Whole-genome bisulfite sequencing (WGBS) is the method of choice for obtaining a comprehensive DNA methylation profiling, evaluating the methylation patterns of nearly every CpG site of the entire genome. By comparing untreated and bisulfite-treated sequences, the location of the methylated cytosines are determined with accuracy. Genome-wide bisulfite sequencing provides deep insights into gene regulation, allowing identification of novel epigenetic markers and targets for disease.
In-depth DNA methylation analysis
Very powerful solution for genome-wide biomarker discovery
Evaluation of the methylation status of nearly every CpG sites of the entire genome
Detection of global methylation patterns including outside of CpG islands and in low-CpG-density regions
Identification of regions or even loci with differential methylation between groups using bioinformatics tools
Providing a better understanding of development and disease
Comprehensive end-to-end service
From library preparation to data analysis
A dedicated scientist driving your project with high touch communication
Development and epigenetic plasticity of murine Müller glia. Dvoriantchikova G, Seemungal RJ, Ivanov D The ability to regenerate the entire retina and restore lost sight after injury is found in some species and relies mostly on the epigenetic plasticity of Müller glia. To understand the role of mammalian Müller glia as a source of progenitors for retinal regeneration, we investigated changes in gene expres...