Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1524 publications found×

PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions.
Published: May, 2021

Abstract: Group 2 innate lymphoid cells (ILC2s) play a critical role in protection against helminths and in diverse inflammatory diseases by responding to soluble factors such as the alarmin IL-33, that is often overexpressed in cancer. Nonetheless, regulat...
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Identification of a PadR-type regulator essential for intracellularpathogenesis of
Published: May, 2021

Abstract: Burkholderia pseudomallei (Bp) is the causative agent of melioidosis, a disease endemic to the tropics. Melioidosis manifests in various ways ranging from acute skin lesions to pneumonia and, in rare cases, infection of the central nervous system....
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Epigenomic profiling of primate lymphoblastoid cell lines reveals theevolutionary patterns of epigenetic activities in gene regulatoryarchitectures
Published: May, 2021

Abstract: Changes in the epigenetic regulation of gene expression have a central role in evolution. Here, we extensively profiled a panel of human, chimpanzee, gorilla, orangutan, and macaque lymphoblastoid cell lines (LCLs), using ChIP-seq for five histone...
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GATA6 defines endoderm fate by controlling chromatin accessibility duringdifferentiation of human-induced pluripotent stem cells
Published: May, 2021

Abstract: SUMMARY In addition to driving specific gene expression profiles, transcriptional regulators are becoming increasingly recognized for their capacity to modulate chromatin structure. GATA6 is essential for the formation of definitive endoderm; howe...
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The SAM domain-containing protein 1 (SAMD1) acts as a repressivechromatin regulator at unmethylated CpG islands
Published: May, 2021

Abstract: CpG islands (CGIs) are key regulatory DNA elements at most promoters, but how they influence the chromatin status and transcription remains elusive. Here, we identify and characterize SAMD1 (SAM domain-containing protein 1) as an unmethylated CGI-...
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Antibody Microplex Library Preparation kit

MeCP2 controls neural stem cell fate specification throughmiR-199a-mediated inhibition of BMP-Smad signaling.
Published: May, 2021

Abstract: Rett syndrome (RTT) is a severe neurological disorder, with impaired brain development caused by mutations in MECP2; however, the underlying mechanism remains elusive. We know from previous work that MeCP2 facilitates the processing of a specific ...
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Simplification of culture conditions and feeder-free expansion of bovineembryonic stem cells
Published: May, 2021

Abstract: Bovine embryonic stem cells (bESCs) extend the lifespan of the transient pluripotent bovine inner cell mass in vitro. After years of research, derivation of stable bESCs was only recently reported. Although successful, bESC culture relies on compl...
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Androgen and glucocorticoid receptor direct distinct transcriptionalprograms by receptor-specific and shared DNA binding sites.
Published: April, 2021

Abstract: The glucocorticoid (GR) and androgen (AR) receptors execute unique functions in vivo, yet have nearly identical DNA binding specificities. To identify mechanisms that facilitate functional diversification among these transcription factor paralogs,...
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USP22 Suppresses Expression in Acute Colitis and Inflammation-AssociatedColorectal Cancer.
Published: April, 2021

Abstract: As a member of the 11-gene "death-from-cancer" gene expression signature, ubiquitin-specific protease 22 (USP22) has been considered an oncogene in various human malignancies, including colorectal cancer (CRC). We recently identified an unexpected...
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Sensitive and reproducible cell-free methylome quantification with synthetic spike-in controls
Published: April, 2021

Abstract: Background. Cell-free methylated DNA immunoprecipitation-sequencing (cfMeDIP-seq) identifies genomic regions with DNA methylation, using a protocol adapted to work with low-input DNA samples and with cell-free DNA (cfDNA). This method allows for D...
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Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis.
Published: April, 2021

Abstract: Acetylation of lysine 16 on histone H4 (H4K16ac) is catalyzed by histone acetyltransferase KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in Drosophila, the functions of H4K16ac and two KAT8-containing protei...
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The anti-inflammatory cytokine interleukin-37 is an inhibitor of trainedimmunity.
Published: April, 2021

Abstract: Trained immunity (TI) is a de facto innate immune memory program induced in monocytes/macrophages by exposure to pathogens or vaccines, which evolved as protection against infections. TI is characterized by immunometabolic changes and histone post...
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Dynamic association of the H3K64 trimethylation mark with genes encodingexported proteins in Plasmodium falciparum.
Published: April, 2021

Abstract: Epigenetic modifications have emerged as critical regulators of virulence genes and stage-specific gene expression in Plasmodium falciparum. However, the specific roles of histone core epigenetic modifications in regulating the stage-specific gene...
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Chd8 regulates X chromosome inactivation in mouse through fine-tuningcontrol of Xist expression.
Published: April, 2021

Abstract: Female mammals achieve dosage compensation by inactivating one of their two X chromosomes during development, a process entirely dependent on Xist, an X-linked long non-coding RNA (lncRNA). At the onset of X chromosome inactivation (XCI), Xist is ...
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Comparative analysis of histone H3K4me3 modifications between blastocystsand somatic tissues in cattle.
Published: April, 2021

Abstract: Epigenetic changes induced in the early developmental stages by the surrounding environment can have not only short-term but also long-term consequences throughout life. This concept constitutes the "Developmental Origins of Health and Disease" (D...
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Genetic perturbation of PU.1 binding and chromatin looping at neutrophilenhancers associates with autoimmune disease.
Published: April, 2021

Abstract: Neutrophils play fundamental roles in innate immune response, shape adaptive immunity, and are a potentially causal cell type underpinning genetic associations with immune system traits and diseases. Here, we profile the binding of myeloid master ...
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Epigenomic landscape of human colorectal cancer unveils an aberrant core ofpan-cancer enhancers orchestrated by YAP/TAZ.
Published: April, 2021

Abstract: Cancer is characterized by pervasive epigenetic alterations with enhancer dysfunction orchestrating the aberrant cancer transcriptional programs and transcriptional dependencies. Here, we epigenetically characterize human colorectal cancer (CRC) u...
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Polycomb Repressive Complex 2 and KRYPTONITE regulate pathogen-inducedprogrammed cell death in Arabidopsis.
Published: April, 2021

Abstract: The Polycomb Repressive Complex 2 (PRC2) is well-known for its role in controlling developmental transitions by suppressing the premature expression of key developmental regulators. Previous work revealed that PRC2 also controls the onset of senes...
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Antibody Microplex Library Preparation kit

Fra-1 regulates its target genes via binding to remote enhancers withoutexerting major control on chromatin architecture in triple negative breastcancers.
Published: March, 2021

Abstract: The ubiquitous family of dimeric transcription factors AP-1 is made up of Fos and Jun family proteins. It has long been thought to operate principally at gene promoters and how it controls transcription is still ill-understood. The Fos family prot...
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Loss of SETD1B results in the redistribution of genomic H3K4me3 in theoocyte
Published: March, 2021

Abstract: Histone 3 lysine 4 trimethylation (H3K4me3) is an epigenetic mark found at gene promoters and CpG islands. H3K4me3 is essential for mammalian development, yet mechanisms underlying its genomic targeting are poorly understood. H3K4me3 methyltransfe...
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Antibody Microplex Library Preparation kit

Cell-specific alterations inPitx1regulatory landscape activation caused bythe loss of a single enhancer
Published: March, 2021

Abstract: Most developmental genes rely on multiple transcriptional enhancers for their accurate expression during embryogenesis. Because enhancers may have partially redundant activities, the loss of one of them often leads to a partial loss of gene expres...
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Transgenic mice for in vivo epigenome editing with CRISPR-based systems
Published: March, 2021

Abstract: The discovery, characterization, and adaptation of the RNA-guided clustered regularly interspersed short palindromic repeat (CRISPR)-Cas9 system has greatly increased the ease with which genome and epigenome editing can be performed. Fusion of chr...
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Unique Patterns of H3K4me3 and H3K27me3 in 2-Cell-like Embryonic StemCells.
Published: March, 2021

Abstract: A small subgroup of embryonic stem cells (ESCs) exhibit molecular features similar to those of two-cell embryos (2C). However, it remains elusive whether 2C-like cells and 2C embryos share similar epigenetic features. Here, we map the genome-wide ...
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Epigenomic tensor predicts disease subtypes and reveals constrained tumorevolution.
Published: March, 2021

Abstract: Understanding the epigenomic evolution and specificity of disease subtypes from complex patient data remains a major biomedical problem. We here present DeCET (decomposition and classification of epigenomic tensors), an integrative computational a...
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Transcriptional programming drives Ibrutinib-resistance evolution in mantlecell lymphoma.
Published: March, 2021

Abstract: Ibrutinib, a bruton's tyrosine kinase (BTK) inhibitor, provokes robust clinical responses in aggressive mantle cell lymphoma (MCL), yet many patients relapse with lethal Ibrutinib-resistant (IR) disease. Here, using genomic, chemical proteomic, an...
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A regulatory variant at 3q21.1 confers an increased pleiotropic risk forhyperglycemia and altered bone mineral density.
Published: March, 2021

Abstract: Skeletal and glycemic traits have shared etiology, but the underlying genetic factors remain largely unknown. To identify genetic loci that may have pleiotropic effects, we studied Genome-wide association studies (GWASs) for bone mineral density a...
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Functional annotations of three domestic animal genomes provide vitalresources for comparative and agricultural research.
Published: March, 2021

Abstract: Gene regulatory elements are central drivers of phenotypic variation and thus of critical importance towards understanding the genetics of complex traits. The Functional Annotation of Animal Genomes consortium was formed to collaboratively annotat...
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Antibody iDeal ChIP-seq Kit for Histones

Histone modification dynamics at H3K27 are associated with alteredtranscription of in planta induced genes in Magnaporthe oryzae.
Published: February, 2021

Abstract: Transcriptional dynamic in response to environmental and developmental cues are fundamental to biology, yet many mechanistic aspects are poorly understood. One such example is fungal plant pathogens, which use secreted proteins and small molecules...
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Antibody IPure kit

The histone modification H3K4me3 is altered at the locus in Alzheimer'sdisease brain.
Published: February, 2021

Abstract: Several epigenome-wide association studies of DNA methylation have highlighted altered DNA methylation in the gene in Alzheimer's disease (AD) brain samples. However, no study has specifically examined histone modifications in the disease. We use ...
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REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERICMODULATOR
Published: February, 2021

Abstract: Canonical targeting of Polycomb Repressive Complex 1 (PRC1) to repress developmental genes is mediated by cell type-specific, paralogous chromobox (CBX) proteins (CBX2, 4, 6, 7 and 8). Based on their central role in silencing and their misregulati...
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