A rapid micro chromatin immunoprecipitation assay (microChIP). Published: January, 2008 Abstract:
Interactions of proteins with DNA mediate many critical nuclear functions. Chromatin immunoprecipitation (ChIP) is a robust technique for studying protein-DNA interactions. Current ChIP assays, however, either require large cell numbers, which pre... Read more » Tags Antibody
Reciprocal regulation of p63 by C/EBP delta in human keratinocytes. Published: January, 2007 Abstract:
BACKGROUND: Genetic experiments have clarified that p63 is a key transcription factor governing the establishment and maintenance of multilayered epithelia. Key to our understanding of p63 strategy is the identification of target genes. We perfome... Read more » Tags Antibody
A self-inactivating system for AAV-mediated in vivo base editing Abstract:
DNA base editors have been harnessed as an exciting therapeutic platform for human diseases and are rapidly progressing into human clinical trials. However, persistent expression of base editors delivered via adeno-associated virus (AAV) poses con... Read more » Tags AntibodyCRISPR
PRAME induces genomic instability in uveal melanoma Abstract:
PRAME is a CUL2 ubiquitin ligase subunit that is normally expressed in the testis but becomes aberrantly overexpressed in many cancer types in association with aneuploidy and metastasis. Here, we show that PRAME is expressed predominantly in sperm... Read more » Tags Antibody
