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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1524 publications found×
m3C is a mitochondrial mRNA modification which promotes tumor progression
Published: January, 2025
Abstract: Mitochondrial mRNA modifications are suggested to play a role in fine-tuning mitochondrial gene expression and function. However, the epitranscriptomic landscape of mitochondrial mRNA (mt-mRNA) remains poorly explored. Here, we uncover N3-methylcy...
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Antibody
Maternal obesity alters histone modifications mediated by the interaction between EZH2 and AMPK, impairing neural differentiation in the developing embryonic brain cortex
Published: January, 2025
Abstract: Neurodevelopmental disorders have complex origins that manifest early during embryonic growth and are associated with intricate gene regulation dynamics. A perturbed metabolic environment such as hyperglycemia or dyslipidemia, particularly due to ...
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Bioruptor Antibody
MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia
Published: January, 2025
Abstract: Enhancer translocations, due to 3q26 rearrangements, drive out-of-context MECOM expression in an aggressive subtype of acute myeloid leukemia (AML). Direct depletion of MECOM using an endogenous auxin-inducible degron immediately upregulates expre...
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Antibody Microplex Library Preparation kit
Exploring the Epigenetic Landscape of Spermatozoa: Impact of Oxidative Stress and Antioxidant Supplementation on DNA Methylation and Hydroxymethylation
Published: December, 2024
Abstract: Reproductive success is dependent on gamete integrity, and oxidative stress alters male nuclei, meaning that no DNA repair is possible due to chromatin compaction. The composition of sperm makes it highly sensitive to reactive oxygen species (ROS)...
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Antibody
EOMES establishes mesoderm and endoderm differentiation potential through SWI/SNF-mediated global enhancer remodeling
Published: December, 2024
Abstract: Highlights Enhancer chromatin is dynamically remodeled during mesoderm/endoderm (ME) differentiation Global ME enhancer accessibility during pluripotency exit relies on the Tbx factor EOMES EOMES and SWI/SNF cooperate ...
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Antibody iDeal ChIP-seq Kit for Transcription Factors
Interferon-gamma rescues FK506 dampened dendritic cell calcineurin-dependent responses to Aspergillus fumigatus via Stat3 to Stat1 switching
Published: December, 2024
Abstract: IScience Highlights Calcineurin inhibitors block DC maturation in response to A. fumigatus Lack of DC maturation impairs Th1 polarization in response to A. fumigatus Interferon-γ restores maturation, pr...
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Antibody IPure kit Microplex Library Preparation kit iDeal ChIP-seq Kit for Histones
Epi-microRNA mediated metabolic reprogramming counteracts hypoxia to preserve affinity maturation
Published: December, 2024
Abstract: To increase antibody affinity against pathogens, positively selected GC-B cells initiate cell division in the light zone (LZ) of germinal centers (GCs). Among these, higher-affinity clones migrate to the dark zone (DZ) and vigorously proliferate b...
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Microplex Library Preparation kit
NUP98 fusion proteins and KMT2A-MENIN antagonize PRC1.1 to drive gene expression in AML
Published: November, 2024
Abstract: Highlights Degradation of NUP98-fp halts nascent transcription of key oncogenes within 1 h NUP98-fp loss results in accumulation of PRC1.1 and repressive histone modifications PRC1.1 is needed for stable gene repress...
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Antibody
Peroxiredoxin 1-Toll-like receptor 4-p65 axis inhibits receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation
Published: November, 2024
Abstract: Peroxiredoxin 1 (PRDX1), an intracellular antioxidant enzyme, has emerged as a regulator of inflammatory responses via Toll-like receptor 4 (TLR4) signaling. Despite this, the mechanistic details of the PRDX1-TLR4 axis and its impact on osteoclast...
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Antibody
Nuclear localization of MTHFD2 is required for correct mitosis progression
Published: November, 2024
Abstract: Subcellular compartmentalization of metabolic enzymes establishes a unique metabolic environment that elicits specific cellular functions. Indeed, the nuclear translocation of certain metabolic enzymes is required for epigenetic regulation and gen...
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Antibody
Claudin-1 as a potential marker of stress-induced premature senescence in vascular smooth muscle cells
Published: November, 2024
Abstract: Cellular senescence, a permanent state of cell cycle arrest, can result either from external stress and is then called stress-induced premature senescence (SIPS), or from the exhaustion of cell division potential giving rise to replicative senesce...
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Antibody iDeal ChIP-seq Kit for Histones
A multidimensional recommendation framework for identifying biological targets to aid the diagnosis and treatment of liver metastasis in patients with colorectal cancer
Published: October, 2024
Abstract: The quest to understand the molecular mechanisms of tumour metastasis and identify pivotal biomarkers for cancer therapy is increasing in importance. Single-omics analyses, constrained by their focus on a single biological layer, cannot fully eluc...
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Antibody
GTSF1 is required for transposon silencing in the unicellular eukaryote Paramecium tetraurelia
Published: October, 2024
Abstract: The PIWI-interacting RNA (piRNA) pathway is crucial for transposon repression and the maintenance of genomic integrity. Gametocyte-specific factor 1 (GTSF1), a PIWI-associated protein indispensable for transposon repression, has been recently show...
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Antibody
Dysregulation of pseudouridylation in small RNAs contributes to papillary thyroid carcinoma metastasis
Published: October, 2024
Abstract: Background Previous studies have indicated that ψ-modified small RNAs play crucial roles in tumor metastasis. However, the ψ-modified small RNAs during metastasis of PTC are still unclear. Methods We compared the pseudouridine synthase ...
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Antibody
The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency
Published: October, 2024
Abstract: Background The epigenetic factors KAT6A (MOZ/MYST3) and KMT2A (MLL/MLL1) interact in normal hematopoiesis to regulate progenitors’ self-renewal. Both proteins are recurrently translocated in AML, leading to impairment of critical differenti...
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Antibody Microplex Library Preparation kit
Integrated multi-omics analysis of PBX1 in mouse adult neural stem- and progenitor cells identifies a transcriptional module that functionally links PBX1 to TCF3/4
Published: October, 2024
Abstract: Developmental transcription factors act in networks, but how these networks achieve cell- and tissue specificity is still poorly understood. Here, we explored pre-B cell leukemia homeobox 1 (PBX1) in adult neurogenesis combining genomic, transcrip...
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Antibody Microplex Library Preparation kit
5-Hydroxymethylcytosine in circulating cell-free DNA as a potential diagnostic biomarker for SLE
Published: October, 2024
Abstract: Background SLE is a complex autoimmune disease with heterogeneous manifestations and unpredictable outcomes. Early diagnosis is challenging due to non-specific symptoms, and current treatments only manage symptoms. Epigenetic alternations, ...
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Antibody
RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis
Published: October, 2024
Abstract: Mutation of tet methylcytosine dioxygenase 2 (encoded by TET2) drives myeloid malignancy initiation and progression1,2,3. TET2 deficiency is known to cause a globally opened chromatin state and activation of genes contributing to aberrant hae...
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Antibody
Trained immunity is regulated by T cell-induced CD40-TRAF6 signaling
Published: September, 2024
Abstract: Trained immunity is characterized by histone modifications and metabolic changes in innate immune cells following exposure to inflammatory signals, leading to heightened responsiveness to secondary stimuli. Although our understanding of the molecu...
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Antibody
Legionella pneumophila modulates macrophage functions through epigenetic reprogramming via the C-type lectin receptor Mincle
Published: September, 2024
Abstract: Legionella pneumophila is a pathogen which can lead to a severe form of pneumonia in humans known as Legionnaires disease after replication in alveolar macrophages. Viable L. pneumophila actively secrete effector molecules to m...
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Antibody
Single-cell multi-omics, spatial transcriptomics and systematic perturbation decode circuitry of neural crest fate decisions
Published: September, 2024
Abstract: Cranial neural crest (NC) cells, which can migrate, adopt multiple fates, and form most of the craniofacial skeleton, are an excellent model for studying cell fate decisions. Using time-resolved single-cell multi-omics, spatial transcriptomics, an...
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Antibody True MicroChIP kit
Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk
Published: September, 2024
Abstract: Genome-wide association studies of colorectal cancer (CRC) have identified 170 autosomal risk loci. However, for most of these, the functional variants and their target genes are unknown. Here, we perform statistical fine-mapping incorporating tis...
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Antibody
Bivalent chromatin accommodates survivin and BRG1/SWI complex to activate DNA damage response in CD4+ cells
Published: September, 2024
Abstract: Background Bivalent regions of chromatin (BvCR) are characterized by trimethylated lysine 4 (H3K4me3) and lysine 27 on histone H3 (H3K27me3) deposition which aid gene expression control during cell differentiation. The role of BvCR in post-...
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Antibody
RNA sequestration in P-bodies sustains myeloid leukaemia
Published: August, 2024
Abstract: Post-transcriptional mechanisms are fundamental safeguards of progenitor cell identity and are often dysregulated in cancer. Here, we identified regulators of P-bodies as crucial vulnerabilities in acute myeloid leukaemia (AML) through genome-wide...
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Antibody CUT&Tag
Human induced pluripotent stem cells for live cell cycle monitoring and endogenous gene activation
Published: August, 2024
Abstract: The fluorescence ubiquitination cell cycle inhibitor (FUCCI) has been introduced to monitor cell cycle activity in living cells, including human induced pluripotent stem cells (hiPSC) and derived cell types. We have recently developed hiPSC with s...
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Antibody CRISPR
LL37/self-DNA complexes mediate monocyte reprogramming
Published: August, 2024
Abstract: LL37 alone and in complex with self-DNA triggers inflammatory responses in myeloid cells and plays a crucial role in the development of systemic autoimmune diseases, like psoriasis and systemic lupus erythematosus. We demonstrated that LL37/self-D...
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Antibody
Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system
Published: July, 2024
Abstract: The reduced ability of the central nervous system to regenerate with increasing age limits functional recovery following demyelinating injury. Previous work has shown that myelin debris can overwhelm the metabolic capacity of microglia, thereby im...
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Antibody iDeal ChIP-seq Kit for Histones Chromatin Profiling (ChIP-seq) Services
A multiomic atlas of the aging hippocampus reveals molecular changes in response to environmental enrichment
Published: July, 2024
Abstract: Aging involves the deterioration of organismal function, leading to the emergence of multiple pathologies. Environmental stimuli, including lifestyle, can influence the trajectory of this process and may be used as tools in the pursuit of healthy ...
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Antibody Microplex Library Preparation kit iDeal ChIP-seq Kit for Histones
Loss of tumor suppressors promotes inflammatory tumor microenvironment and enhances LAG3+T cell mediated immune suppression
Published: July, 2024
Abstract: Low response rate, treatment relapse, and resistance remain key challenges for cancer treatment with immune checkpoint blockade (ICB). Here we report that loss of specific tumor suppressors (TS) induces an inflammatory response and promotes an imm...
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Antibody CRISPR
Epigenetic alterations affecting hematopoietic regulatory networks as drivers of mixed myeloid/lymphoid leukemia
Published: July, 2024
Abstract: Leukemias with ambiguous lineage comprise several loosely defined entities, often without a clear mechanistic basis. Here, we extensively profile the epigenome and transcriptome of a subgroup of such leukemias with CpG Island Methylator Phenotype....
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Antibody Microplex Library Preparation kit

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