ThPOK is a critical multifaceted regulator of myeloid lineagedevelopment. Published: August, 2023 Abstract:
The transcription factor ThPOK (encoded by Zbtb7b) is well known for its role as a master regulator of CD4 lineage commitment in the thymus. Here, we report an unexpected and critical role of ThPOK as a multifaceted regulator of myeloid lineage co... Read more »
Vitamin D Receptor Cross-talk with p63 Signaling PromotesEpidermal Cell Fate. Published: June, 2023 Abstract:
The vitamin D receptor with its ligand 1,25 dihydroxy vitamin D (1,25D) regulates epidermal stem cell fate, such that VDR removal from Krt14 expressing keratinocytes delays re-epithelialization of epidermis after wound injury in mice. In this stud... Read more »
Expression of RNA polymerase I catalytic core is influenced byRPA12. Published: January, 2023 Abstract:
RNA Polymerase I (Pol I) has recently been recognized as a cancer therapeutic target. The activity of this enzyme is essential for ribosome biogenesis and is universally activated in cancers. The enzymatic activity of this multi-subunit complex re... Read more »
CRISPR off-target detection with DISCOVER-seq. Published: April, 2020 Abstract:
DISCOVER-seq (discovery of in situ Cas off-targets and verification by sequencing) is a broadly applicable approach for unbiased CRISPR-Cas off-target identification in cells and tissues. It leverages the recruitment of DNA repair factors to doubl... Read more »
17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Published: October, 2019 Abstract:
Heat Shock Factor 1 (HSF1) is a key regulator of gene expression during acute environmental stress that enables the cell survival, which is also involved in different cancer-related processes. A high level of HSF1 in estrogen receptor (ER)-positiv... Read more »
Guidelines for optimized gene knockout using CRISPR/Cas9 Published: May, 2019 Abstract:
CRISPR/Cas9 technology has evolved as the most powerful approach to generate genetic models both for fundamental and preclinical research. Despite its apparent simplicity, the outcome of a genome-editing experiment can be substantially impacted by... Read more »
The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis. Published: August, 2018 Abstract:
Chromatin remodeler Brahma related gene 1 (BRG1) is silenced in approximately 10% of human pancreatic ductal adenocarcinomas (PDAs). We previously showed that BRG1 inhibits the formation of intraductal pancreatic mucinous neoplasm (IPMN) and that ... Read more »
Corticosteroid receptors adopt distinct cyclical transcriptional signatures Published: May, 2018 Abstract:
Mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) are two closely related hormone-activated transcription factors that regulate major pathophysiologic functions. High homology between these receptors accounts for the crossbindin... Read more »
Corticosteroid receptors adopt distinct cyclical transcriptional signatures. Published: May, 2018 Abstract:
Mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) are two closely related hormone-activated transcription factors that regulate major pathophysiologic functions. High homology between these receptors accounts for the crossbindin... Read more »
