Calling 2024
    London, UK
    May 21-May 24, 2024
  • Symposium of the Young Scientist Association
    Vienna, Austria
    May 28-May 29, 2024
  • ESHG 2024
    Berlin, Germany
    Jun 1-Jun 4, 2024
  • CLEPIC 2024
    Warsaw, Poland
    Jun 5-Jun 7, 2024
  • EACR 2024
    Rotterdam, Netherlands
    Jun 10-Jun 13, 2024
  • Chromatin meets South 2024
    Marseille, France
    Jun 13-Jun 14, 2024
 See all events

 

       Site map   |   Contact us   |   Conditions of sales   |   Conditions of purchase   |   Privacy policy   |   Diagenode Diagnostics