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Cancer

Epigenetics and Cancer

Epigenetic processes control the normal development and maintenance of gene expression in a number of organisms. However, disruption of epigenetic mechanisms may alter gene function, potentially leading to cellular transformations that lead to tumorigenesis. Cancer is a multistep process from a succession of processes that alter the growth of normal cells. In cancer, epigenetic reprogramming occurs at multiple levels including nuclear organization and nucleosome positioning, DNA methylation, modification of histones, alteration of epigenetic regulators such as transcription factor binding, and non-coding RNA, such as microRNA.

Epigenetic modifications are reversible and potential treatments could be geared to alter irregular transcription factor binding, DNA methylation or histone acetylation. Accurate study with a versatile number of tools is essential for the study of epigenetics including sound sample preparation and analysis methodologies for DNA methylation such as with immunoprecipitation or bisulfite sequencing, chromatin analysis with chromatin immunoprecipitation (ChIP) combined with qPCR or sequencing, and RNA modification study. As researchers elucidate the mechanisms and specific modifications associated with cancer, it may be possible to target abnormal modifications in cells with minimal damage to normal cells, making the prospect of epigenetic therapy increasingly promising.

Diagenode products for your epigenomics research in Cancer

Chromatin analysis

Understand the role of chromatin in cancer regulation

DNA methylation

Analyze DNA methylation and the effects on oncogenesis and tumor suppression

Non-coding RNAs

Discover noncoding RNAs in cancer

Features for Cancer

  • Illumina index primers for D-Plex small RNA library preparation with UMI
    C05030010
    D-Plex 24 Single Indexes for Illumina - Set #A
  • Illumina index primers for D-Plex small RNA library preparation with UMI
    C05030011
    D-Plex 24 Single Indexes for Illumina - Set #B
  • Illumina index primers for D-Plex small RNA library preparation with UMI
    C05030021
    D-Plex Unique Dual Indexes for Illumina - Set A
  • Illumina index primers for D-Plex small RNA library preparation with UMI
    C05030022
    D-Plex Unique Dual Indexes for Illumina - Set B
  • default alt
    C02010041
    MagMeDIP-seq Pacakge V2
  • default alt
    C05010024
    iDeal DNA IP Library Preparation Kit
  • default alt
    C05010025
    iDeal Unique Dual Indexes for Illumina - Set A ...
  • MagMeDIP-seq Package
    C02010040
    MagMeDIP-seq Package

活动

  • ChIP workshop
    Diagenode
    Sep 21-Sep 22, 2021
  • DNA methylation workshop: Master MeDIP assay
    Diagenode
    Sep 30, 2021
  • DNA methylation workshop: Become an expert at RRBS
    Diagenode
    Oct 1-Oct 31, 2021
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新闻

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