Chromatin consists of DNA, histones and non-histone proteins. Understanding the roles of histones and transcription factors is critical in understanding the regulation of gene expression.
Using ChIP-seq analysis, it is possible to profile histone modifications and transcription factor binding genome-wide to elucidate control of gene expression in disease or in response to a drug treatment. Diagenode’s Epigenomic Profiling Services offer a wide variety of chromatin analysis options through ChIP-seq and ATAC-seq.
Study genome-wide chromatin accessibility. Identify open chromatin sites and active regulatory elements such as promoter, enhancers, and insulators.
Post-translational modification of histones is implicated in the regulation of gene expression, necessitating the study of regulatory elements and their interacting proteins like active promoter and enhancer analysis. Profile genome-wide histone modifications by ChIP-seq analysis to understand transcriptional regulation
Explore the effects of transcription factor binding through ChIP-seq analysis of a multitude of TFs including:
ATAC-seq service (Assay for Transposase-Accessible Chromatin)
ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) allows for assessing genome-wide chromatin accessibility. The technology is based on t...
ChIP-seq/ChIP-qPCR Profiling Service
Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a powerful method allowing the genome-wide identification of DNA binding sites for p...
Bioinformatics Data Mining Service
New! Data mining using machine learning (AI) for unique epigenetic data insights Watch the webinar to gain insights on how data mining can be applied ...