Diagenode

Toxicology

Epigenetics in environmental toxicology

The fact that environmental factors induce DNA mutations that may lead to disease is well-established and will have tremendous benefits when incorporated into various environmental safety and health assessments. Environmental factors such as dietary intake, drugs, stress, or exposure to toxins, can cause epigenetic changes by possibly altering how transcription factors bind to DNA or changing the structure of the histones that DNA wraps around. These structural changes can affect gene activity or gene expression. A number of environmental factors have been investigated for their effect on epigenetic changes including phthalates, toxic metals, smoking, air pollution, jet fuel, environmental stress, and a high fat diet. Effects on epigenetic mechanisms, DNA methylation patterns, histone modifications, miRNA expression have been documented as a result. The table below (Marczylo et al, 2016 and Society of Toxicology, 2018) summarizes a few of the studies that have been done for putative environmentally-induced epigenetic toxicity in humans or rat/mouse.

In the future, incorporating epigenetic evaluation into toxicity tests can increase the safety of both food and environmental substances.

Toxin/exposureSpecies/stage of exposure/effectPhenotypeEpigenetic changeReference(s)
Air pollutionHuman/childhood/childhoodAsthmaEpigenetic mechanismsSomineni et al. (2016)
BPAHuman/in utero/childhoodBehaviorDNA methylationKundakovic (2015)
FormaldehydeHuman/lifetime/adultAlzheimer’sEpigenetic mechanisms and DNA methylationTong et al. (2015)
MethylmercuryRodent/in utero/adultBehaviorHistone modifications and DNA methylationOnishchenko (2008)
ArsenicHuman/lifetime/adultSkin disorderDNA methylationPaul et al. (2014)
NickelHuman/lifetime/adultNSCLC survivalmiRNAChiou et al. (2015)
Polycyclic aromatic hydrocarbonsHuman/adult/adultChromosome aberrations - PBLDNA methylationYang et al. (2012)
Various phthalatesRodent/in utero/adultDecreased testosterone/gonadalDNA methylation and histone modificationsKilcoyne et al. (2014) Martinez-Arguelles et al. (2009), Papoutsis et al. (2015), Takeda et al. (2012), Yoshioka et al. (2011)
SmokingHuman/Lifetime/adultCOPD and tumorEpigenetic mechanisms, DNA methylation, miRNALin (2010), Ostrow (2013) Shenker (2013), Xie et al. (2014)
AlcoholRodent/lifetime and in uteroNuerological, cardiac, behavior, stem cellHistone modification and miRNAIgnacio et al. (2014), Middleton et al. (2012), Leu et al. (2014), Pascual et al. (2011), Peng et al. (2015)
High fat dietRodent/in utero/adultDiet preferenceDNA methylation and miRNAsBaselga-Escudero (2015), Carlin et al. (2013), Vucetic et al. (2010)
Under-nourishmentRodent/adult/adultHepaticmiRNAsTryndyak et al. (2016)

Features for Toxicology

  • MagMeDIP-seq Package
    C02010040
    MagMeDIP-seq Package

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