Diagenode

Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

CRISPR/Cas9-mediated inactivation of miR-34a and miR-34b/c inHCT116...
Published: July, 2023

Abstract: The miR-34a and miR-34b/c encoding genes represent direct targets of the p53 transcription factor, and presumably mediate part of the tumor suppres... Read more »

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iDeal ChIP-qPCR
Perturbed epigenetic transcriptional regulation in AML with IDHmuta...
Published: July, 2023

Abstract: Isocitrate dehydrogenase (IDH) mutations are found in 20\% of acute myeloid leukemia (AML) patients. However, only 30-40\% of the patients respond ... Read more »

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Infinium Human MethylationEPIC Array Service
Carnobacterium maltaromaticum boosts intestinal vitamin D productio...
Published: July, 2023

Abstract: Carnobacterium maltaromaticum was found to be specifically depleted in female patients with colorectal cancer (CRC). Administration of C.Â&nb... Read more »

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Antibody
Enhanced frequency of transcription pre-initiation complexes assemb...
Published: July, 2023

Abstract: In addition to being essential for gene expression, transcription is crucial for the maintenance of genome integrity. Here, we undertook a systemat... Read more »

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Antibody
ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic ac...
Published: July, 2023

Abstract: Poly (ADP-ribose) Polymerase (PARP) inhibitors (PARPi) have been approved for both frontline and recurrent setting in ovarian cancer with homologou... Read more »

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Antibody
Opposing gene regulatory programs governing myofiber development an...
Published: July, 2023

Abstract: Skeletal muscle fibers express distinct gene programs during development and maturation, but the underlying gene regulatory networks that confer st... Read more »

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Antibody
Alterations in the hepatocyte epigenetic landscape in steatosis.
Published: July, 2023

Abstract: Fatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk f... Read more »

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Antibody
SMYD3 represses tumor-intrinsic interferon response in HPV-negative...
Published: July, 2023

Abstract: Cancers often display immune escape, but the mechanisms are incompletely understood. Herein, we identify SMYD3 as a mediator of immune escape in hu... Read more »

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Antibody
DeSUMOylation of chromatin-bound proteins limits the rapidtranscrip...
Published: July, 2023

Abstract: Genotoxicants have been used for decades as front-line therapies against cancer on the basis of their DNA-damaging actions. However, some of their ... Read more »

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Antibody
RNA polymerase II CTD is dispensable for transcription and required...
Published: July, 2023

Abstract: The largest subunit of RNA polymerase (Pol) II harbors an evolutionarily conserved C-terminal domain (CTD), composed of heptapeptide repeats, centr... Read more »

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Antibody
Net39 protects muscle nuclei from mechanical stress during thepatho...
Published: July, 2023

Abstract: Mutations in genes encoding nuclear envelope proteins lead to diseases known as nuclear envelopathies, characterized by skeletal muscle and heart a... Read more »

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Antibody
Single-cell quantification of ribosome occupancy in early mouse dev...
Published: June, 2023

Abstract: Translation regulation is critical for early mammalian embryonic development1. However, previous studies had been restricted to bulk measurements2,... Read more »

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D-Plex small RNA-seq
The NF-Y splicing signature controls hybrid EMT and ECM-related pat...
Published: June, 2023

Abstract: Aberrant splicing events are associated with colorectal cancer (CRC) and provide new opportunities for tumor diagnosis and treatment. The expressio... Read more »

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Newly added
Targeting lymphoid-derived IL-17 signaling to delay skin aging.
Published: June, 2023

Abstract: Skin aging is characterized by structural and functional changes that contribute to age-associated frailty. This probably depends on synergy betwee... Read more »

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ChIP Cross-link Gold
Polycomb protein SCML2 mediates paternal epigenetic inheritance thr...
Published: June, 2023

Abstract: Sperm chromatin retains small amounts of histones, and chromatin states of sperm mirror gene expression programs of the next generation. However, i... Read more »

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Antibody
DIS3 ribonuclease prevents the cytoplasmic accumulation of lncRNAs ...
Published: June, 2023

Abstract: Around 12% of multiple myeloma (MM) cases harbour mutations in DIS3, which encodes an RNA decay enzyme that controls the turnover of some long... Read more »

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D-Plex small RNA-seq
Nicotinamide N-methyltransferase sustains a core epigenetic program...
Published: June, 2023

Abstract: Metastatic colonization of distant organs accounts for over 90% of deaths related to solid cancers, yet the molecular determinants of metastasis re... Read more »

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Antibody
SMYD3: a new regulator of the early steps of adipocyte differentiation
Published: June, 2023

Abstract: In obesity, adipose tissue undergoes a remodeling process characterized by increased adipocyte size (hypertrophia) and number (hyperplasia). The in... Read more »

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Antibody
Single-cell m6A mapping in vivo using picoMeRIP-seq
Published: June, 2023

Abstract: Current N-methyladenosine (mA) mapping methods need large amounts of RNA or are limited to cultured cells. Through optimized sample recovery and si... Read more »

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Antibody
NUP98 and RAE1 sustain progenitor function through HDAC-dependentch...
Published: June, 2023

Abstract: Self-renewing somatic tissues rely on progenitors to support the continuous tissue regeneration. The gene regulatory network maintaining progenitor... Read more »

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Antibody
Bioengineering novel AAV9-mGULO-GT for multi-disease gene therapy:T...
Published: June, 2023

Abstract: Current clinical breakthroughs in gene therapy have brought adeno-associated virus (AAV) vectors to the forefront of gene delivery systems. Vitamin... Read more »

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Antibody
Supraphysiological Androgens Promote the Tumor Suppressive Activity...
Published: June, 2023

Abstract: The androgen receptor (AR) pathway regulates key cell survival programs in prostate epithelium. The AR represents a near-universal driver and thera... Read more »

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Microplex Library Preparation kit iDeal ChIP-seq Kit for Transcription Factors
In skeletal muscle and neural crest cells, SMCHD1 regulates biologi...
Published: June, 2023

Abstract: Many genetic syndromes are linked to mutations in genes encoding factors that guide chromatin organization. Among them, several distinct rare genet... Read more »

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Antibody iDeal ChIP-seq Kit for Transcription Factors iDeal ChIP-seq Kit for Histones Infinium Human MethylationEPIC Array Service
Direct enzymatic sequencing of 5-methylcytosine at single-baseresol...
Published: June, 2023

Abstract: 5-methylcytosine (5mC) is the most important DNA modification in mammalian genomes. The ideal method for 5mC localization would be both nondestruct... Read more »

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Premium Bisulfite Kit
Vitamin D Receptor Cross-talk with p63 Signaling PromotesEpidermal ...
Published: June, 2023

Abstract: The vitamin D receptor with its ligand 1,25 dihydroxy vitamin D (1,25D) regulates epidermal stem cell fate, such that VDR removal from Krt14 expres... Read more »

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Antibody iDeal ChIP-seq Kit for Transcription Factors
Mu opioid receptor expressing neurons in the rostral ventromedial m...
Published: June, 2023

Abstract: Repeated exposure to psychophysical stress often causes an increase in sensitivity and response to pain. This phenomenon is commonly called stress-... Read more »

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Antibody
SALL1 enforces microglia-specific DNA binding and function of SMADs...
Published: June, 2023

Abstract: Spalt-like transcription factor 1 (SALL1) is a critical regulator of organogenesis and microglia identity. Here we demonstrate that disruption of a... Read more »

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Antibody
Sexual differentiation in human malaria parasites is regulated byco...
Published: June, 2023

Abstract: For Plasmodium falciparum, the most widespread and virulent malaria parasite that infects humans, persistence depends on continuous asexual replica... Read more »

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Antibody
Identification of a deltaNp63-Dependent Basal-Like ASubtype-Specifi...
Published: June, 2023

Abstract: A major hurdle to the application of precision oncology in pancreatic cancer is the lack of molecular stratification approaches and targeted therap... Read more »

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Antibody
Hypomethylation and overexpression of Th17-associated genes is ahal...
Published: June, 2023

Abstract: BACKGROUND: The development of Crohn's disease (CD) involves immune cell signaling pathways regulated by epigenetic modifications. Aberrant DNA met... Read more »

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Antibody Microplex Library Preparation kit

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