Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1524 publications found×

Stage-specific epigenetic priming amplifies gene activation during lineage commitment
Published: March, 2026

Abstract: Neural progenitor cells exhibit developmental plasticity as they can commit to distinct developmental trajectories. The male-specific lethal complex (MSLc) is linked to multiple developmental disorders, suggesting a role in neural fate commitm...
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Antibody iDeal ChIP-seq Kit for Histones

Epithelial sensing of vitamin A shapes intestinal antimicrobial defense
Published: March, 2026

Abstract: Vitamin A is a central regulator of intestinal adaptive immunity, but its role in innate immunity is less defined. Antimicrobial proteins form a chemical barrier that protects the intestinal epithelium from microbial invasion. Among these, REG3 fa...
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Antibody iDeal ChIP-seq Kit for Transcription Factors

Hypoxic stress granules trigger immunogenic dormancy in lung cancer
Published: February, 2026

Abstract: Induction of the MHC class I antigen processing and presentation pathway (C1APP) is a critical part of the IFN-γ response necessary for effective cytotoxic immunity against tumors of epithelial origin1,2. Loss of this response is associate...
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Antibody

Comparative multi-omics of the macrophage response to infection with Mycobacterium tuberculosis complex bacteria reveals pathogen-driven epigenomic reprogramming
Published: February, 2026

Abstract: Background Bovine tuberculosis (bTB) is a chronic infectious disease primarily caused by Mycobacterium bovis, which inflicts significant economic losses on the global livestock industry worldwide and can also cause tuberculosis (TB) di...
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Antibody iDeal ChIP-seq Kit for Transcription Factors Chromatin Profiling (ChIP-seq) Services

Microglia-Derived Extracellular Vesicles from Alzheimer's Disease Patients Carry miRNAs Driving a Neuroinflammatory Response
Published: February, 2026

Abstract: Alzheimer's disease (AD) represents the most common cause of dementia and urgently requires sensitive biomarkers and effective therapies. Extracellular vesicles represent membranous nano-sized particles secreted from cells, which serve as interc...
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D-Plex small RNA-seq

Multimodal epigenetic and enhancer network remodeling shape the transcriptional landscape of human beige adipocytes
Published: January, 2026

Abstract: Epigenetic regulation is a key determinant of adipocyte fate, driving the differentiation toward white or thermogenic beige phenotypes in response to environmental cues. To dissect the mechanisms orchestrating this plasticity in human adipocyt...
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Antibody Microplex Library Preparation kit

Multimodal epigenetic and enhancer network remodeling shape the transcriptional landscape of human beige adipocytes
Published: January, 2026

Abstract: Abstract Epigenetic regulation is a key determinant of adipocyte fate, driving the differentiation toward white or thermogenic beige phenotypes in response to environmental cues. To dissect the mechanisms orchestrating this plasticity in human ad...
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Antibody Microplex Library Preparation kit

CRISPR-based precise methylation of specific FUT8 promoter regions allows isolation of CHO cells with a fine-tuned glycoprofile
Published: January, 2026

Abstract: A major advantage of producing therapeutic proteins in mammalian cells is their ability to tailor proteins with human-like posttranslational modifications such as glycosylation, which ultimately defines aspects like stability, protein folding or...
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Antibody iDeal ChIP-seq Kit for Histones

Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptopathy in encephalitis
Published: December, 2025

Abstract: In infectious and autoimmune disorders of the central nervous system, neurons can become cognate immunological targets of cytotoxic T cells, leading to persistent functional and synaptic impairments. However, the molecular underpinnings of such ...
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Antibody True MicroChIP kit ChIPmentation

Antibody-mediated control of anellovirus infection: evidence from people who inject drugs
Published: December, 2025

Abstract: Infections with viruses belonging to the family Anelloviridae are widespread among humans. Although generally considered a commensal, there is evidence to suggest that these infections may be controlled by host immune responses. However,...
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Bioruptor

Refeeding with different levels of dietary carbohydrate modulates epigenetic stability through global DNA (de)methylation and histone modifications in juvenile and adult Nile tilapia (Oreochromis niloticus)
Published: December, 2025

Abstract: The Nile tilapia (Oreochromis niloticus) exhibits a strong metabolic response to dietary carbohydrates (CHO). Short-term refeeding after fasting with a high-carbohydrate (HC) diet has been shown to modulate CHO metabolism, but the role of epigen...
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Antibody

Conserved heat shock factors HvHSFA2 and HvHSFA3 control barley heat stress memory through diverged mechanisms
Published: November, 2025

Abstract: Climate change requires optimizing stress responses in crops. Priming and memory of heat stress (HS) allow plants to improve their tolerance against high temperatures. Here, we investigate HS memory in cultivated barley (Hordeum vulgare) to as...
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Antibody

PRC1-mediated H2A.Zub promotes gene expression by preventing H3.1K27me1 incorporation in Arabidopsis
Published: November, 2025

Abstract: Background: PcG complexes are pivotal in orchestrating the transition from embryonic to vegetative development in plants. However, the mechanisms underlying the gene expression reprogramming that takes place during this developmental transiti...
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Antibody

Epstein-Barr virus-transformed B-cells from a hypoxia model of the germinal center requires external unsaturated fatty acids
Published: November, 2025

Abstract: Epstein-Barr virus (EBV) drives over 200,000 cancer cases annually, including diffuse large B-cell lymphoma, Burkitt lymphoma, and classic Hodgkin lymphoma-malignancies that frequently originate from germinal centers (GCs), which are physiolog...
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Antibody iDeal ChIP-seq Kit for Histones

Sox8 is essential for vertebrate gastrulation
Published: November, 2025

Abstract: Gastrulation is a fundamental developmental process during which germ layers are formed and the body axes are defined by the precise orchestration of cell movements and fate specification. Here, we identify the SOXE transcription factor Sox8 as ...
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Antibody

Epigenomics of embryogenesis in turbot
Published: November, 2025

Abstract: Embryogenesis is the foundational step of ontogeny, where a complex organism emerges from a single totipotent cell. This process is orchestrated by changes in transcriptional regulation, influenced by chromatin accessibility and epigenetic mod...
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Antibody ChIPmentation

Epigenetic control of microglial developmental milestones from proliferative progenitors to efficient phagocytes
Published: November, 2025

Abstract: Early immune perturbations increase the risk of neurodegenerative and neurodevelopmental disorders, yet the mechanisms underlying the maturation of microglia, the resident immune cells of the brain parenchyma, remain poorly defined. Specifically, ...
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Antibody Microplex Library Preparation kit True MicroChIP kit

The brain neurovascular epigenome and its association with dementia
Published: October, 2025

Abstract: Cerebral small vessel disease (SVD) is frequently comorbid with Alzheimer's disease (AD), and brain endothelial cells (BECs) express genes associated with AD genetic risk. However, the epigenome of neurovascular cells and its intersection with g...
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Antibody Tagmentase

Disease-specific epigenetic deregulation of enhancers, transposons, and polycomb targets in acute promyelocytic leukemia
Published: October, 2025

Abstract: Background: Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML), characterized by a fusion between the PML and RARA genes and by a block in the myeloid maturation at the promyelocytic stage. Methods: This stu...
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Antibody iDeal ChIP-seq Kit for Histones

Upregulation of ALDH1 as an adaptive epigenetic response to anthracyclines in acute myeloid leukemia
Published: October, 2025

Abstract: Acute myeloid leukemia (AML) is a genetically heterogeneous malignancy characterized by the clonal proliferation of undifferentiated myeloid precursors in the bone marrow. Although standard induction regimens based on anthracyclines often achi...
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Antibody Microplex Library Preparation kit

Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation
Published: October, 2025

Abstract: Enhancing ten-eleven translocation 2 (TET2) activity through genetic or pharmacologic approaches, such as ascorbate supplementation, can slow myeloid malignancy progression. However, ascorbate alone may be insufficient to fully activate TET2 in ...
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Antibody ATAC-seq

PHF19 drives the formation of PRC2 clusters to enhance motility in TNBC cells
Published: October, 2025

Abstract: Polycomb repressive complex 2 (PRC2) is a key regulator of transcriptional repression and chromatin organization, essential in development and disease. While its enzymatic activity is well characterized, the factors governing PRC2 subnuclear org...
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Antibody Microplex Library Preparation kit

Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer
Published: October, 2025

Abstract: Prostate cancer is driven by oncogenic transcription factor enhanceosomes comprising chromatin and epigenetic regulators. The lysine acetyltransferases p300 and CREB-binding protein (CBP) are key cofactors that activate enhancers through histo...
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Antibody iDeal ChIP-seq Kit for Transcription Factors iDeal ChIP-seq Kit for Histones

Role of MNX1-mediated Histone Modifications and PBX Gene Family in MNX1-induced Leukemogenesis
Published: September, 2025

Abstract: The t(7;12)(q36;p13) AML subtype in pediatric patients is associated with the upregulation of homeodomain protein MNX1 as the initiating event for leukemogenesis. In this study, we investigated the downstream targets of MNX1 and their relation...
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Antibody iDeal ChIP-qPCR

Probing DNA damage in Rett syndrome neurons uncovers a role for MECP2 regulation of PARP1
Published: September, 2025

Abstract: Methyl-CpG-binding protein 2 (MECP2)/Rett syndrome is characterized by a postnatal loss of neurophysiological function and regression of childhood development. While Rett neurons have been described as showing elevated senescence and P53 act...
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Antibody

Anticancer Activity of Jania rubens in HCT-116 Cells via EMT Suppression, TET Downregulation, and ROS-Mediated Cytotoxicity
Published: September, 2025

Abstract: The red seaweed Jania rubens (J. rubens) is prevalent along the Lebanese coast and has drawn attention for its notable antineoplastic properties. Our previous data showed that its dichloromethane–methanol (DM) extract possesses a...
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Antibody

Coordinated control of genome-nuclear lamina interactions by topoisomerase 2B and lamin B receptor
Published: September, 2025

Abstract: Lamina-associated domains (LADs) are megabase-sized genomic regions anchored to the nuclear lamina (NL). Factors controlling the interactions of the genome with the NL have largely remained elusive. Here, we identified DNA topoisomerase 2 beta...
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Antibody

Teamwork of clustered low-affinity κB sites and accessory factors regulates transcriptional strength of NF-κB RelA dimers
Published: September, 2025

Abstract: Non-consensus binding sites of transcription factors (TFs) are often observed within the regulatory elements of genes; however, their effect on transcriptional strength is unclear. Within the promoters and enhancers of NF-κB-responsive g...
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Antibody

XPO1-inhibitor Selinexor induces MGMT expression by activating PKA-CREB signaling in IDH wildtype glioblastoma
Published: September, 2025

Abstract: Purpose: The temozolomide (TMZ) resistance mechanisms in MGMT-promoter methylated IDH wildtype glioblastoma (GBM) tumors are poorly known. This study aimed to identify potential modulators of TMZ resistance in methylated GBM cells. ...
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Antibody

Analog epigenetic memory revealed by targeted chromatin editing
Published: September, 2025

Abstract: Cells store information by means of chromatin modifications that persist through cell divisions and can hold gene expression silenced over generations. However, how these modifications may maintain other gene expression states has remained uncle...
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MagMeDIP kit Antibody True MicroChIP kit

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