Publications,References

Epigenetic Networks Regulate the Transcriptional Program in Memory ...
Published: December, 2016

Abstract: Epigenetic mechanisms play a critical role during differentiation of T cells by contributing to the formation of stable and heritable transcription... Read more »

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ChIP-seq

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic ...
Published: December, 2016

Abstract: Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring ... Read more »

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Antibody

FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of ...
Published: December, 2016

Abstract: FOXA1 is a pioneer factor that binds to enhancer regions that are enriched in H3K4 mono- and dimethylation (H3K4me1 and H3K4me2). We performed a FO... Read more »

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Antibody

Immunometabolic Pathways in BCG-Induced Trained Immunity
Published: December, 2016

Abstract: The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on unrelated infections are thought to be mediated by long-term m... Read more »

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Antibody

A transcription factor pulse can prime chromatin for heritable tran...
Published: December, 2016

Abstract: Short-term and long-term transcriptional memory is the phenomenon whereby the kinetics or magnitude of gene induction is enhanced following a prior... Read more »

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Antibody

Distinct and Shared Determinants of Cardiomyocyte Contractility in ...
Published: December, 2016

Abstract: The realization of personalized medicine through human induced pluripotent stem cell (iPSC) technology can be advanced by transcriptomics, epigenom... Read more »

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Bioruptor IP-Star Compact

Potent and selective bivalent inhibitors of BET bromodomains
Published: December, 2016

Abstract: Proteins of the bromodomain and extraterminal (BET) family, in particular bromodomain-containing protein 4 (BRD4), are of great interest as biologi... Read more »

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Antibody

Lhx2 interacts with the NuRD complex and regulates cortical neuron ...
Published: December, 2016

Abstract: n the developing cerebral cortex, sequential transcriptional programs take neuroepithelial cells from proliferating progenitors to differentiated n... Read more »

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Antibody

Genomic Characterization of Metformin Hepatic Response
Published: November, 2016

Abstract: Metformin is used as a first-line therapy for type 2 diabetes (T2D) and prescribed for numerous other diseases. However, its mechanism of action in... Read more »

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LowCell ChIP kit IPure kit

ING1 regulates rRNA levels by altering nucleolar chromatin structur...
Published: November, 2016

Abstract: Epigenetic, transcriptional and signaling processes in the nucleolus regulate rRNA transcription and cell growth. We report here that the tumor sup... Read more »

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Antibody

Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk...
Published: November, 2016

Abstract: The Polycomb repressive complexes PRC1 and PRC2 play a central role in developmental gene regulation in multicellular organisms. PRC1 and PRC2 modi... Read more »

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Antibody

Gene regulatory networks in neural cell fate acquisition from genom...
Published: November, 2016

Abstract: Neural cell fate acquisition is mediated by transcription factors expressed in nascent neuroectoderm, including Geminin and members of the Zic tran... Read more »

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Antibody

Genome-wide epigenomic profiling for biomarker discovery
Published: November, 2016

Abstract: A myriad of diseases is caused or characterized by alteration of epigenetic patterns, including changes in DNA methylation, post-translational hist... Read more »

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IP-Star Compact

Genome-wide DNA methylation analysis identifies MEGF10 as a novel e...
Published: November, 2016

Abstract: Neuroblastoma is a childhood cancer in which many children still have poor outcomes, emphasising the need to better understand its pathogenesis. De... Read more »

TET-dependent regulation of retrotransposable elements in mouse emb...
Published: November, 2016

Abstract: BACKGROUND: Ten-eleven translocation (TET) enzymes oxidise DNA methylation as part of an active demethylation pathway. Despite extensive researc... Read more »

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Bioruptor Antibody

Genetic Drivers of Epigenetic and Transcriptional Variation in Huma...
Published: November, 2016

Abstract: Characterizing the multifaceted contribution of genetic and epigenetic factors to disease phenotypes is a major challenge in human genetics a... Read more »

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Antibody IP-Star Compact

β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological...
Published: November, 2016

Abstract: Innate immune memory is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure... Read more »

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Bioruptor Antibody

EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells
Published: November, 2016

Abstract: The cellular plasticity of pluripotent stem cells is thought to be sustained by genomic regions that display both active and repressive chromatin p... Read more »

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Bioruptor Antibody

Genome-wide DNA promoter methylation and transcriptome analysis in ...
Published: November, 2016

Abstract: Objective/methods DNA methylation plays an important role in obesity and related metabolic complications. We examined genome-wide DNA promoter met... Read more »

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Bioruptor MagMeDIP kit

The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-...
Published: November, 2016

Abstract: The t(8;21) acute myeloid leukemia (AML)-associated oncoprotein AML1-ETO disrupts normal hematopoietic differentiation. Here, we have investigated ... Read more »

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Bioruptor Antibody

Activation of GPER suppresses migration and angiogenesis of triple ...
Published: November, 2016

Abstract: Triple-negative breast cancer (TNBC) are characterized by high vascularity and frequent metastasis. Here, we found that activation of G protein-cou... Read more »

Reader domain specificity and lysine demethylase-4 family function
Published: November, 2016

Abstract: The KDM4 histone demethylases are conserved epigenetic regulators linked to development, spermatogenesis and tumorigenesis. However, how the KDM4 f... Read more »

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Antibody

Enhanced CRISPR/Cas9-mediated precise genome editing by improved de...
Published: November, 2016

Abstract: While CRISPR-based gene knock out in mammalian cells has proven to be very efficient, precise insertion of genetic elements via the cellular homolo... Read more »

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Antibody

Biphasic regulation of chondrocytes by Rela through induction of an...
Published: November, 2016

Abstract: In vitro studies have shown that Rela/p65, a key subunit mediating NF-κB signalling, is involved in chondrogenic differentiation, cell surviv... Read more »

TET2 binds the androgen receptor and loss is associated with prosta...
Published: November, 2016

Abstract: Genetic alterations associated with prostate cancer (PCa) may be identified by sequencing metastatic tumour genomes to identify molecular markers a... Read more »

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Antibody

A set of novel automated quantitative microproteomics protocols for...
Published: November, 2016

Abstract: Here we assessed the ability of an automated sample preparation device equipped with disposable microcolumns to prepare mass-limited samples for hi... Read more »

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Bioruptor Mass Spectrometry

Transcriptional Activation of Pericentromeric Satellite Repeats and...
Published: November, 2016

Abstract: Heterochromatinisation of pericentromeres, which in mice consist of arrays of major satellite repeats, are important for centromere formation and m... Read more »

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Bioruptor IPure kit

Chromatin Preparation and Chromatin Immuno-precipitation from Droso...
Published: November, 2016

Abstract: This protocol provides specific details on how to perform Chromatin immunoprecipitation (ChIP) from Drosophila embryos. ChIP allows the matching of... Read more »

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Antibody

Iterative Fragmentation Improves the Detection of ChIP-seq Peaks fo...
Published: October, 2016

Abstract: As chromatin immunoprecipitation (ChIP) sequencing is becoming the dominant technique for studying chromatin modifications, new protocols surface t... Read more »

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Bioruptor Antibody

Genetic variation at the 8q24.21 renal cancer susceptibility locus ...
Published: October, 2016

Abstract: Clear cell renal cell carcinoma (ccRCC) is characterized by loss of function of the von Hippel-Lindau tumour suppressor (VHL) and unrestrained acti... Read more »

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Bioruptor Antibody

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