Publications

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1524 publications found×

Tiling histone H3 lysine 4 and 27 methylation in zebrafish using high-density microarrays.
Published: December, 2010

Abstract: BACKGROUND: Uncovering epigenetic states by chromatin immunoprecipitation and microarray hybridization (ChIP-chip) has significantly contributed to the understanding of gene regulation at the genome-scale level. Many studies have been carried out ...
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Antibody H3K4me3 (C15410003)

H2A.Z demarcates intergenic regions of the plasmodium falciparum epigenome that are dynamically marked by H3K9ac and H3K4me3.
Published: December, 2010

Abstract: Epigenetic regulatory mechanisms and their enzymes are promising targets for malaria therapeutic intervention; however, the epigenetic component of gene expression in P. falciparum is poorly understood. Dynamic or stable association of epigenetic ...
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DNA shearing Bioruptor Antibody

Histone H2A C-terminus regulates chromatin dynamics, remodeling, and histone H1 binding.
Published: December, 2010

Abstract: The tails of histone proteins are central players for all chromatin-mediated processes. Whereas the N-terminal histone tails have been studied extensively, little is known about the function of the H2A C-terminus. Here, we show that the H2A C-term...
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Antibody

ZNF274 recruits the histone methyltransferase SETDB1 to the 3' ends of ZNF genes.
Published: December, 2010

Abstract: Only a small percentage of human transcription factors (e.g. those associated with a specific differentiation program) are expressed in a given cell type. Thus, cell fate is mainly determined by cell type-specific silencing of transcription factor...
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Bioruptor Chromatin Shearing ChIP-seq Antibody

Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3.
Published: December, 2010

Abstract: The molecular mechanisms that direct transcription of the gene encoding the transcription factor Foxp3 in CD4(+) T cells remain ill-defined. We show here that deletion of the DNA-binding inhibitor Id3 resulted in the defective generation of Foxp3(...
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Antibody

STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells.
Published: November, 2010

Abstract: Peroxisome proliferator-activated receptor γ (PPARγ) is a lipid-activated transcription factor regulating lipid metabolism and inflammatory response in macrophages and dendritic cells (DCs). These immune cells exposed to distinct inflammatory mili...
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Antibody

A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.
Published: November, 2010

Abstract: Autism spectrum disorders (ASD) are complex neurodevelopmental diseases in which different combinations of genetic mutations may contribute to the phenotype. Using Rett syndrome (RTT) as an ASD genetic model, we developed a culture system using in...
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Antibody

Histone modifications at the blastocyst Axin1(Fu) locus mark the heritability of in vitro culture-induced epigenetic alterations in mice.
Published: November, 2010

Abstract: For epigenetic phenotypes to be passed on from one generation to the next, it is required that epigenetic marks between generations are not cleared during the two stages of epigenetic reprogramming: mammalian gametogenesis and preimplantation deve...
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Antibody LowCell ChIP kit

The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells.
Published: November, 2010

Abstract: The initiation of DNA synthesis is governed by the licensing of replication origins, which consists of assembling a pre-replication complex (pre-RC) on origins during late M- and G1-phases. In metazoans, functional replication origins do not show ...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody

Promoter-exon relationship of H3 lysine 9, 27, 36 and 79 methylation on pluripotency-associated genes.
Published: October, 2010

Abstract: Evidence links pluripotency to a gene regulatory network organized by the transcription factors Oct4, Nanog and Sox2. Expression of these genes is controlled by epigenetic modifications on regulatory regions. However, little is known on profiles o...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody

TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration.
Published: October, 2010

Abstract: How regeneration cues are converted into the epigenetic information that controls gene expression in adult stem cells is currently unknown. We identified an inflammation-activated signaling in muscle stem (satellite) cells, by which the polycomb r...
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Antibody

Methylation profiling in individuals with uniparental disomy identifies novel differentially methylated regions on chromosome 15.
Published: September, 2010

Abstract: The maternal and paternal genomes possess distinct epigenetic marks that distinguish them at imprinted loci. In order to identify imprinted loci, we used a novel method, taking advantage of the fact that uniparental disomy (UPD) provides a system ...
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Antibody

Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment.
Published: August, 2010

Abstract: Pluripotent cells develop within the inner cell mass of blastocysts, a mosaic of cells surrounded by an extra-embryonic layer, the trophectoderm. We show that a set of somatic lineage regulators (including Hox, Gata and Sox factors) that carry biv...
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Antibody

The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats
Published: July, 2010

Abstract: Maintenance of specific heterochromatic domains is crucial for genome stability. In eukaryotic cells, a fraction of the tandem-repeated ribosomal RNA (rRNA) genes is organized in the heterochromatic structures. The principal determinant of rDNA si...
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Antibody Master Mix

ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency.
Published: June, 2010

Abstract: Embryonic stem cells (ESCs) are pluripotent, self-renewing, and have the ability to reprogram differentiated cell types to pluripotency upon cellular fusion. Polycomb-group (PcG) proteins are important for restraining the inappropriate expression ...
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Antibody

Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping.
Published: June, 2010

Abstract: The current concept of epigenetic repression is based on one repressor unit corresponding to one silent gene. This notion, however, cannot adequately explain concurrent silencing of multiple loci observed in large chromosome regions. The long-rang...
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DNA shearing Chromatin Shearing ChIP-qPCR ChIP-seq Antibody 5mC (C15200081)

det1-1-induced UV-C hyposensitivity through UVR3 and PHR1 photolyase gene over-expression.
Published: May, 2010

Abstract: Summary Obligate photoautotrophs such as plants must capture energy from sunlight and are therefore exposed to the damaging collateral effects of ultraviolet (UV) irradiation, especially on DNA. Here we investigated the interconnection between lig...
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Antibody

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.
Published: April, 2010

Abstract: Demethylation at distinct lysine residues in histone H3 by lysine-specific demethylase 1 (LSD1) causes either gene repression or activation. As a component of co-repressor complexes, LSD1 contributes to target gene repression by removing mono- and...
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Antibody

A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly.
Published: April, 2010

Abstract: Chromodomain proteins (Chp1/Chp2/Swi6/Clr4) bind to methylated H3K9 (H3K9me) and regulate pericentric heterochromatin in fission yeast. Chp1 and Clr4 (H3K9-HMT), bind transcriptionally active heterochromatin, whereas Chp2/Swi6 (HP1 homologs) are r...
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Bioruptor Chromatin Shearing ChIP-qPCR Antibody

Autonomous silencing of the imprinted Cdkn1c gene in stem cells
Published: April, 2010

Abstract: Parent-of-origin specific expression of imprinted genes relies on the differential DNA methylation of specific genomic regions. Differentially methylated regions (DMRs) acquire DNA methylation either during gametogenesis (primary DMR) or after fer...
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Chromatin Shearing ChIP-qPCR Antibody H3K4me3 (C15410003) Histone ChIP kit

Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system.
Published: February, 2010

Abstract: A variety of chromatin remodeling complexes are thought to orchestrate transcriptional programs that lead neuronal precursors from earliest commitment to terminal differentiation. Here we show that mammalian neurons have a specialized chromatin re...
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Antibody

PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.
Published: February, 2010

Abstract: Many different molecular mechanisms have been associated with PML-RARalpha-dependent transformation of hematopoietic progenitors. Here, we identified high confidence PML-RARalpha binding sites in an acute promyelocytic leukemia (APL) cell line and...
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IP-Star Antibody RARalpha (C15310155)

Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z.
Published: February, 2010

Abstract: ATP-dependent chromatin remodeling complexes rearrange nucleosomes by altering the position of DNA around the histone octamer. Although chromatin remodelers and the histone variant H2A.Z colocalize on transcriptional control regions, whether H2A.Z...
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Antibody

AGRONOMICS1: a new resource for Arabidopsis transcriptome profiling.
Published: February, 2010

Abstract: Transcriptome profiling has become a routine tool in biology. For Arabidopsis (Arabidopsis thaliana), the Affymetrix ATH1 expression array is most commonly used, but it lacks about one-third of all annotated genes present in the reference strain. ...
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Bioruptor Chromatin Shearing Antibody LowCell ChIP kit

Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing.
Published: January, 2010

Abstract: BACKGROUND: Cancer cells undergo massive alterations to their DNA methylation patterns that result in aberrant gene expression and malignant phenotypes. However, the mechanisms that underlie methylome changes are not well understood nor is the gen...
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Antibody

The epigenetic landscape of latent Kaposi sarcoma-associated herpesvirus genomes.
Published: January, 2010

Abstract: Herpesvirus latency is generally thought to be governed by epigenetic modifications, but the dynamics of viral chromatin at early timepoints of latent infection are poorly understood. Here, we report a comprehensive spatial and temporal analysis o...
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DNA shearing Bioruptor Chromatin Shearing Antibody

In vivo chromatin organization of mouse rod photoreceptors correlates with histone modifications.
Published: January, 2010

Abstract: BACKGROUND: The folding of genetic information into chromatin plays important regulatory roles in many nuclear processes and particularly in gene transcription. Post translational histone modifications are associated with specific chromatin conden...
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Antibody

The core binding factor CBF negatively regulates skeletal muscle terminal differentiation.
Published: January, 2010

Abstract: BACKGROUND: Core Binding Factor or CBF is a transcription factor composed of two subunits, Runx1/AML-1 and CBF beta or CBFbeta. CBF was originally described as a regulator of hematopoiesis. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that CBF is ...
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Bioruptor Antibody

UPF2 is a critical regulator of liver development, function and regeneration.
Published: January, 2010

Abstract: BACKGROUND: Nonsense-mediated mRNA decay (NMD) is a post-transcriptional RNA surveillance process that facilitates the recognition and destruction of mRNAs bearing premature terminations codons (PTCs). Such PTC-containing (PTC+) mRNAs may arise fr...
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Antibody

Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated.
Published: January, 2010

Abstract: BACKGROUND: DNA methylation can regulate gene expression by modulating the interaction between DNA and proteins or protein complexes. Conserved consensus motifs exist across the human genome ("predicted transcription factor binding sites": "predic...
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DNA shearing Bioruptor Antibody

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