Tags | Diagenode

Epigenomics of embryogenesis in turbot
Published: November, 2025

Abstract: Embryogenesis is the foundational step of ontogeny, where a complex organism emerges from a single totipotent cell. This process is orchestrated by changes in transcriptional regulation, influenced by chromatin accessibility and epigenetic mod...
Read more »

Time-dependent chromatin maturation during 3D spheroid culture improves preclinical modeling of non-small cell lung cancer
Published: January, 2025

Abstract: Non-small cell lung cancer (NSCLC) is the deadliest cancer worldwide. Therapeutic progress stagnate, highlighting the complexity to replicate NSCLC in preclinical models. Drug discovery studies rely mostly on cancer cells in two-dimension (2D), wh...
Read more »

Epigenetics and suicide: investigating altered H3K14ac unveiled differential expression in ADORA2A, B4GALT2 and MMP14
Published: March, 2024

Abstract: Background: Environmental factors make an important contribution to suicide. Histone tails are prone to different modifications, leading to changes of chromatin (de)condensation and consequently gene expression. Materials & methods:&...
Read more »

Multiomics uncovers the epigenomic and transcriptomic response to viral and bacterial stimulation in turbot
Published: February, 2024

Abstract: Uncovering the epigenomic regulation of immune responses is essential for a comprehensive understanding of host defence mechanisms but remains poorly described in farmed fish. Here, we report the first annotation of the innate immune regulatory re...
Read more »

A dataset of definitive endoderm and hepatocyte differentiations fromhuman induced pluripotent stem cells.
Published: February, 2023

Abstract: Hepatocytes are a major parenchymal cell type in the liver and play an essential role in liver function. Hepatocyte-like cells can be differentiated in vitro from induced pluripotent stem cells (iPSCs) via definitive endoderm (DE)-like cells and h...
Read more »

GATA6 is predicted to regulate DNA methylation in an in vitro model ofhuman hepatocyte differentiation.
Published: May, 2022

Abstract: Hepatocytes are the dominant cell type in the human liver, with functions in metabolism, detoxification, and producing secreted proteins. Although gene regulation and master transcription factors involved in the hepatocyte differentiation have bee...
Read more »

Rhesus macaques self-curing from a schistosome infection can displaycomplete immunity to challenge
Published: October, 2021

Abstract: The rhesus macaque provides a unique model of acquired immunity against schistosomes, which afflict \>200 million people worldwide. By monitoring bloodstream levels of parasite-gut-derived antigen, we show that from week 10 onwards an establish...
Read more »

Niche stiffening compromises hair follicle stem cell potential duringageing by reducing bivalent promoter accessibility.
Published: July, 2021

Abstract: Tissue turnover requires activation and lineage commitment of tissue-resident stem cells (SCs). These processes are impacted by ageing, but the mechanisms remain unclear. Here, we addressed the mechanisms of ageing in murine hair follicle SCs (HFS...
Read more »

ChIPmentation

活动