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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
Charting the regulatory landscape of TP53 on transposable elements in cancer
Published: May, 2025
Abstract: The relationship between TP53 and transposable elements (TEs) has been obscure. Given the important role of TEs in oncogenesis, a comprehensive profiling of TE expression dynamics under the regulation of TP53 provides valuable resources for more c...
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Antibody iDeal ChIP-seq Kit for Transcription Factors
Epstein-Barr Virus-Driven B-Cell Transformation under Germinal Center Hypoxia Requires External Unsaturated Fatty Acids
Published: April, 2025
Abstract: Epstein-Barr virus (EBV) contributes to over 200,000 cancers annually, predominantly aggressive lymphomas originating from hypoxic germinal centers (< 1% O2). However, conventional models fail to recapitulate the physiologically relevant hypoxi...
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Antibody iDeal ChIP-seq Kit for Histones
The establishment of nuclear organization in mouse embryos is orchestrated by multiple epigenetic pathways
Published: April, 2025
Abstract: The folding of the genome in the 3D nuclear space is fundamental for regulating all DNA-related processes. The association of the genome with the nuclear lamina into lamina-associated domains (LADs) represents the earliest feature of nuclear org...
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Antibody CUT&Tag
HSV-1 infection induces a downstream shift of the +1 nucleosome
Published: March, 2025
Abstract: Herpes simplex virus 1 (HSV-1) infection induces a loss of host transcriptional activity and widespread disruption of host transcription termination, which leads to an induction of open chromatin downstream of genes. In this study, we show that ly...
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Antibody
Plasma cell-free DNA chromatin immunoprecipitation profiling depicts phenotypic and clinical heterogeneity in advanced prostate cancer
Published: February, 2025
Abstract: Cell phenotype underlies prostate cancer presentation and treatment resistance and can be regulated by epigenomic features. However, the osteotropic tendency of prostate cancer limits access to metastatic tissue, meaning most prior insights into p...
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Antibody
CRISPR screening identifies regulators of enhancer-mediated androgen receptor transcription in advanced prostate cancer
Published: February, 2025
Abstract: Amplification of the androgen receptor (AR) locus is the most frequent alteration in metastatic castration-resistant prostate cancer (CRPC). Recently, it was discovered that an enhancer of the AR is co-amplified with the AR gene body and c...
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Antibody ATAC-seq
Accelerated epigenetic aging in Huntington’s disease involves polycomb repressive complex 1
Published: February, 2025
Abstract: Loss of epigenetic information during physiological aging compromises cellular identity, leading to de-repression of developmental genes. Here, we assessed the epigenomic landscape of vulnerable neurons in two reference mouse models of Huntington ...
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Antibody Microplex Library Preparation kit CUT&Tag
Trithorax regulates long-term memory in Drosophila through epigenetic maintenance of mushroom body metabolic state and translation capacity
Published: January, 2025
Abstract: The role of epigenetics and chromatin in the maintenance of postmitotic neuronal cell identities is not well understood. Here, we show that the histone methyltransferase Trithorax (Trx) is required in postmitotic memory neurons of the Drosoph...
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Antibody Microplex Library Preparation kit True MicroChIP kit
Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow
Published: January, 2025
Abstract: Highlights Gut barrier disruption induces trained immunity in bone marrow progenitors Enterococcus faecalis translocates to the bone marrow, inducing trained immunity Mincle sensing of E. faecalis m...
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Antibody CUT&Tag
Motif distribution and DNA methylation underlie distinct Cdx2 binding during development and homeostasis
Published: January, 2025
Abstract: Transcription factors guide tissue development by binding to developmental stage-specific targets and establishing an appropriate enhancer landscape. In turn, DNA and chromatin modifications direct the genomic binding of transcription factors. How...
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Antibody
The senolytic cocktail, dasatinib and quercetin, impacts the chromatin structure of both young and senescent vascular smooth muscle cells
Published: January, 2025
Abstract: One promising strategy to alleviate aging symptoms is the treatment with senolytics that is compounds which selectively eliminate senescent cells. Some therapies aim to reduce symptoms of cellular senescence without senescent cell eradication (sen...
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Antibody
m3C is a mitochondrial mRNA modification which promotes tumor progression
Published: January, 2025
Abstract: Mitochondrial mRNA modifications are suggested to play a role in fine-tuning mitochondrial gene expression and function. However, the epitranscriptomic landscape of mitochondrial mRNA (mt-mRNA) remains poorly explored. Here, we uncover N3-methylcy...
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Antibody
MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia
Published: January, 2025
Abstract: Enhancer translocations, due to 3q26 rearrangements, drive out-of-context MECOM expression in an aggressive subtype of acute myeloid leukemia (AML). Direct depletion of MECOM using an endogenous auxin-inducible degron immediately upregulates expre...
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Antibody Microplex Library Preparation kit
Exploring the Epigenetic Landscape of Spermatozoa: Impact of Oxidative Stress and Antioxidant Supplementation on DNA Methylation and Hydroxymethylation
Published: December, 2024
Abstract: Reproductive success is dependent on gamete integrity, and oxidative stress alters male nuclei, meaning that no DNA repair is possible due to chromatin compaction. The composition of sperm makes it highly sensitive to reactive oxygen species (ROS)...
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Antibody
EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling
Published: December, 2024
Abstract: Highlights Enhancer chromatin is dynamically remodeled during mesoderm/endoderm (ME) differentiation Global ME enhancer accessibility during pluripotency exit relies on the Tbx factor EOMES EOMES and SWI/SNF cooperate ...
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Antibody iDeal ChIP-seq Kit for Transcription Factors
Interferon-gamma rescues FK506 dampened dendritic cell calcineurin-dependent responses to Aspergillus fumigatus via Stat3 to Stat1 switching
Published: December, 2024
Abstract: IScience Highlights Calcineurin inhibitors block DC maturation in response to A. fumigatus Lack of DC maturation impairs Th1 polarization in response to A. fumigatus Interferon-γ restores maturation, pr...
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Antibody IPure kit Microplex Library Preparation kit iDeal ChIP-seq Kit for Histones
Epi-microRNA mediated metabolic reprogramming counteracts hypoxia to preserve affinity maturation
Published: December, 2024
Abstract: To increase antibody affinity against pathogens, positively selected GC-B cells initiate cell division in the light zone (LZ) of germinal centers (GCs). Among these, higher-affinity clones migrate to the dark zone (DZ) and vigorously proliferate b...
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Microplex Library Preparation kit
NUP98 fusion proteins and KMT2A-MENIN antagonize PRC1.1 to drive gene expression in AML
Published: November, 2024
Abstract: Highlights Degradation of NUP98-fp halts nascent transcription of key oncogenes within 1 h NUP98-fp loss results in accumulation of PRC1.1 and repressive histone modifications PRC1.1 is needed for stable gene repress...
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Antibody
Peroxiredoxin 1-Toll-like receptor 4-p65 axis inhibits receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation
Published: November, 2024
Abstract: Peroxiredoxin 1 (PRDX1), an intracellular antioxidant enzyme, has emerged as a regulator of inflammatory responses via Toll-like receptor 4 (TLR4) signaling. Despite this, the mechanistic details of the PRDX1-TLR4 axis and its impact on osteoclast...
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Antibody
Nuclear localization of MTHFD2 is required for correct mitosis progression
Published: November, 2024
Abstract: Subcellular compartmentalization of metabolic enzymes establishes a unique metabolic environment that elicits specific cellular functions. Indeed, the nuclear translocation of certain metabolic enzymes is required for epigenetic regulation and gen...
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Antibody
Claudin-1 as a potential marker of stress-induced premature senescence in vascular smooth muscle cells
Published: November, 2024
Abstract: Cellular senescence, a permanent state of cell cycle arrest, can result either from external stress and is then called stress-induced premature senescence (SIPS), or from the exhaustion of cell division potential giving rise to replicative senesce...
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Antibody iDeal ChIP-seq Kit for Histones
A multidimensional recommendation framework for identifying biological targets to aid the diagnosis and treatment of liver metastasis in patients with colorectal cancer
Published: October, 2024
Abstract: The quest to understand the molecular mechanisms of tumour metastasis and identify pivotal biomarkers for cancer therapy is increasing in importance. Single-omics analyses, constrained by their focus on a single biological layer, cannot fully eluc...
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Antibody
GTSF1 is required for transposon silencing in the unicellular eukaryote Paramecium tetraurelia
Published: October, 2024
Abstract: The PIWI-interacting RNA (piRNA) pathway is crucial for transposon repression and the maintenance of genomic integrity. Gametocyte-specific factor 1 (GTSF1), a PIWI-associated protein indispensable for transposon repression, has been recently show...
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Antibody
Dysregulation of pseudouridylation in small RNAs contributes to papillary thyroid carcinoma metastasis
Published: October, 2024
Abstract: Background Previous studies have indicated that ψ-modified small RNAs play crucial roles in tumor metastasis. However, the ψ-modified small RNAs during metastasis of PTC are still unclear. Methods We compared the pseudouridine synthase ...
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Antibody
The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency
Published: October, 2024
Abstract: Background The epigenetic factors KAT6A (MOZ/MYST3) and KMT2A (MLL/MLL1) interact in normal hematopoiesis to regulate progenitors’ self-renewal. Both proteins are recurrently translocated in AML, leading to impairment of critical differenti...
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Antibody Microplex Library Preparation kit
Integrated multi-omics analysis of PBX1 in mouse adult neural stem- and progenitor cells identifies a transcriptional module that functionally links PBX1 to TCF3/4
Published: October, 2024
Abstract: Developmental transcription factors act in networks, but how these networks achieve cell- and tissue specificity is still poorly understood. Here, we explored pre-B cell leukemia homeobox 1 (PBX1) in adult neurogenesis combining genomic, transcrip...
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Antibody Microplex Library Preparation kit
5-Hydroxymethylcytosine in circulating cell-free DNA as a potential diagnostic biomarker for SLE
Published: October, 2024
Abstract: Background SLE is a complex autoimmune disease with heterogeneous manifestations and unpredictable outcomes. Early diagnosis is challenging due to non-specific symptoms, and current treatments only manage symptoms. Epigenetic alternations, ...
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Antibody
RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis
Published: October, 2024
Abstract: Mutation of tet methylcytosine dioxygenase 2 (encoded by TET2) drives myeloid malignancy initiation and progression1,2,3. TET2 deficiency is known to cause a globally opened chromatin state and activation of genes contributing to aberrant hae...
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Antibody
Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling
Published: September, 2024
Abstract: Trained immunity is characterized by histone modifications and metabolic changes in innate immune cells following exposure to inflammatory signals, leading to heightened responsiveness to secondary stimuli. Although our understanding of the molecu...
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Antibody
Legionella pneumophila modulates macrophage functions through epigenetic reprogramming via the C-type lectin receptor Mincle
Published: September, 2024
Abstract: Legionella pneumophila is a pathogen which can lead to a severe form of pneumonia in humans known as Legionnaires disease after replication in alveolar macrophages. Viable L. pneumophila actively secrete effector molecules to m...
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Antibody

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