Publications

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1524 publications found×

Endurance training increases a ubiquitylated form of histone H3 in the skeletal muscle, supporting Notch1 upregulation in an MDM2-dependent manner
Published: September, 2025

Abstract: At the onset of training, each exercise session transiently shifts the distribution of histone post-transcriptional modifications (HPTMs) to activate genes that drive muscle adaptations. The resulting cyclic changes in gene expression promote th...
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Antibody

Profiling BRCA1-BRCT interactions and their functional relevance at amino acid resolution
Published: September, 2025

Abstract: BRCA1 (breast cancer-associated protein 1) plays a central role in homologous recombination (HR) through interactions with multiple proteins across its various domains. The C-terminal BRCT domains bind HR regulators such as ABRAXAS1, CtIP, and...
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Antibody

Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation
Published: August, 2025

Abstract: Comprehensive epigenomic studies in multiple myeloma (MM) that unravel the connections between major epigenetic regulators, their intertwined collaboration and the potential of combinatorial targeting remain limited. Utilizing ChIP-seq, ATAC-seq, ...
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Antibody iDeal ChIP-seq Kit for Histones

De novo assembly and delivery of synthetic megabase-scale human DNA into mouse early embryos
Published: August, 2025

Abstract: Epigenetic modifications on natural chromosomes are inherited and maintained in a default state, making it challenging to remove intrinsic marks to study the fundamental principles of their establishment and further influence on transcriptiona...
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Antibody

Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation
Published: August, 2025

Abstract: The lysine-specific demethylase 1 (LSD1) regulates hematopoietic stem cell differentiation and has been identified as a therapeutic target in hematological disorders. LSD1 demethylates mono and dimethylated histones 3 at lysine 4 and 9. In add...
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Active chromatin marks and up-regulation of FOXC1 in uterine epithelial cells demarcate the onset of reproductive decline in aging females
Published: August, 2025

Abstract: Advanced maternal age increases the risk of pregnancy complications due, in part, to changes in the uterine environment. Here, we show that uterine aging in mice is associated with a progressive increase in transcriptional variation, accompanied...
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Antibody Microplex Library Preparation kit

H3K27me3-mediated epigenetic regulation of TET1 in the eutopic endometrium of women with endometriosis and infertility
Published: August, 2025

Abstract: Endometriosis is a common gynecological condition associated with chronic inflammation, epigenetic dysregulation, and infertility. The TET1 gene, involved in DNA demethylation, may be regulated by repressive histone modifications such as H3K27me...
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Antibody

Evidence of neuronal DNA damage in the brains of patients with Rett syndrome
Published: August, 2025

Abstract: Rett syndrome is characterized by the postnatal loss of neurophysiological function and regression of childhood development. Because the syndrome is X linked, and males with MECP2 mutations generally do not survive birth, the study of this syndr...
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Antibody

SUMO operates from a unique long tandem repeat to keep innate immunity in check
Published: July, 2025

Abstract: The SUMO pathway mainly functions to repress innate immunity in myeloid cells. Inactivating sumoylation triggers a strong, noncanonical, type I interferon (IFN1) response, amplified and coupled with inflammation upon stimulation. These finding...
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Antibody Microplex Library Preparation kit

Somatic mutations in TBX3 promote hepatic clonal expansion by accelerating VLDL secretion
Published: July, 2025

Abstract: Somatic mutations that increase clone fitness or resist disease are positively selected, but the impact of these mutations on organismal health remains unclear. We previously showed that Tbx3 deletion increases hepatocyte fitness within fatty li...
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Traditional Chinese Medicine Luo Tong Formula attenuates retinal injury in experimental diabetic retinopathy via modulation of DNA methylation: in vivo experiment integrated with molecular docking, ADMET assessment, and molecular dynamics simulation
Published: July, 2025

Abstract: Background: Diabetic retinopathy (DR) is a leading cause of blindness in the adult population. Luo-Tong Formula (LTF), a traditional Chinese medicine prescription, has been frequently employed in the treatment of DR. However, the ability of LTF to...
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Antibody

Liebenberg syndrome severity arises from variations in Pitx1 locus topology and proportion of ectopically transcribing cells
Published: July, 2025

Abstract: Enhancer hijacking, a common cause of gene misregulation linked to disease, occurs when non-matching enhancers and promoters interact ectopically due to genetic alterations. While the concept of enhancer hijacking is well understood, the reaso...
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Antibody

Dissecting the epigenetic regulation of the fetal hemoglobin genes to unravel a novel therapeutic approach for β-hemoglobinopathies
Published: July, 2025

Abstract: Beta-hemoglobinopathies are severe genetic diseases caused by mutations affecting the production of the adult β-globin chain. The clinical severity is mitigated by the co-inheritance of mutations that reactivate the production of the feta...
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Antibody

Constitutive expression of the transcriptional co-activator IκBζ promotes melanoma growth and immunotherapy resistance
Published: June, 2025

Abstract: IκBζ, a rather unknown co-regulator of NF-κB, can either activate or repress a subset of NF-κB target genes. While its role as an inducibly expressed, transcriptional regulator of cytokines and chemokines in immune cells...
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Antibody

Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells
Published: June, 2025

Abstract: Iron is an irreplaceable co-factor for metabolism. Iron deficiency affects >1 billion people and decreased iron availability impairs immunity. Nevertheless, how iron deprivation impacts immune cell function remains poorly characterised. We ...
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Antibody

Extrusion fountains are restricted by WAPL-dependent cohesin release and CTCF barriers
Published: June, 2025

Abstract: Interphase chromosomes are mainly shaped by loop extrusion and compartmentalisation mechanisms. However, their temporal component and cause-effect relationships remain largely unknown. In this study, we use acute degradation of WAPL, CTCF and ...
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A spatially organized Cd24a+/ Pax9+ stem cell core governs postnatal tooth establishment
Published: June, 2025

Abstract: Mineralized tissues are fundamental in mechanical support and protection in vertebrates. Their formation by progenitor cells during development remains elusive. Here, we show that the postnatal establishment of the molar teeth was governed by ...
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Antibody

Epigenetic responses in Borrelia-infected Ixodes scapularis ticks: Over-expression of euchromatic histone lysine methyltransferase 2 and no change in DNA methylation
Published: June, 2025

Abstract: Borrelia burgdorferi, a tick-vectored spirochete bacteria best known for causing Lyme disease, has been found to induce physiological and behavioural changes in its tick vector that can increase tick fitness and its ability to transmit the bac...
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MagMeDIP kit Antibody

Charting the regulatory landscape of TP53 on transposable elements in cancer
Published: May, 2025

Abstract: The relationship between TP53 and transposable elements (TEs) has been obscure. Given the important role of TEs in oncogenesis, a comprehensive profiling of TE expression dynamics under the regulation of TP53 provides valuable resources for more c...
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Antibody iDeal ChIP-seq Kit for Transcription Factors

Epstein-Barr Virus-Driven B-Cell Transformation under Germinal Center Hypoxia Requires External Unsaturated Fatty Acids
Published: April, 2025

Abstract: Epstein-Barr virus (EBV) contributes to over 200,000 cancers annually, predominantly aggressive lymphomas originating from hypoxic germinal centers (< 1% O2). However, conventional models fail to recapitulate the physiologically relevant hypoxi...
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Antibody iDeal ChIP-seq Kit for Histones

The establishment of nuclear organization in mouse embryos is orchestrated by multiple epigenetic pathways
Published: April, 2025

Abstract: The folding of the genome in the 3D nuclear space is fundamental for regulating all DNA-related processes. The association of the genome with the nuclear lamina into lamina-associated domains (LADs) represents the earliest feature of nuclear org...
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Antibody CUT&Tag

HSV-1 infection induces a downstream shift of the +1 nucleosome
Published: March, 2025

Abstract: Herpes simplex virus 1 (HSV-1) infection induces a loss of host transcriptional activity and widespread disruption of host transcription termination, which leads to an induction of open chromatin downstream of genes. In this study, we show that ly...
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Antibody

Plasma cell-free DNA chromatin immunoprecipitation profiling depicts phenotypic and clinical heterogeneity in advanced prostate cancer
Published: February, 2025

Abstract: Cell phenotype underlies prostate cancer presentation and treatment resistance and can be regulated by epigenomic features. However, the osteotropic tendency of prostate cancer limits access to metastatic tissue, meaning most prior insights into p...
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Antibody

CRISPR screening identifies regulators of enhancer-mediated androgen receptor transcription in advanced prostate cancer
Published: February, 2025

Abstract: Amplification of the androgen receptor (AR) locus is the most frequent alteration in metastatic castration-resistant prostate cancer (CRPC). Recently, it was discovered that an enhancer of the AR is co-amplified with the AR gene body and c...
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Antibody ATAC-seq

Accelerated epigenetic aging in Huntington’s disease involves polycomb repressive complex 1
Published: February, 2025

Abstract: Loss of epigenetic information during physiological aging compromises cellular identity, leading to de-repression of developmental genes. Here, we assessed the epigenomic landscape of vulnerable neurons in two reference mouse models of Huntington ...
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Antibody Microplex Library Preparation kit CUT&Tag

Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome
Published: February, 2025

Abstract: The placental DNA methylation landscape is unique, with widespread partially methylated domains (PMDs). The placental "methylome" is conserved across mammals, a shared feature of many cancers, and extensively studied for links with pregnancy com...
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Antibody Microplex Library Preparation kit

Trithorax regulates long-term memory in Drosophila through epigenetic maintenance of mushroom body metabolic state and translation capacity
Published: January, 2025

Abstract: The role of epigenetics and chromatin in the maintenance of postmitotic neuronal cell identities is not well understood. Here, we show that the histone methyltransferase Trithorax (Trx) is required in postmitotic memory neurons of the Drosoph...
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Antibody Microplex Library Preparation kit True MicroChIP kit

Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow
Published: January, 2025

Abstract: Highlights Gut barrier disruption induces trained immunity in bone marrow progenitors Enterococcus faecalis translocates to the bone marrow, inducing trained immunity Mincle sensing of E. faecalis m...
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Antibody CUT&Tag

Motif distribution and DNA methylation underlie distinct Cdx2 binding during development and homeostasis
Published: January, 2025

Abstract: Transcription factors guide tissue development by binding to developmental stage-specific targets and establishing an appropriate enhancer landscape. In turn, DNA and chromatin modifications direct the genomic binding of transcription factors. How...
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Antibody

The senolytic cocktail, dasatinib and quercetin, impacts the chromatin structure of both young and senescent vascular smooth muscle cells
Published: January, 2025

Abstract: One promising strategy to alleviate aging symptoms is the treatment with senolytics that is compounds which selectively eliminate senescent cells. Some therapies aim to reduce symptoms of cellular senescence without senescent cell eradication (sen...
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