Exploring the whole transcriptome allows to gain insight of potential transcriptional and regulatory network mechanisms. With Total RNA-seq services, we will sequence the whole transcriptome and record the complete set of RNA transcripts, including mRNAs and long non-coding RNAs, present in a biological sample under specific circumstances. This approach is optimal for finding biomarkers from known transcripts and discover new RNA features.
Our Epigenomics Profiling Services assure a fully integrated service-workflow for generation of RNA-seq libraries, multiplexed sequencing and data analysis. Serviced library preparation can be performed with an optional rRNA depletion step to enable cost-effective sequencing of RNA samples.
High discovery power with total RNA-seq
Detection of both coding and non-coding RNAs with optional rRNA depletion
Recognition of long coding RNAs involved in chromatin remodeling and transcriptional/post-transcriptional regulation
Investigation of the structure of genes, their splicing patterns and other post transcriptional modifications
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Long-term effects of myo-inositol on traumatic brain injury: Epigenomic and transcriptomic studies Oganezovi N. et al. Background and purpose
Traumatic brain injury (TBI) and its consequences remain great challenges for neurology. Consequences of TBI are associated with various alterations in the brain but little is known about long-term changes of epigenetic DNA methylation patterns. Moreover, nothing is known about potential trea...
Inflammatory stress-mediated chromatin changes underlie dysfunction in endothelial cells Liu H. et al. Inflammatory stresses underlie endothelial dysfunction and contribute to the development of chronic cardiovascular disorders such as atherosclerosis and vascular fibrosis. The initial transcriptional response of endothelial cells to pro-inflammatory cytokines such as TNF-alpha is well established. However, very few ...
