Publications

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1425 publications found×

Chromatin profiling reveals TFAP4 as a critical transcriptional regulator of bovine satellite cell differentiation
Published: March, 2024

Abstract: Background Satellite cells are myogenic precursor cells in adult skeletal muscle and play a crucial role in skeletal muscle regeneration, maintenance, and growth. Like embryonic myoblasts, satellite cells have the ability to proliferate, differen...
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Antibody iDeal ChIP-seq Kit for Histones

SURVIVIN IN SYNERGY WITH BAF/SWI COMPLEX BINDS BIVALENT CHROMATIN REGIONS AND ACTIVATES DNA DAMAGE RESPONSE IN CD4+ T CELLS
Published: March, 2024

Abstract: This study explores a regulatory role of oncoprotein survivin on the bivalent regions of chromatin (BvCR) characterized by concomitant deposition of trimethylated lysine of histone H3 at position 4 (H3K4me3) and 27 (H3K27me3). Intersect between B...
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Antibody

In vitro production of cat-restricted Toxoplasma pre-sexual stages
Published: December, 2023

Abstract: Sexual reproduction of Toxoplasma gondii, confined to the felid gut, remains largely uncharted owing to ethical concerns regarding the use of cats as model organisms. Chromatin modifiers dictate the developmental fate of the parasite during i...
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Antibody IPure kit iDeal ChIP-seq Kit for Transcription Factors ATAC-seq

SUMO protease FUG1, histone reader AL3 and the PRC1 Complex areintegral to repeat-expansion induced epigenetic silencing in Arabidopsisthaliana
Published: December, 2023

Abstract: Epigenetic gene silencing induced by expanded repeats can cause diverse phenotypes ranging from severe growth defects in plants to genetic diseases such as Friedreich’s ataxia in humans1. The molecular mechanisms underlying repeat expansion-...
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Antibody

An enriched maternal environment and stereotypies of sows differentiallyaffect the neuro-epigenome of brain regions related to emotionality intheir piglets.
Published: December, 2023

Abstract: Epigenetic mechanisms are important modulators of neurodevelopmental outcomes in the offspring of animals challenged during pregnancy. Pregnant sows living in a confined environment are challenged with stress and lack of stimulation which may resu...
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Antibody

KDM6B drives epigenetic reprogramming associated with lymphoid stromal cell early commitment and immune properties
Published: November, 2023

Abstract: Mature lymphoid stromal cells (LSCs) are key organizers of immune responses within secondary lymphoid organs. Similarly, inflammation-driven tertiary lymphoid structures depend on immunofibroblasts producing lymphoid cytokines and chemokines. Rece...
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Antibody

H3K9 methylation patterns during somatic embryogenic competenceexpression in tamarillo (Solanum betaceum Cav.)
Published: November, 2023

Abstract: The capacity to regenerate is intrinsic to plants and is the basis of natural asexual propagation and artificial cloning. Despite there are different ways of plant regeneration, they all require a change in cell fate and pluripotency reacquisition...
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Antibody

ThPOK is a critical multifaceted regulator of myeloid lineagedevelopment.
Published: August, 2023

Abstract: The transcription factor ThPOK (encoded by Zbtb7b) is well known for its role as a master regulator of CD4 lineage commitment in the thymus. Here, we report an unexpected and critical role of ThPOK as a multifaceted regulator of myeloid lineage co...
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Antibody iDeal ChIP-seq Kit for Transcription Factors

Zfp296 knockout enhances chromatin accessibility and induces a uniquestate of pluripotency in embryonic stem cells.
Published: July, 2023

Abstract: The Zfp296 gene encodes a zinc finger-type protein. Its expression is high in mouse embryonic stem cells (ESCs) but rapidly decreases following differentiation. Zfp296-knockout (KO) ESCs grew as flat colonies, which were reverted to rounded coloni...
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Antibody Tagmentase

Carnobacterium maltaromaticum boosts intestinal vitamin D production tosuppress colorectal cancer in female mice.
Published: July, 2023

Abstract: Carnobacterium maltaromaticum was found to be specifically depleted in female patients with colorectal cancer (CRC). Administration of C.Â maltaromaticum reduces intestinal tumor formation in two murine CRC models in a female-specific m...
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Antibody

Enhanced frequency of transcription pre-initiation complexes assemblyafter exposure to UV irradiation results in increased repair activity andreduced probabilities for mutagenesis.
Published: July, 2023

Abstract: In addition to being essential for gene expression, transcription is crucial for the maintenance of genome integrity. Here, we undertook a systematic approach, to monitor the assembly kinetics of the pre-initiating RNA Polymerase (Pol) II at promo...
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Antibody

ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acidreceptor-mediated DNA polymerase Î¸ expression.
Published: July, 2023

Abstract: Poly (ADP-ribose) Polymerase (PARP) inhibitors (PARPi) have been approved for both frontline and recurrent setting in ovarian cancer with homologous recombination (HR) repair deficiency. However, more than 40\% of BRCA1/2-mutated ovarian cancer la...
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Antibody

Opposing gene regulatory programs governing myofiber development andmaturation revealed at single nucleus resolution.
Published: July, 2023

Abstract: Skeletal muscle fibers express distinct gene programs during development and maturation, but the underlying gene regulatory networks that confer stage-specific myofiber properties remain unknown. To decipher these distinctive gene programs and how...
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Antibody

Alterations in the hepatocyte epigenetic landscape in steatosis.
Published: July, 2023

Abstract: Fatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular carcinoma. Yet, little is known about ...
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Antibody

SMYD3 represses tumor-intrinsic interferon response in HPV-negativesquamous cell carcinoma of the head and neck.
Published: July, 2023

Abstract: Cancers often display immune escape, but the mechanisms are incompletely understood. Herein, we identify SMYD3 as a mediator of immune escape in human papilloma virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC), an aggressive dise...
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Antibody

DeSUMOylation of chromatin-bound proteins limits the rapidtranscriptional reprogramming induced by daunorubicin in acute myeloidleukemias.
Published: July, 2023

Abstract: Genotoxicants have been used for decades as front-line therapies against cancer on the basis of their DNA-damaging actions. However, some of their non-DNA-damaging effects are also instrumental for killing dividing cells. We report here that the a...
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Antibody

RNA polymerase II CTD is dispensable for transcription and requiredfor termination in human cells.
Published: July, 2023

Abstract: The largest subunit of RNA polymerase (Pol) II harbors an evolutionarily conserved C-terminal domain (CTD), composed of heptapeptide repeats, central to the transcriptional process. Here, we analyze the transcriptional phenotypes of a CTD-Î&...
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Antibody

Net39 protects muscle nuclei from mechanical stress during thepathogenesis of Emery-Dreifuss muscular dystrophy.
Published: July, 2023

Abstract: Mutations in genes encoding nuclear envelope proteins lead to diseases known as nuclear envelopathies, characterized by skeletal muscle and heart abnormalities, such as Emery-Dreifuss muscular dystrophy (EDMD). The tissue-specific role of the nucl...
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Antibody

Polycomb protein SCML2 mediates paternal epigenetic inheritance throughsperm chromatin.
Published: June, 2023

Abstract: Sperm chromatin retains small amounts of histones, and chromatin states of sperm mirror gene expression programs of the next generation. However, it remains largely unknown how paternal epigenetic information is transmitted through sperm chromatin...
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Antibody

Nicotinamide N-methyltransferase sustains a core epigenetic programthat promotes metastatic colonization in breast cancer.
Published: June, 2023

Abstract: Metastatic colonization of distant organs accounts for over 90% of deaths related to solid cancers, yet the molecular determinants of metastasis remain poorly understood. Here, we unveil a mechanism of colonization in the aggressive basal-like sub...
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Antibody

SMYD3: a new regulator of the early steps of adipocyte differentiation
Published: June, 2023

Abstract: In obesity, adipose tissue undergoes a remodeling process characterized by increased adipocyte size (hypertrophia) and number (hyperplasia). The individual ability to tip the balance toward the hyperplastic growth, with recruitment of new fat cell...
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Antibody

Single-cell m6A mapping in vivo using picoMeRIP-seq
Published: June, 2023

Abstract: Current N-methyladenosine (mA) mapping methods need large amounts of RNA or are limited to cultured cells. Through optimized sample recovery and signal-to-noise ratio, we developed picogram-scale mA RNA immunoprecipitation and sequencing (picoMeRI...
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Antibody

NUP98 and RAE1 sustain progenitor function through HDAC-dependentchromatin targeting to escape from nucleolar localization.
Published: June, 2023

Abstract: Self-renewing somatic tissues rely on progenitors to support the continuous tissue regeneration. The gene regulatory network maintaining progenitor function remains incompletely understood. Here we show that NUP98 and RAE1 are highly expressed in ...
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Antibody

Bioengineering novel AAV9-mGULO-GT for multi-disease gene therapy:Targeting mutated GULO expression to cure scurvy and brain diseases.
Published: June, 2023

Abstract: Current clinical breakthroughs in gene therapy have brought adeno-associated virus (AAV) vectors to the forefront of gene delivery systems. Vitamin C deficiency due to GULO mutations is a genetic disorder affecting guinea pigs and humans. In our s...
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Antibody

In skeletal muscle and neural crest cells, SMCHD1 regulates biologicalpathways relevant for Bosma syndrome and facioscapulohumeral dystrophyphenotype.
Published: June, 2023

Abstract: Many genetic syndromes are linked to mutations in genes encoding factors that guide chromatin organization. Among them, several distinct rare genetic diseases are linked to mutations in SMCHD1 that encodes the structural maintenance of chromosomes...
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Antibody iDeal ChIP-seq Kit for Transcription Factors iDeal ChIP-seq Kit for Histones Infinium Human MethylationEPIC Array Service

Vitamin D Receptor Cross-talk with p63 Signaling PromotesEpidermal Cell Fate.
Published: June, 2023

Abstract: The vitamin D receptor with its ligand 1,25 dihydroxy vitamin D (1,25D) regulates epidermal stem cell fate, such that VDR removal from Krt14 expressing keratinocytes delays re-epithelialization of epidermis after wound injury in mice. In this stud...
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Antibody iDeal ChIP-seq Kit for Transcription Factors

Mu opioid receptor expressing neurons in the rostral ventromedial medullaare the source of mechanical hypersensitivity induced by repeated restraintstress.
Published: June, 2023

Abstract: Repeated exposure to psychophysical stress often causes an increase in sensitivity and response to pain. This phenomenon is commonly called stress-induced hyperalgesia (SIH). Although psychophysical stress is a well-known risk factor for numerous ...
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Antibody

SALL1 enforces microglia-specific DNA binding and function of SMADsto establish microglia identity.
Published: June, 2023

Abstract: Spalt-like transcription factor 1 (SALL1) is a critical regulator of organogenesis and microglia identity. Here we demonstrate that disruption of a conserved microglia-specific super-enhancer interacting with the Sall1 promoter results in complete...
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Antibody

Sexual differentiation in human malaria parasites is regulated bycompetition between phospholipid metabolism and histone methylation.
Published: June, 2023

Abstract: For Plasmodium falciparum, the most widespread and virulent malaria parasite that infects humans, persistence depends on continuous asexual replication in red blood cells, while transmission to their mosquito vector requires asexual blood-stage pa...
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Antibody

Identification of a deltaNp63-Dependent Basal-Like ASubtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma.
Published: June, 2023

Abstract: A major hurdle to the application of precision oncology in pancreatic cancer is the lack of molecular stratification approaches and targeted therapy for defined molecular subtypes. In this work, we sought to gain further insight and identify molec...
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