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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1425 publications found×
A leukemia-protective germline variant mediates chromatin moduleformation via transcription factor nucleation.
Published: April, 2022
Abstract: Non-coding variants coordinate transcription factor (TF) binding and chromatin mark enrichment changes over regions spanning >100 kb. These molecularly coordinated regions are named "variable chromatin modules" (VCMs), providing a concep...
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Antibody
Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing.
Published: April, 2022
Abstract: Precision epigenome editing has gained significant attention as a method to modulate gene expression without altering genetic information. However, a major limiting factor has been that the gene expression changes are often transient, unlike the l...
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Antibody
Broad domains of histone marks in the highly compact macronucleargenome.
Published: April, 2022
Abstract: The unicellular ciliate contains a large vegetative macronucleus with several unusual characteristics, including an extremely high coding density and high polyploidy. As macronculear chromatin is devoid of heterochromatin, our study characterizes ...
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Antibody iDeal ChIP-seq Kit for Histones
CREBBP/EP300 acetyltransferase inhibition disrupts FOXA1-bound enhancers to inhibit the proliferation of ER+ breast cancer cells.
Published: March, 2022
Abstract: Therapeutic targeting of the estrogen receptor (ER) is a clinically validated approach for estrogen receptor positive breast cancer (ER+ BC), but sustained response is limited by acquired resistance. Targeting the transcriptional coactivators requ...
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IP-Star Antibody Microplex Library Preparation kit iDeal ChIP-seq Kit for Histones Chromatin Profiling (ChIP-seq) Services
GBS-MeDIP: A protocol for parallel identification of genetic andepigenetic variation in the same reduced fraction of genomes acrossindividuals.
Published: March, 2022
Abstract: The GBS-MeDIP protocol combines two previously described techniques, Genotype-by-Sequencing (GBS) and Methylated-DNA-Immunoprecipitation (MeDIP). Our method allows for parallel and cost-efficient interrogation of genetic and methylomic variants in...
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Antibody
H3K9 dimethylation safeguards cancer cells against activation of theinterferon pathway.
Published: March, 2022
Abstract: Activation of interferon genes constitutes an important anticancer pathway able to restrict proliferation of cancer cells. Here, we demonstrate that the H3K9me3 histone methyltransferase (HMT) suppressor of variegation 3-9 homolog 1 (SUV39H1) is r...
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Evaluation of N6-adenine DNA-immunoprecipitation-basedgenomic profiling in eukaryotes
Published: March, 2022
Abstract: The detection of low-abundance DNA N6-methyladenine (DNA-m6A) remains challenging, limiting our understanding of this novel base in eukaryotes. To address this, we introduce an approach for systematically validating the selectivity and sensitivity...
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Preterm birth buccal cell epigenetic biomarkers to facilitatepreventative medicine.
Published: March, 2022
Abstract: Preterm birth is the major cause of newborn and infant mortality affecting nearly one in every ten live births. The current study was designed to develop an epigenetic biomarker for susceptibility of preterm birth using buccal cells from the mothe...
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Antibody
Avian influenza viruses suppress innate immunity by inducingtrans-transcriptional readthrough via SSU72.
Published: March, 2022
Abstract: Innate immunity plays critical antiviral roles. The highly virulent avian influenza viruses (AIVs) H5N1, H7N9, and H5N6 can better escape host innate immune responses than the less virulent seasonal H1N1 virus. Here, we report a mechanism by which...
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Antibody CRISPR
Regulation of paternal 5mC oxidation and H3K9me2 asymmetry byERK1/2 in mouse zygotes.
Published: March, 2022
Abstract: BACKGROUND: Extracellular-signal-regulated kinase (ERK) direct cell fate determination during the early development. The intricate interaction between the deposition of H3K9me2, de novo 5mC, and its oxides affects the remodeling of zygotic epigene...
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Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells.
Published: February, 2022
Abstract: The use of two inhibitors of Mek1/2 and Gsk3β (2i) promotes the generation of mouse diploid and haploid embryonic stem cells (ESCs) from the inner cell mass of biparental and uniparental blastocysts, respectively. However, a system enabling long-t...
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Antibody
Distinct effects on the secretion of MTRAP and AMA1 in Plasmodiumyoelii following deletion of acylated pleckstrin homology domain-containingprotein.
Published: February, 2022
Abstract: Plasmodium, the causative agents of malaria, are obligate intracellular organisms. In humans, pathogenesis is caused by the blood stage parasite, which multiplies within erythrocytes, thus erythrocyte invasion is an essential developmental step. M...
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Antisense non-coding transcription represses the PHO5 model genevia remodelling of promoter chromatin structure
Published: February, 2022
Abstract: Pervasive transcription of eukaryotic genomes generates non-coding transcripts with regulatory potential. We examined the effects of non-coding antisense transcription on the regulation of expression of the yeast PHO5 gene, a paradigmatic case for...
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Antibody CRISPR
Cell-type specific transcriptional networks in root xylem adjacent celllayers
Published: February, 2022
Abstract: Transport of water, ions and signals from roots to leaves via the xylem vessels is essential for plant life and needs to be tightly regulated. The final composition of the transpiration stream before passage into the shoots is controlled by the xy...
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Screening of ETO2-GLIS2-induced Super Enhancers identifiestargetable cooperative dependencies in acute megakaryoblastic leukemia.
Published: February, 2022
Abstract: Super Enhancers (SEs) are clusters of regulatory elements associated with cell identity and disease. However, whether these elements are induced by oncogenes and can regulate gene modules cooperating for cancer cell transformation or maintenance r...
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Antibody iDeal ChIP-seq Kit for Histones
Comprehensive characterization of the epigenetic landscape in Multiple Myeloma
Published: January, 2022
Abstract: Background: Human multiple myeloma (MM) cell lines (HMCLs) have been widely used to understand themolecular processes that drive MM biology. Epigenetic modifications are involved in MM development,progression, and drug resistance. A comprehensive ...
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Antibody Bioruptor Plus IPure kit IP-Star Compact
Comprehensive characterization of the epigenetic landscape in Multiple Myeloma
Published: January, 2022
Abstract: Background: Human multiple myeloma (MM) cell lines (HMCLs) have been widely used to understand the molecular processes that drive MM biology. Epigenetic modifications are involved in MM development, progression, and drug resistance. A comprehensiv...
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Bioruptor Antibody IP-Star Compact iDeal ChIP-seq Kit for Histones
Human centromere formation activates transcription and opens chromatinfibre structure
Published: January, 2022
Abstract: Human centromeres appear as constrictions on mitotic chromosomes and form a platform for kinetochore assembly in mitosis. Biophysical experiments led to a suggestion that repetitive DNA at centromeric regions form a compact scaffold necessary for ...
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Antibody
Pre-configuring chromatin architecture with histone modifications guideshematopoietic stem cell formation in mouse embryos.
Published: January, 2022
Abstract: The gene activity underlying cell differentiation is regulated by a diverse set of transcription factors (TFs), histone modifications, chromatin structures and more. Although definitive hematopoietic stem cells (HSCs) are known to emerge via endot...
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Antibody
NuA4 and H2A.Z control environmental responses and autotrophicgrowth in Arabidopsis
Published: January, 2022
Abstract: Nucleosomal acetyltransferase of H4 (NuA4) is an essential transcriptional coactivator in eukaryotes, but remains poorly characterized in plants. Here, we describe Arabidopsis homologs of the NuA4 scaffold proteins Enhancer of Polycomb-Like 1 (AtE...
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Antibody Microplex Library Preparation kit
DNMT1 regulates the timing of DNA methylation by DNMT3 in anenzymatic activity-dependent manner in mouse embryonic stem cells.
Published: January, 2022
Abstract: DNA methylation (DNAme; 5-methylcytosine, 5mC) plays an essential role in mammalian development, and the 5mC profile is regulated by a balance of opposing enzymatic activities: DNA methyltransferases (DNMTs) and Ten-eleven translocation dioxygenas...
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Antibody
Coordinated glucocorticoid receptor and MAFB action inducestolerogenesis and epigenome remodeling in dendritic cells
Published: January, 2022
Abstract: Abstract Glucocorticoids (GCs) exert potent anti-inflammatory effects in immune cells through the glucocorticoid receptor (GR). Dendritic cells (DCs), central actors for coordinating immune responses, acquire tolerogenic properties in response to ...
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Antibody IPure kit
Mod(mdg4) variants repress telomeric retrotransposon HeT-A byblocking subtelomeric enhancers
Published: January, 2022
Abstract: Telomeres in Drosophila are composed of sequential non-LTR retrotransposons: HeT-A, TART , and TAHRE . Although they are repressed by the piRNA pathway in the germline, how these retrotransposons are regulated in somatic cells is poorly understood...
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Antibody
Loss of KMT2C reprograms the epigenomic landscape in hPSCsresulting in NODAL overexpression and a failure of hemogenic endotheliumspecification.
Published: January, 2022
Abstract: Germline or somatic variation in the family of KMT2 lysine methyltransferases have been associated with a variety of congenital disorders and cancers. Notably, -fusions are prevalent in 70\% of infant leukaemias but fail to phenocopy short latency...
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Antibody
Stella regulates the Development of Female Germline Stem Cells byModulating Chromatin Structure and DNA Methylation.
Published: January, 2022
Abstract: Female germline stem cells (FGSCs) have the ability to self-renew and differentiate into oocytes. , encoded by a maternal effect gene, plays an important role in oogenesis and early embryonic development. However, its function in FGSCs remains unc...
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MagMeDIP kit Antibody
Effects of GSK-J4 on JMJD3 Histone Demethylase in MouseProstate Cancer Xenografts.
Published: January, 2022
Abstract: BACKGROUND/AIM: Histone methylation status is required to control gene expression. H3K27me3 is an epigenetic tri-methylation modification to histone H3 controlled by the demethylase JMJD3. JMJD3 is dysregulated in a wide range of cancers and has b...
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Bioruptor Antibody iDeal ChIP-seq Kit for Histones
Single amino-acid mutation in a Drosoph ila melanogaster ribosomalprotein: An insight in uL11 transcriptional activity.
Published: January, 2022
Abstract: The ribosomal protein uL11 is located at the basis of the ribosome P-stalk and plays a paramount role in translational efficiency. In addition, no mutant for uL11 is available suggesting that this gene is haplo-insufficient as many other Ribosomal...
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Antibody
Chemokine switch regulated by TGF-β1 in cancer-associated fibroblastsubsets determines the efficacy of chemo-immunotherapy.
Published: January, 2022
Abstract: Combining immunogenic cell death-inducing chemotherapies and PD-1 blockade can generate remarkable tumor responses. It is now well established that TGF-β1 signaling is a major component of treatment resistance and contributes to the cancer-re...
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Antibody IP-Star Compact
27-Hydroxycholesterol, The Estrogen Receptor Modulator, AltersDNA Methylation in Breast Cancer.
Published: January, 2022
Abstract: 27-hydroxycholesterol (27-HC) is the first known endogenous selective estrogen receptor modulator (SERM), and its elevation from normal levels is closely associated with breast cancer. A plethora of evidence suggests that aberrant epigenetic signa...
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Antibody
Androgen receptor and MYC equilibration centralizes on developmentalsuper-enhancer
Published: December, 2021
Abstract: Androgen receptor (AR) in prostate cancer (PCa) can drive transcriptional repression of multiple genes including MYC, and supraphysiological androgen is effective in some patients. Here, we show that this repression is independent of AR chromatin ...
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Antibody

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