Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells Published: June, 2025 Abstract:
Iron is an irreplaceable co-factor for metabolism. Iron deficiency affects >1 billion people and decreased iron availability impairs immunity. Nevertheless, how iron deprivation impacts immune cell function remains poorly characterised. We ... Read more » Tags Antibody
HSV-1 infection induces a downstream shift of the +1 nucleosome Published: March, 2025 Abstract:
Herpes simplex virus 1 (HSV-1) infection induces a loss of host transcriptional activity and widespread disruption of host transcription termination, which leads to an induction of open chromatin downstream of genes. In this study, we show that ly... Read more » Tags Antibody
m3C is a mitochondrial mRNA modification which promotes tumor progression Published: January, 2025 Abstract:
Mitochondrial mRNA modifications are suggested to play a role in fine-tuning mitochondrial gene expression and function. However, the epitranscriptomic landscape of mitochondrial mRNA (mt-mRNA) remains poorly explored. Here, we uncover N3-methylcy... Read more » Tags Antibody
Nuclear localization of MTHFD2 is required for correct mitosis progression Published: November, 2024 Abstract:
Subcellular compartmentalization of metabolic enzymes establishes a unique metabolic environment that elicits specific cellular functions. Indeed, the nuclear translocation of certain metabolic enzymes is required for epigenetic regulation and gen... Read more » Tags Antibody
