Epigenomics Profiling Services

DNA Methylation Profiling Services

The pattern of DNA methylation and histone modiﬁcation(s) plays an essential role in maintaining cellular function. Abnormal DNA methylation – hypermethylation and hypomethylation - can result in adverse outcomes such as cancer or other disease. The quantification of 5-mC through genome-wide DNA methylation analysis can provide information for detection and prognosis of disease. Our DNA methylation analysis services include numerous bisulfite sequencing options for targeted or whole genome DNA methylation analysis across any species.

Our Epigenomics Profiling Services helps you study DNA methylation (5mC) and methylation variants (5hmC). Our experienced scientists will guide you to the best solution according to your needs, depending on whether you want to analyze DNA methylation at genome-wide or gene specific scales. They will process the arrays or generate meaningful libraries for DNA sequencing and deliver high quality data. Our bioinformatic experts will closely work with you to provide standard and customized analysis with comprehensive publication-ready figures.

Infinium Human MethylationEPIC Array Service

Cost-effective solution with rapid turnaround time
Over 850,000 CpGs detected in human samples at single nucleotide resolution
Quantitative interrogation of CpG, non-CpG, and CHH sites
Differential methylation analysis using our bioinformatics tools

Infinium Mouse Methylation Array Service

Cost-effective solution with rapid turnaround time
Over 285,000 markers detected in mouse samples at single nucleotide resolution
Suitable for common laboratory mouse strains
Differential methylation analysis using our bioinformatics tools

Reduced Representation Bisulfite Sequencing (RRBS) Service

Robust and cost-effective solution with reliable results
Unique technology enables low DNA inputs down to 25ng
Accurate analyses with UDIs and UMIs
Up to 7 million CpGs detected in human samples at single nucleotide resolution
Detection of methylation patterns in CpG-rich regions across the genome including promoters and CpG islands
Differential methylation analysis using our bioinformatics tools
Suitable for epigenetic biomarker discovery

Whole Genome Bisulfite Sequencing (WGBS) or Enzymatic Methylation(EM-seq) Service

Very powerful solution for genome-wide biomarker discovery using bisulfite or enzymatic conversion
Evaluation of methylation status of nearly every CpG sites of the entire genome at single nucleotide resolution
Detection of global methylation patterns including in low CpG-density regions and outside of CpG islands
Identification of regions or even loci with differential methylation levels between groups using our bioinformatics tools

Targeted Bisulfite Sequencing Service

Focus on DNA methylation patterning of selective regions with single nucleotide resolution
Choose between two methodologies depending on the size of the region of interest: PCR enrichment or hybridization capture
Enhanced accuracy, sensitivity and specificity while reducing overall cost
Allowing deep sequencing at high coverage levels for rare variant identification

Methylated DNA IP Sequencing

Immunoprecipitation assay (antibody-based approach) to study 5-mC genome-wide
Resolution of 100-500 bp

Human Methylome

Watch our webinar:

Cost-Effective Genome Wide DNA Methylation Analysis using Twist Hybrid-Capture Methylome Panel

NGS service assay for comprehensive DNA methylation profiling in human samples from solid or liquid biopsy
Optimal biomarker discovery tool for cancer, neurodegenerative, cardiovascular and metabolic diseases
High coverage for more than 3.89 million methylation sites (~9 million CpGs at single strand level)

Products

Cat. No.	Product	Format
G02090000	Infinium MethylationEPIC Array Service The Infinium MethylationEPIC Array is a genome-wide DNA methylation analysis technique based on bisulfite conversion and Illumina® technology. It allows ...		Get a quote You are about to request a quote for our epigenomics services. Fill out the form below and we will be in touch with you very soon. All * fields are mandatory Service Information Which services are you interested in? ChIP-seq ATAC-seq RRBS WGBS MeDIP-seq Targeted DNA methylation analysis Infinium EPIC Array Infinium Mouse Methylation Array RNA-seq Bioinformatics Data mining Sample species Total number of samples (including replicates) Contact Information First name ^* Last name ^* Company ^* Phone number City Country ^* State Email ^* Email verification^* Project ×
G02020000	RRBS Service (Reduced Representation Bisulfite Sequencing) Reduced representation bisulfite sequencing (RRBS) enables genome-scale DNA methylation analysis at the single nucleotide level in any vertebrate specie...		Get a quote You are about to request a quote for our epigenomics services. Fill out the form below and we will be in touch with you very soon. All * fields are mandatory Service Information Which services are you interested in? ChIP-seq ATAC-seq RRBS WGBS MeDIP-seq Targeted DNA methylation analysis Infinium EPIC Array Infinium Mouse Methylation Array RNA-seq Bioinformatics Data mining Sample species Total number of samples (including replicates) Contact Information First name ^* Last name ^* Company ^* Phone number City Country ^* State Email ^* Email verification^* Project ×
G02040000	WGBS (Whole Genome Bisulfite Sequencing) and EM-seq (Enzymatic Methylation) Service Whole-genome bisulfite sequencing (WGBS) and Enzymatic Methylation (EM-seq) are the methods of choice for obtaining a comprehensive DNA methylation profiling...		Get a quote You are about to request a quote for our epigenomics services. Fill out the form below and we will be in touch with you very soon. All * fields are mandatory Service Information Which services are you interested in? ChIP-seq ATAC-seq RRBS WGBS MeDIP-seq Targeted DNA methylation analysis Infinium EPIC Array Infinium Mouse Methylation Array RNA-seq Bioinformatics Data mining Sample species Total number of samples (including replicates) Contact Information First name ^* Last name ^* Company ^* Phone number City Country ^* State Email ^* Email verification^* Project ×
G02100000	Bioinformatics Data Mining Service New! Data mining using machine learning (AI) for unique epigenetic data insights Watch the webinar to gain insights on how data mining can be applied ...	Custom	Get a quote You are about to request a quote for Bioinformatics Data Mining Service. Fill out the form below and we will be in touch with you very soon. All * fields are mandatory Contact Information First name ^* Last name ^* Company ^* Phone number City Country ^* State Email ^* Email verification^* Comment ×
G02180000	Human Methylome Service NEW! The Human Methylome is a Next-Generation Sequencing (NGS) service assay that allows a comprehensive DNA methylation profiling in human samples from...		Get a quote You are about to request a quote for our epigenomics services. Fill out the form below and we will be in touch with you very soon. All * fields are mandatory Service Information Which services are you interested in? ChIP-seq ATAC-seq RRBS WGBS MeDIP-seq Targeted DNA methylation analysis Infinium EPIC Array Infinium Mouse Methylation Array RNA-seq Bioinformatics Data mining Sample species Total number of samples (including replicates) Contact Information First name ^* Last name ^* Company ^* Phone number City Country ^* State Email ^* Email verification^* Project ×
G02160000	Infinium Mouse Methylation Array Service The Infinium Mouse Methylation Array is a genome-wide DNA methylation analysis technique based on bisulfite conversion and Illumina® technology...		Get a quote You are about to request a quote for our epigenomics services. Fill out the form below and we will be in touch with you very soon. All * fields are mandatory Service Information Which services are you interested in? ChIP-seq ATAC-seq RRBS WGBS MeDIP-seq Targeted DNA methylation analysis Infinium EPIC Array Infinium Mouse Methylation Array RNA-seq Bioinformatics Data mining Sample species Total number of samples (including replicates) Contact Information First name ^* Last name ^* Company ^* Phone number City Country ^* State Email ^* Email verification^* Project ×
G02050000	MeDIP-seq service (Methylated DNA IP Sequencing) Methylated DNA immunoprecipitation sequencing (MeDIP-Seq) is used to study 5-mC genome-wide. In this assay, specific antibodies against 5-mC are used to capt...		Get a quote You are about to request a quote for our epigenomics services. Fill out the form below and we will be in touch with you very soon. All * fields are mandatory Service Information Which services are you interested in? ChIP-seq ATAC-seq RRBS WGBS MeDIP-seq Targeted DNA methylation analysis Infinium EPIC Array Infinium Mouse Methylation Array RNA-seq Bioinformatics Data mining Sample species Total number of samples (including replicates) Contact Information First name ^* Last name ^* Company ^* Phone number City Country ^* State Email ^* Email verification^* Project ×
G02070000	Targeted Bisulfite Sequencing Service Targeted bisulfite sequencing enables DNA methylation analysis of targeted genomic regions with single nucleotide resolution. Depending on the size of the re...		Get a quote You are about to request a quote for our epigenomics services. Fill out the form below and we will be in touch with you very soon. All * fields are mandatory Service Information Which services are you interested in? ChIP-seq ATAC-seq RRBS WGBS MeDIP-seq Targeted DNA methylation analysis Infinium EPIC Array Infinium Mouse Methylation Array RNA-seq Bioinformatics Data mining Sample species Total number of samples (including replicates) Contact Information First name ^* Last name ^* Company ^* Phone number City Country ^* State Email ^* Email verification^* Project ×

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