The 20S proteasome activator PA28γ controls the compaction of chromatin Published: May, 2020 Abstract:
The nuclear PA28γ is known to activate the 20S proteasome, but its precise cellular functions remains unclear. Here, we identify PA28γ as a key factor that structures heterochromatin. We find that in human cells, a fraction of PA28&gam... Read more » Tags Antibody
Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer. Published: April, 2020 Abstract:
The functional consequences of somatic non-coding mutations in ovarian cancer (OC) are unknown. To identify regulatory elements (RE) and genes perturbed by acquired non-coding variants, here we establish epigenomic and transcriptomic landscapes of... Read more » Tags Antibody
An epigenetic map of malaria parasite development from host to vector. Published: April, 2020 Abstract:
The malaria parasite replicates asexually in the red blood cells of its vertebrate host employing epigenetic mechanisms to regulate gene expression in response to changes in its environment. We used chromatin immunoprecipitation followed by sequen... Read more » Tags Antibody
Abo1 is required for the H3K9me2 to H3K9me3 transition in heterochromatin. Published: April, 2020 Abstract:
Heterochromatin regulation is critical for genomic stability. Different H3K9 methylation states have been discovered, with distinct roles in heterochromatin formation and silencing. However, how the transition from H3K9me2 to H3K9me3 is controlled... Read more » Tags Antibody
