Whole-genome bisulfite sequencing (WGBS) and Enzymatic Methylation (EM-seq) are the methods of choice for obtaining a comprehensive DNA methylation profiling, evaluating the methylation patterns of nearly every CpG site of the entire genome. By comparing the proportion of unconverted and converted cytosines at the same location, the methylation levels are determined with accuracy. Genome-wide methylation sequencing (WGBS and EM-seq) provides deep insights into gene regulation, allowing identification of novel epigenetic markers and targets for disease.
In-depth DNA methylation analysis
- Very powerful solution for genome-wide biomarker discovery compatible with low input and highly fragmented cfDNA and FFPE samples
- Single-nucleotide resolution
- Evaluation of the methylation status of nearly every CpG sites of the entire genome
- Detection of global methylation patterns including outside of CpG islands and in low-CpG-density regions
- Identification of regions or even loci with differential methylation between groups using bioinformatics tools
- Identification of methylation pattern/signature predictive and discriminating different groups with Data Mining approach
- Providing a better understanding of development and disease
Comprehensive end-to-end service
- From DNA QC to sequencing raw data
- A dedicated scientist driving your project with high touch communication
- High-quality bioinformatic support (on request) to assist you with data analysis
See our other DNA Methylation Profiling Services