Epigenomics Profiling Services

DNA Methylation Profiling Services

DNA-methylation -Diagenode

The pattern of DNA methylation and histone modification(s) plays an essential role in maintaining cellular function. Abnormal DNA methylation – hypermethylation and hypomethylation - can result in adverse outcomes such as cancer or other disease. The quantification of 5-mC through genome-wide DNA methylation analysis can provide information for detection and prognosis of disease. Our DNA methylation analysis services include numerous bisulfite sequencing options for targeted or whole genome DNA methylation analysis across any species.

Our Epigenomics Profiling Services helps you study DNA methylation (5mC) and methylation variants (5hmC). Our experienced scientists will guide you to the best solution according to your needs, depending on whether you want to analyze DNA methylation at genome-wide or gene specific scales. They will process the arrays or generate meaningful libraries for DNA sequencing and deliver high quality data. Our bioinformatic experts will closely work with you to provide standard and customized analysis with comprehensive publication-ready figures.

Infinium MethylationEPIC Array Service V2

  • Cost-effective solution with rapid turnaround time
  • Over 930,000 CpGs detected in human samples at single nucleotide resolution
  • Quantitative interrogation of CpG, non-CpG, and CHH sites
  • Differential methylation analysis using our bioinformatics tools

Reduced Representation Bisulfite Sequencing (RRBS) Service

  • Robust and cost-effective solution with reliable results
  • Unique technology enables low DNA inputs down to 25ng
  • Accurate analyses with UDIs and UMIs
  • Up to 7 million CpGs detected in human samples at single nucleotide resolution
  • Detection of methylation patterns in CpG-rich regions across the genome including promoters and CpG islands
  • Differential methylation analysis using our bioinformatics tools
  • Suitable for epigenetic biomarker discovery

Whole Genome Bisulfite Sequencing (WGBS) or Enzymatic Methylation(EM-seq) Service

  • Very powerful solution for genome-wide biomarker discovery using bisulfite or enzymatic conversion
  • Evaluation of methylation status of nearly every CpG sites of the entire genome at single nucleotide resolution
  • Detection of global methylation patterns including in low CpG-density regions and outside of CpG islands
  • Identification of regions or even loci with differential methylation levels between groups using our bioinformatics tools

Targeted Bisulfite Sequencing Service

  • Focus on DNA methylation patterning of selective regions with single nucleotide resolution
  • Choose between two methodologies depending on the size of the region of interest: PCR enrichment or hybridization capture
  • Enhanced accuracy, sensitivity and specificity while reducing overall cost
  • Allowing deep sequencing at high coverage levels for rare variant identification

Human Methylome

Watch our webinar:

Cost-Effective Genome Wide DNA Methylation Analysis using Twist Hybrid-Capture Methylome Panel

Webinar series: Genome Wide DNA Methylation using Twist Hybrid-Capture Methylome Panel

  • NGS service assay for comprehensive DNA methylation profiling in human samples from solid or liquid biopsy
  • Optimal biomarker discovery tool for cancer, neurodegenerative, cardiovascular and metabolic diseases
  • High coverage for more than 3.89 million methylation sites (~9 million CpGs at single strand level)


Cat. No.ProductFormatPrice
G0209006 NEW Infinium Methylation EPIC Array Service V2
 NEW  The Infinium MethylationEPIC v2.0 Array Services (improved version of the EPIC v1.0) is the new cutting-edge genome-wide DNA methyl...
G02020000 RRBS Service (Reduced Representation Bisulfite Sequencing)
Reduced representation bisulfite sequencing (RRBS) enables genome-scale DNA methylation analysis at the single nucleotide level in any vertebrate specie...
G02040000 WGBS (Whole Genome Bisulfite Sequencing) and EM-seq (Enzymatic Methylation) Service
Whole-genome bisulfite sequencing (WGBS) and Enzymatic Methylation (EM-seq) are the methods of choice for obtaining a comprehensive DNA methylation profiling...
G02100000 Bioinformatics Data Mining Service
New! Data mining using machine learning (AI) for unique epigenetic data insights Watch the webinar to gain insights on how data mining can be applied ...
G02180000 Human Methylome Service
NEW! The Human Methylome is a Next-Generation Sequencing (NGS) service assay that allows a comprehensive DNA methylation profiling in human samples from...
G02160000 Infinium Mouse Methylation Array Service
The Infinium Mouse Methylation Array is a genome-wide DNA methylation analysis technique based on bisulfite conversion and Illumina® technology...
G02070000 Targeted Bisulfite Sequencing Service
Targeted bisulfite sequencing enables DNA methylation analysis of targeted genomic regions with single nucleotide resolution. Depending on the size of the re...


  • FASEB Biological Methylation: Fundamental Mechanisms
    Porto, Portugal
    Jul 28-Aug 1, 2024
 See all events


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