Publications

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1524 publications found×

Germline activity of the heat shock factor HSF-1 programs theinsulin-receptor daf-2 in C. elegans
Published: February, 2021

Abstract: The mechanisms by which maternal stress alters offspring phenotypes remain poorly understood. Here we report that the heat shock transcription factor HSF-1, activated in the C. elegans maternal germline upon stress, epigenetically programs the ins...
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Antibody

The G2-phase enriched lncRNA SNHG26 is necessary for proper cell cycleprogression and proliferation
Published: February, 2021

Abstract: Long noncoding RNAs (lncRNAs) are involved in the regulation of cell cycle, although only a few have been functionally characterized. By combining RNA sequencing and ChIP sequencing of cell cycle synchronized HaCaT cells we have previously identif...
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Antibody

STAG proteins promote cohesin ring loading at R-loops
Published: February, 2021

Abstract: Most studies of cohesin function consider the Stromalin Antigen (STAG/SA) proteins as core complex members given their ubiquitous interaction with the cohesin ring. Here, we provide functional data to support the notion that the SA subunit is not ...
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Antibody

Restricted nucleation and piRNA-mediated establishment of heterochromatinduring embryogenesis in Drosophila miranda
Published: February, 2021

Abstract: Heterochromatin is a key architectural feature of eukaryotic genomes, crucial for silencing of repetitive elements and maintaining genome stability. Heterochromatin shows stereotypical enrichment patterns around centromeres and repetitive sequence...
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Antibody

The epigenetic landscape in purified myonuclei from fast and slow muscles
Published: February, 2021

Abstract: Muscle cells have different phenotypes adapted to different usage and can be grossly divided into fast/glycolytic and slow/oxidative types. While most muscles contain a mixture of such fiber types, we aimed at providing a genome-wide analysis of c...
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Environmental enrichment induces epigenomic and genome organization changesrelevant for cognitive function
Published: February, 2021

Abstract: In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the epigenome and genome organ...
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Antibody

Chromatin dysregulation associated with NSD1 mutation in head and necksquamous cell carcinoma.
Published: February, 2021

Abstract: Chromatin dysregulation has emerged as an important mechanism of oncogenesis. To develop targeted treatments, it is important to understand the transcriptomic consequences of mutations in chromatin modifier genes. Recently, mutations in the histon...
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Antibody Bioruptor Plus IP-Star Compact

Kmt2c mutations enhance HSC self-renewal capacity and convey a selectiveadvantage after chemotherapy.
Published: February, 2021

Abstract: The myeloid tumor suppressor KMT2C is recurrently deleted in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), particularly therapy-related MDS/AML (t-MDS/t-AML), as part of larger chromosome 7 deletions. Here, we show that KMT2C de...
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Antibody

The glucocorticoid receptor recruits the COMPASS complex to regulateinflammatory transcription at macrophage enhancers.
Published: February, 2021

Abstract: Glucocorticoids (GCs) are effective anti-inflammatory drugs; yet, their mechanisms of action are poorly understood. GCs bind to the glucocorticoid receptor (GR), a ligand-gated transcription factor controlling gene expression in numerous cell type...
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Antibody

A Tumor Suppressor Enhancer of PTEN in T-cell development and leukemia
Published: January, 2021

Abstract: Long-range oncogenic enhancers play an important role in cancer. Yet, whether similar regulation of tumor suppressor genes is relevant remains unclear. Loss of expression of PTEN is associated with the pathogenesis of various cancers, including T-...
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Antibody IP-Star Compact

Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination.
Published: January, 2021

Abstract: BCG vaccination can strengthen protection against pathogens through the induction of epigenetic and metabolic reprogramming of innate immune cells, a process called trained immunity. We and others recently demonstrated that mucosal or intravenous ...
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The Essential Function of SETDB1 in Homologous Chromosome Pairing andSynapsis during Meiosis.
Published: January, 2021

Abstract: SETDB1 is a histone-lysine N-methyltransferase critical for germline development. However, its function in early meiotic prophase I remains unknown. Here, we report that Setdb1 null spermatocytes display aberrant centromere clustering during lepto...
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Antibody

Detection of genetic variation and base modifications at base-pairresolution on both DNA and RNA.
Published: January, 2021

Abstract: Accurate decoding of nucleic acid variation is critical to understand the complexity and regulation of genome function. Here we use a single-molecule magnetic tweezer (MT) platform to identify sequence variation and map a range of important epigen...
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Antibody

Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage.
Published: January, 2021

Abstract: HIV-1 latency generates reservoirs that prevent viral eradication by the current therapies. To find strategies toward an HIV cure, detailed understandings of the molecular mechanisms underlying establishment and persistence of the reservoirs are n...
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Antibody

Postoperative abdominal sepsis induces selective and persistent changes inCTCF binding within the MHC-II region of human monocytes.
Published: January, 2021

Abstract: BACKGROUND: Postoperative abdominal infections belong to the most common triggers of sepsis and septic shock in intensive care units worldwide. While monocytes play a central role in mediating the initial host response to infections, sepsis-induce...
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Antibody IP-Star Compact iDeal ChIP-seq Kit for Transcription Factors iDeal ChIP-seq Kit for Histones

The tropical coral displays an unusual chromatin structure and showshistone H3 clipping plasticity upon bleaching.
Published: January, 2021

Abstract: is a hermatypic coral with strong ecological importance. Anthropogenic disturbances and global warming are major threats that can induce coral bleaching, the disruption of the mutualistic symbiosis between the coral host and its endosymbiotic alga...
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Antibody

Induction of epithelial-mesenchymal transition (EMT) by hypoxia-inducedlncRNA through regulating the histone 4 lysine 16 acetylation(H4K16Ac) mark.
Published: January, 2021

Abstract: Hypoxia activates various long noncoding RNAs (lncRNAs) to induce the epithelial-mesenchymal transition (EMT) and tumor metastasis. The hypoxia/HIF-1α-regulated lncRNAs that also regulate a specific histone mark and promote EMT and metastasi...
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Antibody

WAPL maintains a cohesin loading cycle to preserve cell-type-specificdistal gene regulation.
Published: December, 2020

Abstract: The cohesin complex has an essential role in maintaining genome organization. However, its role in gene regulation remains largely unresolved. Here we report that the cohesin release factor WAPL creates a pool of free cohesin, in a process known a...
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Antibody Bioruptor Plus

Promoter-interacting expression quantitative trait loci are enriched forfunctional genetic variants.
Published: December, 2020

Abstract: Expression quantitative trait loci (eQTLs) studies provide associations of genetic variants with gene expression but fall short of pinpointing functionally important eQTLs. Here, using H3K27ac HiChIP assays, we mapped eQTLs overlapping active cis-...
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Antibody

Quantification and epigenetic evaluation of the residual pool of hepatitisB covalently closed circular DNA in long-term nucleoside analogue-treatedpatients.
Published: December, 2020

Abstract: Hepatitis B virus (HBV) covalently closed circular (ccc)DNA is the key genomic form responsible for viral persistence and virological relapse after treatment withdrawal. The assessment of residual intrahepatic cccDNA levels and activity after long...
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Bioruptor Antibody

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis.
Published: December, 2020

Abstract: Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and show exquisite regional and temporal specificity, suggesting a developmental context permissive to their effects. Here we show that 50\% of G34R/V tumors (n&nbs...
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Antibody IP-Star Compact iDeal ChIP-seq Kit for Histones

S-adenosyl-l-homocysteine hydrolase links methionine metabolism to thecircadian clock and chromatin remodeling.
Published: December, 2020

Abstract: Circadian gene expression driven by transcription activators CLOCK and BMAL1 is intimately associated with dynamic chromatin remodeling. However, how cellular metabolism directs circadian chromatin remodeling is virtually unexplored. We report tha...
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EZH2 and KDM6B Expressions Are Associated with Specific EpigeneticSignatures during EMT in Non Small Cell Lung Carcinomas.
Published: December, 2020

Abstract: The role of Epigenetics in Epithelial Mesenchymal Transition (EMT) has recently emerged. Two epigenetic enzymes with paradoxical roles have previously been associated to EMT, EZH2 (Enhancer of Zeste 2 Polycomb Repressive Complex 2 (PRC2) Subunit),...
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IP-Star Antibody iDeal ChIP-seq Kit for Histones

TGFβ promotes widespread enhancer chromatin opening and operates ongenomic regulatory domains.
Published: December, 2020

Abstract: The Transforming Growth Factor-β (TGFβ) signaling pathway controls transcription by regulating enhancer activity. How TGFβ-regulated enhancers are selected and what chromatin changes are associated with TGFβ-dependent enhancers...
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Antibody CRISPR

PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across thezygote genome.
Published: December, 2020

Abstract: The formation of zygote is the beginning of mammalian life, and dynamic epigenetic modifications are essential for mammalian normal development. H3K27 di-methylation (H3K27me2) and H3K27 tri-methylation (H3K27me3) are marks of facultative het...
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Antibody

Chitosan nano-vehicles as biocompatible delivering tools for a newAg(I)curcuminoid-Gboxin analog complex in cancer and inflammation therapy
Published: December, 2020

Abstract: A novel anticancer and anti-inflammatory agent based on hybrid curcuminoid-Gboxin analog (FLLL49-GbA) and its macromolecular silver(I) complex (Ag(I)FLLL49-GbA) have successfully synthesized. In addition, chitosan nanoparticles (CNPs) were used to...
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Antibody

Kaposi’s Sarcoma-Associated Herpesvirus Processivity Factor,ORF59, Binds to Canonical and Linker Histones, and ItsCarboxy Terminus Is Dispensable for Viral DNA Synthesis
Published: December, 2020

Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus and the causative agent of potentially fatal malignancies. Lytic replication of KSHV is an essential part of the viral life cycle, allowing for virus dissemination within t...
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Antibody iDeal ChIP-seq Kit for Histones

Incretin drugs effect on epigenetic machinery: New potential therapeuticimplications in preventing vascular diabetic complications.
Published: December, 2020

Abstract: The effect of GLP-1R agonists on DNA methylation levels of NF-κB and SOD2 genes in human aortic endothelial cells exposed to high glucose and in diabetic patients treated and not with incretin-based drugs, was evaluated. Methylation levels, ...
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Antibody

Derivation of Intermediate Pluripotent Stem Cells Amenable to PrimordialGerm Cell Specification.
Published: November, 2020

Abstract: Dynamic pluripotent stem cell (PSC) states are in vitro adaptations of pluripotency continuum in vivo. Previous studies have generated a number of PSCs with distinct properties. To date, however, no known PSCs have demonstrated dual comp...
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Antibody iDeal ChIP-seq Kit for Histones

The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cellsexpansion.
Published: November, 2020

Abstract: The gene CXXC5, encoding a Retinoid-Inducible Nuclear Factor (RINF), is located within a region at 5q31.2 commonly deleted in myelodysplastic syndrome (MDS) and adult acute myeloid leukemia (AML). RINF may act as an epigenetic regulator and has be...
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Bioruptor Antibody iDeal ChIP-seq Kit for Transcription Factors

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