Epigenomics Profiling Services

Chromatin Profiling Services


Chromatin consists of DNA, histones and non-histone proteins. Understanding the roles of histones and transcription factors is critical in understanding the regulation of gene expression.

Using ChIP-seq analysis, it is possible to profile histone modifications and transcription factor binding genome-wide to elucidate control of gene expression in disease or in response to a drug treatment. Diagenode’s Epigenomic Profiling Services offer a wide variety of chromatin analysis options through ChIP-seq and ATAC-seq.


ATAC-seq: open chromatin regions

Study genome-wide chromatin accessibility. Identify open chromatin sites and active regulatory elements such as promoter, enhancers, and insulators.

    • Nucleosome positioning

ChIP-seq histone modifications

Post-translational modification of histones is implicated in the regulation of gene expression, necessitating the study of regulatory elements and their interacting proteins like active promoter and enhancer analysis. Profile genome-wide histone modifications by ChIP-seq analysis to understand transcriptional regulation

  • Active promoter profiling: H3K4me3 enrichment
  • Inactive promoter profiling: H3K27me3 enrichment
  • Enhancer profiling: H3K4me1 and H3K27ac enrichment in regulatory regions
  • Active gene body: H3K36me3

ChIP-seq Transcription Factors

Explore the effects of transcription factor binding through ChIP-seq analysis of a multitude of TFs including:

  • CTCF: transcriptional repressor and insulator activity
  • p300/CBP: histone acetyltransferase
  • Pol II, p53, and more
  • Epigenetic writers, readers, erasers
  • Nuclear receptors
  • Tumor suppressor genes


Cat. No.ProductFormatPrice
G02060000 ATAC-seq service (Assay for Transposase-Accessible Chromatin)
ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) allows for assessing genome-wide chromatin accessibility. The technology is based on t...
G02010000 ChIP-seq Profiling Service
Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a powerful method allowing the genome-wide identification of DNA binding sites for protein...
G02100000 Bioinformatics Data Mining Service
New! Data mining using machine learning (AI) for unique epigenetic data insights Watch the webinar to gain insights on how data mining can be applied ...


  • EpiPlant 2024
    Clermont-Ferrand, France
    Jul 10-Jul 12, 2024
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