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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1425 publications found×
Sensitive and reproducible cell-free methylome quantification with synthetic spike-in controls
Published: April, 2021
Abstract: Background. Cell-free methylated DNA immunoprecipitation-sequencing (cfMeDIP-seq) identifies genomic regions with DNA methylation, using a protocol adapted to work with low-input DNA samples and with cell-free DNA (cfDNA). This method allows for D...
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Antibody
Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis.
Published: April, 2021
Abstract: Acetylation of lysine 16 on histone H4 (H4K16ac) is catalyzed by histone acetyltransferase KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in Drosophila, the functions of H4K16ac and two KAT8-containing protei...
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Antibody
The anti-inflammatory cytokine interleukin-37 is an inhibitor of trainedimmunity.
Published: April, 2021
Abstract: Trained immunity (TI) is a de facto innate immune memory program induced in monocytes/macrophages by exposure to pathogens or vaccines, which evolved as protection against infections. TI is characterized by immunometabolic changes and histone post...
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Antibody
Dynamic association of the H3K64 trimethylation mark with genes encodingexported proteins in Plasmodium falciparum.
Published: April, 2021
Abstract: Epigenetic modifications have emerged as critical regulators of virulence genes and stage-specific gene expression in Plasmodium falciparum. However, the specific roles of histone core epigenetic modifications in regulating the stage-specific gene...
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Antibody
Chd8 regulates X chromosome inactivation in mouse through fine-tuningcontrol of Xist expression.
Published: April, 2021
Abstract: Female mammals achieve dosage compensation by inactivating one of their two X chromosomes during development, a process entirely dependent on Xist, an X-linked long non-coding RNA (lncRNA). At the onset of X chromosome inactivation (XCI), Xist is ...
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Antibody
Comparative analysis of histone H3K4me3 modifications between blastocystsand somatic tissues in cattle.
Published: April, 2021
Abstract: Epigenetic changes induced in the early developmental stages by the surrounding environment can have not only short-term but also long-term consequences throughout life. This concept constitutes the "Developmental Origins of Health and Disease" (D...
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Antibody
Genetic perturbation of PU.1 binding and chromatin looping at neutrophilenhancers associates with autoimmune disease.
Published: April, 2021
Abstract: Neutrophils play fundamental roles in innate immune response, shape adaptive immunity, and are a potentially causal cell type underpinning genetic associations with immune system traits and diseases. Here, we profile the binding of myeloid master ...
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Antibody
Epigenomic landscape of human colorectal cancer unveils an aberrant core ofpan-cancer enhancers orchestrated by YAP/TAZ.
Published: April, 2021
Abstract: Cancer is characterized by pervasive epigenetic alterations with enhancer dysfunction orchestrating the aberrant cancer transcriptional programs and transcriptional dependencies. Here, we epigenetically characterize human colorectal cancer (CRC) u...
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Antibody
Polycomb Repressive Complex 2 and KRYPTONITE regulate pathogen-inducedprogrammed cell death in Arabidopsis.
Published: April, 2021
Abstract: The Polycomb Repressive Complex 2 (PRC2) is well-known for its role in controlling developmental transitions by suppressing the premature expression of key developmental regulators. Previous work revealed that PRC2 also controls the onset of senes...
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Antibody Microplex Library Preparation kit
Fra-1 regulates its target genes via binding to remote enhancers withoutexerting major control on chromatin architecture in triple negative breastcancers.
Published: March, 2021
Abstract: The ubiquitous family of dimeric transcription factors AP-1 is made up of Fos and Jun family proteins. It has long been thought to operate principally at gene promoters and how it controls transcription is still ill-understood. The Fos family prot...
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Antibody
Loss of SETD1B results in the redistribution of genomic H3K4me3 in theoocyte
Published: March, 2021
Abstract: Histone 3 lysine 4 trimethylation (H3K4me3) is an epigenetic mark found at gene promoters and CpG islands. H3K4me3 is essential for mammalian development, yet mechanisms underlying its genomic targeting are poorly understood. H3K4me3 methyltransfe...
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Antibody Microplex Library Preparation kit
Cell-specific alterations inPitx1regulatory landscape activation caused bythe loss of a single enhancer
Published: March, 2021
Abstract: Most developmental genes rely on multiple transcriptional enhancers for their accurate expression during embryogenesis. Because enhancers may have partially redundant activities, the loss of one of them often leads to a partial loss of gene expres...
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Antibody
Transgenic mice for in vivo epigenome editing with CRISPR-based systems
Published: March, 2021
Abstract: The discovery, characterization, and adaptation of the RNA-guided clustered regularly interspersed short palindromic repeat (CRISPR)-Cas9 system has greatly increased the ease with which genome and epigenome editing can be performed. Fusion of chr...
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Antibody CRISPR
Unique Patterns of H3K4me3 and H3K27me3 in 2-Cell-like Embryonic StemCells.
Published: March, 2021
Abstract: A small subgroup of embryonic stem cells (ESCs) exhibit molecular features similar to those of two-cell embryos (2C). However, it remains elusive whether 2C-like cells and 2C embryos share similar epigenetic features. Here, we map the genome-wide ...
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Epigenomic tensor predicts disease subtypes and reveals constrained tumorevolution.
Published: March, 2021
Abstract: Understanding the epigenomic evolution and specificity of disease subtypes from complex patient data remains a major biomedical problem. We here present DeCET (decomposition and classification of epigenomic tensors), an integrative computational a...
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Antibody
Transcriptional programming drives Ibrutinib-resistance evolution in mantlecell lymphoma.
Published: March, 2021
Abstract: Ibrutinib, a bruton's tyrosine kinase (BTK) inhibitor, provokes robust clinical responses in aggressive mantle cell lymphoma (MCL), yet many patients relapse with lethal Ibrutinib-resistant (IR) disease. Here, using genomic, chemical proteomic, an...
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A regulatory variant at 3q21.1 confers an increased pleiotropic risk forhyperglycemia and altered bone mineral density.
Published: March, 2021
Abstract: Skeletal and glycemic traits have shared etiology, but the underlying genetic factors remain largely unknown. To identify genetic loci that may have pleiotropic effects, we studied Genome-wide association studies (GWASs) for bone mineral density a...
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Antibody
Functional annotations of three domestic animal genomes provide vitalresources for comparative and agricultural research.
Published: March, 2021
Abstract: Gene regulatory elements are central drivers of phenotypic variation and thus of critical importance towards understanding the genetics of complex traits. The Functional Annotation of Animal Genomes consortium was formed to collaboratively annotat...
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Antibody iDeal ChIP-seq Kit for Histones
Histone modification dynamics at H3K27 are associated with alteredtranscription of in planta induced genes in Magnaporthe oryzae.
Published: February, 2021
Abstract: Transcriptional dynamic in response to environmental and developmental cues are fundamental to biology, yet many mechanistic aspects are poorly understood. One such example is fungal plant pathogens, which use secreted proteins and small molecules...
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Antibody IPure kit
The histone modification H3K4me3 is altered at the locus in Alzheimer'sdisease brain.
Published: February, 2021
Abstract: Several epigenome-wide association studies of DNA methylation have highlighted altered DNA methylation in the gene in Alzheimer's disease (AD) brain samples. However, no study has specifically examined histone modifications in the disease. We use ...
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Antibody
REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERICMODULATOR
Published: February, 2021
Abstract: Canonical targeting of Polycomb Repressive Complex 1 (PRC1) to repress developmental genes is mediated by cell type-specific, paralogous chromobox (CBX) proteins (CBX2, 4, 6, 7 and 8). Based on their central role in silencing and their misregulati...
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Antibody
Germline activity of the heat shock factor HSF-1 programs theinsulin-receptor daf-2 in C. elegans
Published: February, 2021
Abstract: The mechanisms by which maternal stress alters offspring phenotypes remain poorly understood. Here we report that the heat shock transcription factor HSF-1, activated in the C. elegans maternal germline upon stress, epigenetically programs the ins...
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The G2-phase enriched lncRNA SNHG26 is necessary for proper cell cycleprogression and proliferation
Published: February, 2021
Abstract: Long noncoding RNAs (lncRNAs) are involved in the regulation of cell cycle, although only a few have been functionally characterized. By combining RNA sequencing and ChIP sequencing of cell cycle synchronized HaCaT cells we have previously identif...
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Antibody
STAG proteins promote cohesin ring loading at R-loops
Published: February, 2021
Abstract: Most studies of cohesin function consider the Stromalin Antigen (STAG/SA) proteins as core complex members given their ubiquitous interaction with the cohesin ring. Here, we provide functional data to support the notion that the SA subunit is not ...
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Restricted nucleation and piRNA-mediated establishment of heterochromatinduring embryogenesis in Drosophila miranda
Published: February, 2021
Abstract: Heterochromatin is a key architectural feature of eukaryotic genomes, crucial for silencing of repetitive elements and maintaining genome stability. Heterochromatin shows stereotypical enrichment patterns around centromeres and repetitive sequence...
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The epigenetic landscape in purified myonuclei from fast and slow muscles
Published: February, 2021
Abstract: Muscle cells have different phenotypes adapted to different usage and can be grossly divided into fast/glycolytic and slow/oxidative types. While most muscles contain a mixture of such fiber types, we aimed at providing a genome-wide analysis of c...
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Environmental enrichment induces epigenomic and genome organization changesrelevant for cognitive function
Published: February, 2021
Abstract: In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the epigenome and genome organ...
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Antibody
Chromatin dysregulation associated with NSD1 mutation in head and necksquamous cell carcinoma.
Published: February, 2021
Abstract: Chromatin dysregulation has emerged as an important mechanism of oncogenesis. To develop targeted treatments, it is important to understand the transcriptomic consequences of mutations in chromatin modifier genes. Recently, mutations in the histon...
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Antibody Bioruptor Plus IP-Star Compact
Kmt2c mutations enhance HSC self-renewal capacity and convey a selectiveadvantage after chemotherapy.
Published: February, 2021
Abstract: The myeloid tumor suppressor KMT2C is recurrently deleted in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), particularly therapy-related MDS/AML (t-MDS/t-AML), as part of larger chromosome 7 deletions. Here, we show that KMT2C de...
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Antibody
The glucocorticoid receptor recruits the COMPASS complex to regulateinflammatory transcription at macrophage enhancers.
Published: February, 2021
Abstract: Glucocorticoids (GCs) are effective anti-inflammatory drugs; yet, their mechanisms of action are poorly understood. GCs bind to the glucocorticoid receptor (GR), a ligand-gated transcription factor controlling gene expression in numerous cell type...
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Antibody

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