ZEB1 transcription factor induces tumor cell PD-L1 expression in melanoma Published: March, 2025 Abstract:
Tumor cells can evade antitumor immune response by expressing the PD-L1 ligand, leading to the inhibition of PD-1-expressing T lymphocytes. The mechanisms that regulate PD-L1 expression in cancer cells are imperfectly characterized. The transcript... Read more »
TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway Published: November, 2024 Abstract:
TEAD proteins are the main transcriptional effectors of the Hippo signaling pathway and a pharmacological target in oncology. Most TEAD-targeting small molecules act by disrupting interaction with the oncogenic transcriptional activators YAP and T... Read more »
In vitro production of cat-restricted Toxoplasma pre-sexual stages Published: December, 2023 Abstract:
Sexual reproduction of Toxoplasma gondii, confined to the felid gut, remains largely uncharted owing to ethical concerns regarding the use of cats as model organisms. Chromatin modifiers dictate the developmental fate of the parasite during i... Read more »
ThPOK is a critical multifaceted regulator of myeloid lineagedevelopment. Published: August, 2023 Abstract:
The transcription factor ThPOK (encoded by Zbtb7b) is well known for its role as a master regulator of CD4 lineage commitment in the thymus. Here, we report an unexpected and critical role of ThPOK as a multifaceted regulator of myeloid lineage co... Read more »
Vitamin D Receptor Cross-talk with p63 Signaling PromotesEpidermal Cell Fate. Published: June, 2023 Abstract:
The vitamin D receptor with its ligand 1,25 dihydroxy vitamin D (1,25D) regulates epidermal stem cell fate, such that VDR removal from Krt14 expressing keratinocytes delays re-epithelialization of epidermis after wound injury in mice. In this stud... Read more »
Expression of RNA polymerase I catalytic core is influenced byRPA12. Published: January, 2023 Abstract:
RNA Polymerase I (Pol I) has recently been recognized as a cancer therapeutic target. The activity of this enzyme is essential for ribosome biogenesis and is universally activated in cancers. The enzymatic activity of this multi-subunit complex re... Read more »
CRISPR off-target detection with DISCOVER-seq. Published: April, 2020 Abstract:
DISCOVER-seq (discovery of in situ Cas off-targets and verification by sequencing) is a broadly applicable approach for unbiased CRISPR-Cas off-target identification in cells and tissues. It leverages the recruitment of DNA repair factors to doubl... Read more »
17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Published: October, 2019 Abstract:
Heat Shock Factor 1 (HSF1) is a key regulator of gene expression during acute environmental stress that enables the cell survival, which is also involved in different cancer-related processes. A high level of HSF1 in estrogen receptor (ER)-positiv... Read more »
Guidelines for optimized gene knockout using CRISPR/Cas9 Published: May, 2019 Abstract:
CRISPR/Cas9 technology has evolved as the most powerful approach to generate genetic models both for fundamental and preclinical research. Despite its apparent simplicity, the outcome of a genome-editing experiment can be substantially impacted by... Read more »
The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis. Published: August, 2018 Abstract:
Chromatin remodeler Brahma related gene 1 (BRG1) is silenced in approximately 10% of human pancreatic ductal adenocarcinomas (PDAs). We previously showed that BRG1 inhibits the formation of intraductal pancreatic mucinous neoplasm (IPMN) and that ... Read more »
Corticosteroid receptors adopt distinct cyclical transcriptional signatures Published: May, 2018 Abstract:
Mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) are two closely related hormone-activated transcription factors that regulate major pathophysiologic functions. High homology between these receptors accounts for the crossbindin... Read more »
Corticosteroid receptors adopt distinct cyclical transcriptional signatures. Published: May, 2018 Abstract:
Mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) are two closely related hormone-activated transcription factors that regulate major pathophysiologic functions. High homology between these receptors accounts for the crossbindin... Read more »
