Whole-genome bisulfite sequencing (WGBS) and Enzymatic Methylation (EM-seq) are the methods of choice for obtaining a comprehensive DNA methylation profiling, evaluating the methylation patterns of nearly every CpG site of the entire genome. By comparing the proportion of unconverted and converted cytosines at the same location, the methylation levels are determined with accuracy. Genome-wide methylation sequencing (WGBS and EM-seq) provides deep insights into gene regulation, allowing identification of novel epigenetic markers and targets for disease.
In-depth DNA methylation analysis
Very powerful solution for genome-wide biomarker discovery compatible with low input and highly fragmented cfDNA and FFPE samples
Single-nucleotide resolution
Evaluation of the methylation status of nearly every CpG sites of the entire genome
Detection of global methylation patterns including outside of CpG islands and in low-CpG-density regions
Identification of regions or even loci with differential methylation between groups using bioinformatics tools
Identification of methylation pattern/signature predictive and discriminating different groups with Data Mining approach
Providing a better understanding of development and disease
Comprehensive end-to-end service
From DNA QC to sequencing raw data
A dedicated scientist driving your project with high touch communication
Diagenode strongly recommends using this: WGBS (Whole Genome Bisulfite Sequencing) and EM-seq (Enzymatic Methylation) Service (Diagenode Cat# G02040000). Click here to copy to clipboard.
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Development and epigenetic plasticity of murine Müller glia. Dvoriantchikova G, Seemungal RJ, Ivanov D The ability to regenerate the entire retina and restore lost sight after injury is found in some species and relies mostly on the epigenetic plasticity of Müller glia. To understand the role of mammalian Müller glia as a source of progenitors for retinal regeneration, we investigated changes in gene expres...
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