CDK8/19 Mediator kinases potentiate induction of transcription by NFκB Published: September, 2017 Abstract:
The nuclear factor-κB (NFκB) family of transcription factors has been implicated in inflammatory disorders, viral infections, and cancer. Most of the drugs that inhibit NFκB show significant side effects, possibly due to sustaine... Read more » Tags Antibody
Epigenetic variation between urban and rural populations of Darwin's finches Published: August, 2017 Abstract:
Background
The molecular basis of evolutionary change is assumed to be genetic variation. However, growing evidence suggests that epigenetic mechanisms, such as DNA methylation, may also be involved in rapid adaptation to new environments. An... Read more » Tags Antibody
Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging Published: August, 2017 Abstract:
The process of aging and circadian rhythms are intimately intertwined, but how peripheral clocks involved in metabolic homeostasis contribute to aging remains unknown. Importantly, caloric restriction (CR) extends lifespan in several organisms and... Read more » Tags Antibody
Chromatin Immunoprecipitation (ChIP) in Mouse T-cell Lines Published: June, 2017 Abstract:
Signaling pathways regulate gene expression programs via the modulation of the chromatin structure at different levels, such as by post-translational modifications (PTMs) of histone tails, the exchange of canonical histones with histone variants, ... Read more » Tags Antibody
