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Epigenomics Profiling Services

Chromatin Profiling Services


Chromatin consists of DNA, histones and non-histone proteins. In forming chromatin, DNA is tightly wrapped around histones. Generally, more highly condensed chromatin is less accessible to transcription factors and other DNA binding proteins to access DNA, which has consequences for gene expression. Understanding the roles of histones and transcription factors is critical in understanding the regulation of gene expression.

Using ChIP-seq analysis, it is possible to profile histone modifications and transcription factor binding genome-wide to understand the regulation of gene expression in disease or in response to a drug treatment. Diagenode’s Epigenomic Profiling Services offer a wide variety of chromatin analysis options through ChIP-seq and ATAC-seq.


ATAC-seq: closed/open chromatin regions

Study genome-wide chromatin accessibility. Identify open chromatin sites and active regulatory elements such as promoter, enhancers, and insulators.

    • Nucleosome positioning
    • TF footprinting inference

ChIP-seq/ChIP-qPCR histone modifications on 10,000 cells

Post-translational modification of histones is implicated in the regulation of gene expression, necessitating the study of regulatory elements and their interacting proteins like active promoter and enhancer analysis. Profile genome-wide histone modifications by ChIP-seq analysis to understand transcriptional regulation

  • Active promoter profiling: H3K4me3 enrichment
  • Inactive promoter profiling: H3K27me3 enrichment
  • Enhancer profiling: H3K4me1 and H3K27ac enrichment in regulatory regions
  • Active gene body: H3K36me3

ChIP-seq/ChIP-qPCR Transcription Factors

Explore the effects of transcription factor binding through ChIP-seq analysis of a multitude of TFs including:

  • CTCF: transcriptional repressor and insulator activity
  • p300/CBP: histone acetyltransferase
  • Pol II, p53, and more
  • Epigenetic writers, readers, erasers
  • Nuclear receptors
  • Tumor suppressor genes

Custom NGS services

  • Low input libraries from picograms
  • Specific analyses
  • Complete customized project


Cat. No.ProductFormatPrice
G02110000 Single-Cell ATAC-seq Services
Assessing the genome-wide chromatin accessibility from individual cells provides unique insights of gene expression regulation for a number of fields such ...
G02060000 ATAC-seq service (Assay for Transposase-Accessible Chromatin)
ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) allows for assessing genome-wide chromatin accessibility. The technology is based on...
G02010000 ChIP-seq/ChIP-qPCR Profiling service
Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a powerful method allowing the genome-wide identification of DNA binding sites for pro...
G02100000 Bioinformatics Data Mining Service
New! Data mining using machine learning (AI) for unique epigenetic data insights Watch the webinar to gain insights on how data mining can be applied ...

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