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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1425 publications found×
The long noncoding RNA H19 regulates tumor plasticity inneuroendocrine prostate cancer
Published: December, 2021
Abstract: Neuroendocrine (NE) prostate cancer (NEPC) is a lethal subtype of castration-resistant prostate cancer (PCa) arising either de novo or from transdifferentiated prostate adenocarcinoma following androgen deprivation therapy (ADT). Extensive computa...
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Antibody
Epigenetic Silencing of OR and TAS2R Genes Expression inHuman Orbitofrontal Cortex At Early Stages of SporadicAlzheimer’s Disease
Published: December, 2021
Abstract: Modulation of brain olfactory (OR) and taste receptors (TASR) expression was recently reported in neurological diseases. We explored the possible expression and regulation of selected OR and TASR genes in human orbitofrontal cortex of sporadic Alz...
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Antibody
Gene bookmarking by the heat shock transcription factor programs theinsulin-like signaling pathway.
Published: December, 2021
Abstract: Maternal stress can have long-lasting epigenetic effects on offspring. To examine how epigenetic changes are triggered by stress, we examined the effects of activating the universal stress-responsive heat shock transcription factor HSF-1 in the ge...
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Antibody
Epromoters function as a hub to recruit key transcription factorsrequired for the inflammatory response
Published: November, 2021
Abstract: Gene expression is controlled by the involvement of gene-proximal (promoters) and distal (enhancers) regulatory elements. Our previous results demonstrated that a subset of gene promoters, termed Epromoters, work as bona fide enhancers and regulat...
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Antibody Microplex Library Preparation kit
Comparing the epigenetic landscape in myonuclei purified with a PCM1antibody from a fast/glycolytic and a slow/oxidative muscle.
Published: November, 2021
Abstract: Muscle cells have different phenotypes adapted to different usage, and can be grossly divided into fast/glycolytic and slow/oxidative types. While most muscles contain a mixture of such fiber types, we aimed at providing a genome-wide analysis of ...
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Antibody
Conditional depletion of transcriptional kinases Ctk1 and Bur1 andeffects on co-transcriptional spliceosome assembly and pre-mRNA splicing.
Published: November, 2021
Abstract: From yeast to humans, pre-mRNA splicing occurs mainly co-transcriptionally, with splicing and transcription functionally coupled such that they influence one another. The recruitment model of co-transcriptional splicing proposes that core members ...
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Antibody
ATRX regulates glial identity and the tumor microenvironment inIDH-mutant glioma
Published: November, 2021
Abstract: Background Recent single-cell transcriptomic studies report that IDH-mutant gliomas share a common hierarchy of cellular phenotypes, independent of genetic subtype. However, the genetic differences between IDH-mutant glioma subtypes are prognostic...
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Antibody CUT&Tag
Short-Chain Fatty Acids Calibrate RARα Activity RegulatingFood Sensitization
Published: October, 2021
Abstract: Gut-microbiota dysbiosis links to allergic diseases. The mechanism of the exacerbation of food allergy caused by gut-microbiota dysbiosis remains unknown. Regulation of retinoic acid receptor alpha (RARα) signaling is critical for gut immune...
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Antibody
Rhesus macaques self-curing from a schistosome infection can displaycomplete immunity to challenge
Published: October, 2021
Abstract: The rhesus macaque provides a unique model of acquired immunity against schistosomes, which afflict \>200 million people worldwide. By monitoring bloodstream levels of parasite-gut-derived antigen, we show that from week 10 onwards an establish...
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Antibody IP-Star Compact ChIPmentation
Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASRcomplex in mouse models
Published: October, 2021
Abstract: Rett syndrome (RTT) is a severe neurological disorder and a leading cause of intellectual disability in young females. RTT is mainly caused by mutations found in the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2). Despite extensive st...
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Antibody
SETD2-mediated epigenetic regulation of noncanonical Wnt5A duringosteoclastogenesis
Published: October, 2021
Abstract: Graphic abstract To define the role of SETD2 in the WNT5a signaling in the context of osteoclastogenesis, we exploited two different models: in vitro osteoclast differentiation, and K/BxN serum-induced arthritis model. We found that SETD2 and WNT5...
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Antibody
p300 suppresses the transition of myelodysplastic syndromes to acutemyeloid leukemia
Published: October, 2021
Abstract: Myelodysplastic syndromes (MDS) are hematopoietic stem and progenitor cell (HSPC) malignancies characterized by ineffective hematopoiesis and an increased risk of leukemia transformation. Epigenetic regulators are recurrently mutated in MDS, direc...
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Antibody
Tracing the emergence of primordial germ cells from bilaminar disc rabbitembryos and pluripotent stem cells.
Published: October, 2021
Abstract: Rabbit embryos develop as bilaminar discs at gastrulation as in humans and most other mammals, whereas rodents develop as egg cylinders. Primordial germ cells (PGCs) appear to originate during gastrulation according to many systematic studies on m...
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Antibody
NR4A1 regulates expression of immediate early genes, suppressingreplication stress in cancer.
Published: October, 2021
Abstract: Deregulation of oncogenic signals in cancer triggers replication stress. Immediate early genes (IEGs) are rapidly and transiently expressed following stressful signals, contributing to an integrated response. Here, we find that the orphan nuclear ...
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Antibody
Regulatory interplay between Vav1, Syk and β-catenin occurs in lungcancer cells.
Published: October, 2021
Abstract: Vav1 exhibits two signal transducing properties as an adaptor protein and a regulator of cytoskeleton organization through its Guanine nucleotide Exchange Factor module. Although the expression of Vav1 is restricted to the hematopoietic lineage, i...
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Antibody iDeal ChIP-qPCR ChIP Cross-link Gold
MICAL1 regulates actin cytoskeleton organization, directional cellmigration and the growth of human breast cancer cells as orthotopicxenograft tumours.
Published: October, 2021
Abstract: The Molecule Interacting with CasL 1 (MICAL1) monooxygenase has emerged as an important regulator of cytoskeleton organization via actin oxidation. Although filamentous actin (F-actin) increases MICAL1 monooxygenase activity, hydrogen peroxide (HO...
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Antibody CRISPR
Differential contribution to gene expression prediction of histonemodifications at enhancers or promoters.
Published: September, 2021
Abstract: The ChIP-seq signal of histone modifications at promoters is a good predictor of gene expression in different cellular contexts, but whether this is also true at enhancers is not clear. To address this issue, we develop quantitative models to char...
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Antibody
SUV39 SET domains mediate crosstalk of heterochromatic histone marks.
Published: September, 2021
Abstract: The SUV39 class of methyltransferase enzymes deposits histone H3 lysine 9 di- and trimethylation (H3K9me2/3), the hallmark of constitutive heterochromatin. How these enzymes are regulated to mark specific genomic regions as heterochromatic is poor...
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Bioruptor Antibody
Chromosomal variations of species revealed by FISH with rDNAs andcentromeric histone H3 variant associated DNAs
Published: September, 2021
Abstract: Lycoris species have various chromosome numbers and karyotypes, but all have a constant total number of chromosome major arms. In addition to three fundamental types, including metacentric (M-), telocentric (T-), and acrocentric (A-) chromosomes, ...
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Universal Plant ChIP-seq Kit
Coordination of EZH2 and SOX2 specifies human neural fate decision.
Published: September, 2021
Abstract: Polycomb repressive complexes (PRCs) are essential in mouse gastrulation and specify neural ectoderm in human embryonic stem cells (hESCs), but the underlying molecular basis remains unclear. Here in this study, by employing an array of different ...
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Antibody
Interactome Networks of FOSL1 and FOSL2 in Human Th17 Cells.
Published: September, 2021
Abstract: Dysregulated function of Th17 cells has implications in immunodeficiencies and autoimmune disorders. Th17 cell differentiation is orchestrated by a complex network of transcription factors, including several members of the activator protein (AP-1)...
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Antibody
The prolyl-isomerase PIN1 is essential for nuclear Lamin-Bstructure and function and protects heterochromatin under mechanicalstress.
Published: September, 2021
Abstract: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including...
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Antibody
DOT1L O-GlcNAcylation promotes its protein stability andMLL-fusion leukemia cell proliferation.
Published: September, 2021
Abstract: Histone lysine methylation functions at the interface of the extracellular environment and intracellular gene expression. DOT1L is a versatile histone H3K79 methyltransferase with a prominent role in MLL-fusion leukemia, yet little is known about ...
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Antibody
WT1 regulates HOXB9 gene expression in a bidirectional way.
Published: September, 2021
Abstract: The homeoboxB9 (HOXB9) gene is necessary for specification of the anterior-posterior body axis during embryonic development and expressed in various types of cancer. Here we show that the Wilms tumor transcription factor WT1 regulates the HOXB9 ge...
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Antibody
INTS11 regulates hematopoiesis by promoting PRC2 function.
Published: September, 2021
Abstract: INTS11, the catalytic subunit of the Integrator (INT) complex, is crucial for the biogenesis of small nuclear RNAs and enhancer RNAs. However, the role of INTS11 in hematopoietic stem and progenitor cell (HSPC) biology is unknown. Here, we report ...
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Antibody Microplex Library Preparation kit
Histone deacetylase 4 deletion broadly affects cardiac epigeneticrepression and regulates transcriptional susceptibility via H3K9methylation.
Published: September, 2021
Abstract: Histone deacetylase 4 (HDAC4) is a member of class IIa histone deacetylases (class IIa HDACs) and is believed to possess a low intrinsic deacetylase activity. However, HDAC4 sufficiently represses distinct transcription factors (TFs) such as the m...
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IP-Star Antibody
Genome-wide and sister chromatid-resolved profiling of protein occupancyin replicated chromatin with ChOR-seq and SCAR-seq
Published: September, 2021
Abstract: Elucidating the mechanisms underlying chromatin maintenance upon genome replication is critical for the understanding of how gene expression programs and cell identity are preserved across cell divisions. Here, we describe two recently developed t...
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Antibody
Epigenetic remodelling of enhancers in response to estrogen deprivationand re-stimulation.
Published: September, 2021
Abstract: Estrogen hormones are implicated in a majority of breast cancers and estrogen receptor alpha (ER), the main nuclear factor mediating estrogen signaling, orchestrates a complex molecular circuitry that is not yet fully elucidated. Here, we investig...
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Antibody iDeal ChIP-seq Kit for Histones iDeal ChIP-qPCR hMeDIP
Epigenetic control of region-specific transcriptional programs in mousecerebellar and cortical astrocytes.
Published: September, 2021
Abstract: Astrocytes from the cerebral cortex (CTX) and cerebellum (CB) share basic molecular programs, but also form distinct spatial and functional subtypes. The regulatory epigenetic layers controlling such regional diversity have not been comprehensivel...
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Antibody
Activated Histone Acetyltransferase p300/CBP-Related SignallingPathways Mediate Up-Regulation of NADPH Oxidase,Inflammation, and Fibrosis in Diabetic Kidney
Published: August, 2021
Abstract: Accumulating evidence implicates the histone acetylation-based epigenetic mechanisms in the pathoetiology of diabetes-associated micro-/macrovascular complications. Diabetic kidney disease (DKD) is a progressive chronic inflammatory microvascular ...
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Antibody

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