m3C is a mitochondrial mRNA modification which promotes tumor progression Published: January, 2025 Abstract:
Mitochondrial mRNA modifications are suggested to play a role in fine-tuning mitochondrial gene expression and function. However, the epitranscriptomic landscape of mitochondrial mRNA (mt-mRNA) remains poorly explored. Here, we uncover N3-methylcy... Read more » Tags Antibody
Nuclear localization of MTHFD2 is required for correct mitosis progression Published: November, 2024 Abstract:
Subcellular compartmentalization of metabolic enzymes establishes a unique metabolic environment that elicits specific cellular functions. Indeed, the nuclear translocation of certain metabolic enzymes is required for epigenetic regulation and gen... Read more » Tags Antibody
RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis Published: October, 2024 Abstract:
Mutation of tet methylcytosine dioxygenase 2 (encoded by TET2) drives myeloid malignancy initiation and progression1,2,3. TET2 deficiency is known to cause a globally opened chromatin state and activation of genes contributing to aberrant hae... Read more » Tags Antibody
Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling Published: September, 2024 Abstract:
Trained immunity is characterized by histone modifications and metabolic changes in innate immune cells following exposure to inflammatory signals, leading to heightened responsiveness to secondary stimuli. Although our understanding of the molecu... Read more » Tags Antibody
RNA sequestration in P-bodies sustains myeloid leukaemia Published: August, 2024 Abstract:
Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial vulnerabilities in acute myeloid leukaemia (AML) through genome-wide... Read more » Tags AntibodyCUT&Tag
LL37/self-DNA complexes mediate monocyte reprogramming Published: August, 2024 Abstract:
LL37 alone and in complex with self-DNA triggers inflammatory responses in myeloid cells and plays a crucial role in the development of systemic autoimmune diseases, like psoriasis and systemic lupus erythematosus. We demonstrated that LL37/self-D... Read more » Tags Antibody
