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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1425 publications found×
Epiblast inducers capture mouse trophectoderm stem cells in vitro andpattern blastoids for implantation in utero.
Published: July, 2022
Abstract: The embryo instructs the allocation of cell states to spatially regulate functions. In the blastocyst, patterning of trophoblast (TR) cells ensures successful implantation and placental development. Here, we defined an optimal set of molecules sec...
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Antibody
Nox4 promotes endothelial differentiation through chromatin remodeling.
Published: July, 2022
Abstract: RATIONALE: Nox4 is a constitutively active NADPH oxidase that constantly produces low levels of HO. Thereby, Nox4 contributes to cell homeostasis and long-term processes, such as differentiation. The high expression of Nox4 seen in endothelial cel...
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Antibody
Systematic comparison of CRISPR-based transcriptional activatorsuncovers gene-regulatory features of enhancer-promoter interactions.
Published: July, 2022
Abstract: Nuclease-inactivated CRISPR/Cas-based (dCas-based) systems have emerged as powerful technologies to synthetically reshape the human epigenome and gene expression. Despite the increasing adoption of these platforms, their relative potencies and mec...
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Antibody CRISPR
Epigenomic analysis reveals a dynamic and context-specific macrophageenhancer landscape associated with innate immune activation and tolerance.
Published: June, 2022
Abstract: BACKGROUND: Chromatin states and enhancers associate gene expression, cell identity and disease. Here, we systematically delineate the acute innate immune response to endotoxin in terms of human macrophage enhancer activity and contrast with endot...
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Antibody
Nuclear receptor RORγ inverse agonists/antagonists display tissue- andgene-context selectivity through distinct activities in altering chromatinaccessibility and master regulator SREBP2 occupancy.
Published: June, 2022
Abstract: The nuclear receptor RORγ is a major driver of autoimmune diseases and certain types of cancer due to its aberrant function in T helper 17 (Th17) cell differentiation and tumor cholesterol metabolism, respectively. Compound screening using t...
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Antibody
HISTONE DEACETYLASE 15 and MOS4-Associated Complex subunits3A/3B coregulate intron retention of ABA-responsive genes.
Published: June, 2022
Abstract: Histone deacetylases (HDAs) play an important role in transcriptional regulation of multiple biological processes. In this study, we investigated the function of HDA15 in abscisic acid (ABA) responses. We used immunopurification coupled with mass ...
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Antibody
NSUN2-mediated RNA mC modification modulates uveal melanoma cellproliferation and migration.
Published: June, 2022
Abstract: RNA 5-methylcytosine (mC) is a widespread post-transcriptional modification involved in diverse biological processes through controlling RNA metabolism. However, its roles in uveal melanoma (UM) remain unknown. Here, we describe the biological rol...
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Antibody
Caffeine intake exerts dual genome-wide effects on hippocampal metabolismand learning-dependent transcription.
Published: June, 2022
Abstract: Caffeine is the most widely consumed psychoactive substance in the world. Strikingly, the molecular pathways engaged by its regular consumption remain unclear. We herein addressed the mechanisms associated with habitual (chronic) caffeine consumpt...
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Antibody Microplex Library Preparation kit CUT&Tag
EHF is a novel regulator of cellular redox metabolism and predictspatient prognosis in HNSCC.
Published: June, 2022
Abstract: Head and Neck Squamous Cell Carcinoma (HNSCC) is a heterogeneous disease with relatively high morbidity and mortality rates. The lack of effective therapies, high recurrence rates and drug resistance driven in part, by tumor heterogeneity, contrib...
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Chromatin Shearing Antibody
Effects of GSK-J4 on JMJD3 Histone Demethylase in Mouse Prostate Cancer Xenografts
Published: May, 2022
Abstract: Background/aim: Histone methylation status is required to control gene expression. H3K27me3 is an epigenetic tri-methylation modification to histone H3 controlled by the demethylase JMJD3. JMJD3 is dysregulated in a wide range of cancers and ...
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Antibody IP-Star Compact iDeal ChIP-seq Kit for Histones
Epigenetic Mechanisms Mediating Cell State Transitions in Chondrocytes
Published: May, 2022
Abstract: Epigenetic modifications play critical roles in regulating cell lineage differentiation, but the epigenetic mechanisms guiding specific differentiation steps within a cell lineage have rarely been investigated. To decipher such mechanisms, we used...
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Bioruptor Antibody Microplex Library Preparation kit True MicroChIP kit
Global DNA methylation and cellular 5-methylcytosine and H4acetylated patterns in primary and secondary dormant seeds of Capsellabursa-pastoris (L.) Medik. (shepherd's purse).
Published: May, 2022
Abstract: Despite the importance of dormancy and dormancy cycling for plants' fitness and life cycle phenology, a comprehensive characterization of the global and cellular epigenetic patterns across space and time in different seed dormancy states is lackin...
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Antibody
TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p incolorectal cancer.
Published: May, 2022
Abstract: The Telomeric Repeat binding Factor 2 (TRF2), a key protein involved in telomere integrity, is over-expressed in several human cancers and promotes tumor formation and progression. Recently, TRF2 has been also found outside telomeres where it can ...
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Antibody
Developmental mRNA mC landscape and regulatory innovations of massivemC modification of maternal mRNAs in animals.
Published: May, 2022
Abstract: mC is one of the longest-known RNA modifications, however, its developmental dynamics, functions, and evolution in mRNAs remain largely unknown. Here, we generate quantitative mRNA mC maps at different stages of development in 6 vertebrate and inv...
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Antibody
HIRA supports hepatitis B virus minichromosome establishment andtranscriptional activity in infected hepatocytes.
Published: May, 2022
Abstract: BACKGROUND \& AIMS: Upon Hepatitis B virus (HBV) infection, partially double stranded viral DNA converts into a covalently-closed-circular chromatinized episomal structure (cccDNA). This form represents the long-lived genomic reservoir respons...
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Antibody
Novel role of UHRF1 in the epigenetic repression of the latent HIV-1.
Published: May, 2022
Abstract: BACKGROUND: The multiplicity, heterogeneity, and dynamic nature of human immunodeficiency virus type-1 (HIV-1) latency mechanisms are reflected in the current lack of functional cure for HIV-1. Accordingly, all classes of latency-reversing agents ...
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Antibody
MiR-129-5p exerts Wnt signaling-dependent tumor-suppressive functionsin hepatocellular carcinoma by directly targeting hepatoma-derived growthfactor HDGF.
Published: May, 2022
Abstract: BACKGROUND: In hepatocellular carcinoma (HCC), histone deacetylases (HDACs) are frequently overexpressed. This results in chromatin compaction and silencing of tumor-relevant genes and microRNAs. Modulation of microRNA expression is a potential tr...
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Antibody
PHF13 epigenetically activates TGFβ driven epithelial to mesenchymaltransition
Published: May, 2022
Abstract: Epigenetic alteration is a pivotal factor in tumor metastasis. PHD finger protein 13 (PHF13) is a recently identified epigenetic reader of H3K4me2/3 that functions as a transcriptional co-regulator. In this study, we demonstrate that PHF13 is requ...
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Antibody
Variation in PU.1 binding and chromatin looping at neutrophil enhancersinfluences autoimmune disease susceptibility
Published: May, 2022
Abstract: Neutrophils play fundamental roles in innate inflammatory response, shape adaptive immunity1, and have been identified as a potentially causal cell type underpinning genetic associations with immune system traits and diseases2,3 The majority of th...
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Antibody
Macrophage programming is regulated by a cooperative interaction betweenfatty acid binding protein 5 and peroxisome proliferator-activated receptorγ.
Published: May, 2022
Abstract: Resolution of inflammation is an active process that is tightly regulated to achieve repair and tissue homeostasis. In the absence of resolution, persistent inflammation underlies the pathogenesis of chronic lung disease such as chronic obstructiv...
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Antibody
AUXIN RESPONSE FACTOR 16 (StARF16) regulates defense gene StNPR1 upon infection with necrotrophic pathogen in potato.
Published: April, 2022
Abstract: We demonstrate a new regulatory mechanism in the jasmonic acid (JA) and salicylic acid (SA) mediated crosstalk in potato defense response, wherein, miR160 target StARF16 (a gene involved in growth and development) binds to the promoter of StNPR1 (...
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Antibody Universal Plant ChIP-seq Kit
ACTL6a coordinates axonal caliber recognition and myelination in theperipheral nerve.
Published: April, 2022
Abstract: Cells elaborate transcriptional programs in response to external signals. In the peripheral nerves, Schwann cells (SC) sort axons of given caliber and start the process of wrapping their membrane around them. We identify Actin-like protein 6a (ACT...
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Antibody
The CpG Island-Binding Protein SAMD1 Contributes to anUnfavorable Gene Signature in HepG2 Hepatocellular CarcinomaCells.
Published: April, 2022
Abstract: The unmethylated CpG island-binding protein SAMD1 is upregulated in many human cancer types, but its cancer-related role has not yet been investigated. Here, we used the hepatocellular carcinoma cell line HepG2 as a cancer model and investigated t...
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Bioruptor Antibody Microplex Library Preparation kit
MLL-AF4 and a murinized pSer-variant thereof are turning on thenucleolar stress pathway.
Published: April, 2022
Abstract: BACKGROUND: Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoietic stem/progenitor cells (...
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Bioruptor Antibody
Assessment of TET1 gene expression, DNA methylation and H3K27me3level of its promoter region in eutopic endometrium of women withendometriosis and infertility.
Published: April, 2022
Abstract: Endometriosis is the cause of infertility. The eutopic endometrium of women with endometriosis showed an aberrant expression pattern of multitude genes. The role of TET1 protein in the pathogenesis of endometriosis and related infertility is not s...
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Chromatin Shearing Antibody
Local euchromatin enrichment in lamina-associated domains anticipatestheir repositioning in the adipogenic lineage.
Published: April, 2022
Abstract: BACKGROUND: Interactions of chromatin with the nuclear lamina via lamina-associated domains (LADs) confer structural stability to the genome. The dynamics of positioning of LADs during differentiation, and how LADs impinge on developmental gene ex...
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Antibody Microplex Library Preparation kit
ZWC complex-mediated SPT5 phosphorylation suppresses divergentantisense RNA transcription at active gene promoters.
Published: April, 2022
Abstract: The human genome encodes large numbers of non-coding RNAs, including divergent antisense transcripts at transcription start sites (TSSs). However, molecular mechanisms by which divergent antisense transcription is regulated have not been detailed....
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Antibody
Immune disease variants modulate gene expression in regulatory CD4T cells.
Published: April, 2022
Abstract: Identifying cellular functions dysregulated by disease-associated variants could implicate novel pathways for drug targeting or modulation in cell therapies. However, follow-up studies can be challenging if disease-relevant cell types are difficul...
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Antibody iDeal ChIP-seq Kit for Histones
SMYD5 is a histone H3-specific methyltransferase mediatingmono-methylation of histone H3 lysine 36 and 37.
Published: April, 2022
Abstract: Although post-translational modifications (-PTMs) of some histone H3 lysine residues are well studied, the PTMs of histone H3 lysine 37 in mammalian cells remain largely unknown. In this study, we provide evidence to show that SMYD family member 5...
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Antibody
Environmental induced transgenerational inheritance impacts systemsepigenetics in disease etiology.
Published: April, 2022
Abstract: Environmental toxicants have been shown to promote the epigenetic transgenerational inheritance of disease through exposure specific epigenetic alterations in the germline. The current study examines the actions of hydrocarbon jet fuel, dioxin, pe...
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Antibody

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