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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
Monitoring autochthonous lung tumors induced by somatic CRISPR geneediting in mice using a secreted luciferase.
Published: October, 2022
Abstract: BACKGROUND: In vivo gene editing of somatic cells with CRISPR nucleases has facilitated the generation of autochthonous mouse tumors, which are initiated by genetic alterations relevant to the human disease and progress along a natural timeline as...
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Antibody CRISPR
Trained Immunity Provides Long-Term Protection againstBacterial Infections in Channel Catfish.
Published: October, 2022
Abstract: Beta glucan exposure induced trained immunity in channel catfish that conferred long-term protection against and infections one month post exposure. Flow cytometric analyses demonstrated that isolated macrophages and neutrophils phagocytosed highe...
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Antibody
Linked-read whole-genome sequencing resolves common and privatestructural variants in multiple myeloma.
Published: September, 2022
Abstract: Multiple myeloma (MM) is an incurable and aggressive plasma cell malignancy characterized by a complex karyotype with multiple structural variants (SVs) and copy-number variations (CNVs). Linked-read whole-genome sequencing (lrWGS) allows for refi...
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Antibody
Repression and 3D-restructuring resolves regulatory conflicts inevolutionarily rearranged genomes.
Published: September, 2022
Abstract: Regulatory landscapes drive complex developmental gene expression, but it remains unclear how their integrity is maintained when incorporating novel genes and functions during evolution. Here, we investigated how a placental mammal-specific gene, ...
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Antibody iDeal ChIP-seq Kit for Histones
Exploration of nuclear body-enhanced sumoylation reveals that PMLrepresses 2-cell features of embryonic stem cells.
Published: September, 2022
Abstract: Membrane-less organelles are condensates formed by phase separation whose functions often remain enigmatic. Upon oxidative stress, PML scaffolds Nuclear Bodies (NBs) to regulate senescence or metabolic adaptation. PML NBs recruit many partner prot...
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Bioruptor Antibody iDeal ChIP-qPCR
Dominant role of DNA methylation over H3K9me3 for IAP silencingin endoderm.
Published: September, 2022
Abstract: Silencing of endogenous retroviruses (ERVs) is largely mediated by repressive chromatin modifications H3K9me3 and DNA methylation. On ERVs, these modifications are mainly deposited by the histone methyltransferase Setdb1 and by the maintenance DNA...
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Antibody Microplex Library Preparation kit
A complex epigenome-splicing crosstalk governs epithelial-to-mesenchymaltransition in metastasis and brain development.
Published: August, 2022
Abstract: Epithelial-to-mesenchymal transition (EMT) renders epithelial cells migratory properties. While epigenetic and splicing changes have been implicated in EMT, the mechanisms governing their crosstalk remain poorly understood. Here we discovered that...
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Bioruptor Antibody
Vitamin D receptor and STAT6 interactome governs oesophagealepithelial barrier responses to IL-13 signalling.
Published: August, 2022
Abstract: OBJECTIVE: The contribution of vitamin D (VD) deficiency to the pathogenesis of allergic diseases remains elusive. We aimed to define the impact of VD on oesophageal allergic inflammation. DESIGN: We assessed the genomic distribution and function ...
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Antibody IP-Star Compact
Histone demethylase KDM2A suppresses EGF-TSPAN8 pathway toinhibit breast cancer cell migration and invasion in vitro.
Published: August, 2022
Abstract: Metastasis is a major cause of breast cancer mortality and the current study found histone demethylase, KDM2A, expression to be negatively correlated with breast cancer metastasis. KDM2A knockdown greatly promoted migration and invasion of breast ...
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Antibody
Distinct silencer states generate epigenetic states of heterochromatin.
Published: August, 2022
Abstract: Heterochromatic loci can exhibit different transcriptional states in genetically identical cells. A popular model posits that the inheritance of modified histones is sufficient for inheritance of the silenced state. However, silencing inheritance ...
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Antibody
bESCs from cloned embryos do not retain transcriptomic or epigenetic memory from somatic donor cells.
Published: August, 2022
Abstract: Embryonic stem cells (ESC) indefinitely maintain the pluripotent state of the blastocyst epiblast. Stem cells are invaluable for studying development and lineage commitment, and in livestock they constitute a useful tool for genomic improvement an...
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Antibody
Histone lysine demethylase inhibition reprograms prostate cancermetabolism and mechanics.
Published: August, 2022
Abstract: OBJECTIVE: Aberrant activity of androgen receptor (AR) is the primary cause underlying development and progression of prostate cancer (PCa) and castration-resistant PCa (CRPC). Androgen signaling regulates gene transcription and lipid metabolism, ...
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Antibody Bioruptor Plus
The Arabidopsis APOLO and human UPAT sequence-unrelated longnoncoding RNAs can modulate DNA and histone methylation machineries inplants.
Published: August, 2022
Abstract: BACKGROUND: RNA-DNA hybrid (R-loop)-associated long noncoding RNAs (lncRNAs), including the Arabidopsis lncRNA AUXIN-REGULATED PROMOTER LOOP (APOLO), are emerging as important regulators of three-dimensional chromatin conformation and gene transcr...
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Bioruptor Antibody
Histone H3K36me2 and H3K36me3 form a chromatin platform essentialfor DNMT3A-dependent DNA methylation in mouse oocytes.
Published: August, 2022
Abstract: Establishment of the DNA methylation landscape of mammalian oocytes, mediated by the DNMT3A-DNMT3L complex, is crucial for reproduction and development. In mouse oocytes, high levels of DNA methylation occur exclusively in the transcriptionally ac...
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Antibody
Epigenetic remodeling of downstream enhancer regions is linked toselective expression of the IL1F10 gene in differentiated humankeratinocytes.
Published: August, 2022
Abstract: Interleukin (IL)-38, encoded by the IL1F10 gene, is a member of the IL-1 family of cytokines. IL-38 is constitutively expressed in epithelia in healthy humans, and in particular in epidermal keratinocytes in the skin. IL-38 expression is closely c...
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Antibody iDeal ChIP-qPCR
Prolonged FOS activity disrupts a global myogenic transcriptionalprogram by altering 3D chromatin architecture in primary muscleprogenitor cells.
Published: August, 2022
Abstract: BACKGROUND: The AP-1 transcription factor, FBJ osteosarcoma oncogene (FOS), is induced in adult muscle satellite cells (SCs) within hours following muscle damage and is required for effective stem cell activation and muscle repair. However, why FO...
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Bioruptor Antibody iDeal ChIP-qPCR
Large-scale manipulation of promoter DNA methylation revealscontext-specific transcriptional responses and stability.
Published: July, 2022
Abstract: BACKGROUND: Cytosine DNA methylation is widely described as a transcriptional repressive mark with the capacity to silence promoters. Epigenome engineering techniques enable direct testing of the effect of induced DNA methylation on endogenous pro...
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Antibody
HOTAIR interacts with PRC2 complex regulating the regional preadipocytetranscriptome and human fat distribution.
Published: July, 2022
Abstract: Mechanisms governing regional human adipose tissue (AT) development remain undefined. Here, we show that the long non-coding RNA HOTAIR (HOX transcript antisense RNA) is exclusively expressed in gluteofemoral AT, where it is essential for adipocyt...
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Antibody
Embryonic heat conditioning in chicks induces transgenerationalheat/immunological resilience via methylation on regulatory elements.
Published: July, 2022
Abstract: The question of whether behavioral traits are heritable is under debate. An obstacle in demonstrating transgenerational inheritance in mammals originates from the maternal environment's effect on offspring phenotype. Here, we used in ovo embryonic...
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Antibody
Epiblast inducers capture mouse trophectoderm stem cells in vitro andpattern blastoids for implantation in utero.
Published: July, 2022
Abstract: The embryo instructs the allocation of cell states to spatially regulate functions. In the blastocyst, patterning of trophoblast (TR) cells ensures successful implantation and placental development. Here, we defined an optimal set of molecules sec...
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Antibody
Nox4 promotes endothelial differentiation through chromatin remodeling.
Published: July, 2022
Abstract: RATIONALE: Nox4 is a constitutively active NADPH oxidase that constantly produces low levels of HO. Thereby, Nox4 contributes to cell homeostasis and long-term processes, such as differentiation. The high expression of Nox4 seen in endothelial cel...
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Antibody
Systematic comparison of CRISPR-based transcriptional activatorsuncovers gene-regulatory features of enhancer-promoter interactions.
Published: July, 2022
Abstract: Nuclease-inactivated CRISPR/Cas-based (dCas-based) systems have emerged as powerful technologies to synthetically reshape the human epigenome and gene expression. Despite the increasing adoption of these platforms, their relative potencies and mec...
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Antibody CRISPR
Epigenomic analysis reveals a dynamic and context-specific macrophageenhancer landscape associated with innate immune activation and tolerance.
Published: June, 2022
Abstract: BACKGROUND: Chromatin states and enhancers associate gene expression, cell identity and disease. Here, we systematically delineate the acute innate immune response to endotoxin in terms of human macrophage enhancer activity and contrast with endot...
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Antibody
Nuclear receptor RORγ inverse agonists/antagonists display tissue- andgene-context selectivity through distinct activities in altering chromatinaccessibility and master regulator SREBP2 occupancy.
Published: June, 2022
Abstract: The nuclear receptor RORγ is a major driver of autoimmune diseases and certain types of cancer due to its aberrant function in T helper 17 (Th17) cell differentiation and tumor cholesterol metabolism, respectively. Compound screening using t...
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Antibody
HISTONE DEACETYLASE 15 and MOS4-Associated Complex subunits3A/3B coregulate intron retention of ABA-responsive genes.
Published: June, 2022
Abstract: Histone deacetylases (HDAs) play an important role in transcriptional regulation of multiple biological processes. In this study, we investigated the function of HDA15 in abscisic acid (ABA) responses. We used immunopurification coupled with mass ...
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Antibody
NSUN2-mediated RNA mC modification modulates uveal melanoma cellproliferation and migration.
Published: June, 2022
Abstract: RNA 5-methylcytosine (mC) is a widespread post-transcriptional modification involved in diverse biological processes through controlling RNA metabolism. However, its roles in uveal melanoma (UM) remain unknown. Here, we describe the biological rol...
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Antibody
Caffeine intake exerts dual genome-wide effects on hippocampal metabolismand learning-dependent transcription.
Published: June, 2022
Abstract: Caffeine is the most widely consumed psychoactive substance in the world. Strikingly, the molecular pathways engaged by its regular consumption remain unclear. We herein addressed the mechanisms associated with habitual (chronic) caffeine consumpt...
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Antibody Microplex Library Preparation kit CUT&Tag
EHF is a novel regulator of cellular redox metabolism and predictspatient prognosis in HNSCC.
Published: June, 2022
Abstract: Head and Neck Squamous Cell Carcinoma (HNSCC) is a heterogeneous disease with relatively high morbidity and mortality rates. The lack of effective therapies, high recurrence rates and drug resistance driven in part, by tumor heterogeneity, contrib...
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Chromatin Shearing Antibody
Effects of GSK-J4 on JMJD3 Histone Demethylase in Mouse Prostate Cancer Xenografts
Published: May, 2022
Abstract: Background/aim: Histone methylation status is required to control gene expression. H3K27me3 is an epigenetic tri-methylation modification to histone H3 controlled by the demethylase JMJD3. JMJD3 is dysregulated in a wide range of cancers and ...
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Antibody IP-Star Compact iDeal ChIP-seq Kit for Histones
Epigenetic Mechanisms Mediating Cell State Transitions in Chondrocytes
Published: May, 2022
Abstract: Epigenetic modifications play critical roles in regulating cell lineage differentiation, but the epigenetic mechanisms guiding specific differentiation steps within a cell lineage have rarely been investigated. To decipher such mechanisms, we used...
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Bioruptor Antibody Microplex Library Preparation kit True MicroChIP kit

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  • QMUL Centre for Epigenetics Launch Conference 2025
    London, UK
    Jun 4, 2025
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