The DNA Methylation control package includes unmethylated and in vitro methylated DNA together with specific primer sets for assessing the efficiency of your Methylated DNA IP (MeDIP) [MeDIP application] carried out with Diagenode’s MeDIP, MagMeDIP and AutoMeDIP kits.
Methylated DNA immunoprecipitation
The Methylated DNA IP (MeDIP) is based on the affinity purification of methylated DNA using an antibody directed against 5-methylcytosine (5-mC) or 5-hydroxymethylcytosine (5-hmC) in the case of hMeDIP.
How it works
In brief, Methyl DNA IP is ... Read more
Diagenode strongly recommends using this: DNA Methylation control package (Diagenode Cat# C02040012). Click here to copy to clipboard.
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Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved Long HK, King HW, Patient RK, Odom DT, Klose RJ DNA methylation is a repressive epigenetic modification that covers vertebrate genomes. Regions known as CpG islands (CGIs), which are refractory to DNA methylation, are often associated with gene promoters and play central roles in gene regulation. Yet how CGIs in their normal genomic context evade the DNA methylat...
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