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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1524 publications found×
AXR1 affects DNA methylation independently of its role in regulatingmeiotic crossover localization.
Published: June, 2020
Abstract: Meiotic crossovers (COs) are important for reshuffling genetic information between homologous chromosomes and they are essential for their correct segregation. COs are unevenly distributed along chromosomes and the underlying mechanisms controllin...
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Antibody
The 20S proteasome activator PA28γ controls the compaction of chromatin
Published: May, 2020
Abstract: The nuclear PA28γ is known to activate the 20S proteasome, but its precise cellular functions remains unclear. Here, we identify PA28γ as a key factor that structures heterochromatin. We find that in human cells, a fraction of PA28&gam...
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Antibody
Integration of high-throughput reporter assays identify a critical enhancer of the Ikzf1 gene.
Published: May, 2020
Abstract: The Ikzf1 locus encodes the lymphoid specific transcription factor Ikaros, which plays an essential role in both T and B cell differentiation, while deregulation or mutation of IKZF1/Ikzf1 is involved in leukemia. Tissue-specific and cell identity...
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Antibody
Measuring Histone Modifications in the Human Parasite Schistosoma mansoni
Published: May, 2020
Abstract: DNA-binding proteins play critical roles in many major processes such as development and sexual biology of Schistosoma mansoni and are important for the pathogenesis of schistosomiasis. Chromatin immunoprecipitation (ChIP) experiments followed by ...
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IP-Star Antibody
Histone post-translational modifications in Silene latifolia X and Y chromosomes suggest a mammal-like dosage compensation system
Published: May, 2020
Abstract: Silene latifolia is a model organism to study evolutionary young heteromorphic sex chromosome evolution in plants. Previous research indicates a Y-allele gene degeneration and a dosage compensation system already operating. Here, we propose an epi...
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Antibody
AP-1 controls the p11-dependent antidepressant response.
Published: May, 2020
Abstract: Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed drugs for mood disorders. While the mechanism of SSRI action is still unknown, SSRIs are thought to exert therapeutic effects by elevating extracellular serotonin level...
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Antibody Beads ChIP Cross-link Gold
2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer.
Published: May, 2020
Abstract: Despite the clinical success of Androgen Receptor (AR)-targeted therapies, reactivation of AR signalling remains the main driver of castration-resistant prostate cancer (CRPC) progression. In this study, we perform a comprehensive unbiased charact...
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Antibody IP-Star Compact
Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles.
Published: May, 2020
Abstract: Somatic stem cells expand massively during tissue regeneration, which might require control of cell fitness, allowing elimination of non-competitive, potentially harmful cells. How or if such cells are removed to restore organ function is not full...
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Antibody
β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1.
Published: May, 2020
Abstract: β-glucan is a potent inducer of epigenetic and functional reprogramming of innate immune cells, a process called "trained immunity," resulting in an enhanced host response against secondary infections. We investigate whether β-glucan exp...
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Antibody
DNA methylation enzymes and PRC1 restrict B-cell Epstein-Barr virus oncoprotein expression.
Published: May, 2020
Abstract: To accomplish the remarkable task of lifelong infection, the Epstein-Barr virus (EBV) switches between four viral genome latency and lytic programmes to navigate the B-cell compartment and evade immune responses. The transforming programme, consis...
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MagMeDIP kit Antibody
DNA methylation variation in the brain of laying hens in relation to differential behavioral patterns
Published: May, 2020
Abstract: Domesticated animals are unique to investigate the contribution of genetic and non-genetic factors to specific phenotypes. Among non-genetic factors involved in phenotype formation are epigenetic mechanisms. Here we aimed to identify whether relat...
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Antibody
MYC transcription activation mediated by OCT4 as a mechanism of resistance to 13-cisRA-mediated differentiation in neuroblastoma.
Published: May, 2020
Abstract: Despite the improvement in clinical outcome with 13-cis-retinoic acid (13-cisRA) + anti-GD2 antibody + cytokine immunotherapy given in first response ~40% of high-risk neuroblastoma patients die of recurrent disease. MYCN genomic amplification is ...
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iDeal ChIP-seq Kit for Transcription Factors
TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment.
Published: May, 2020
Abstract: The acquisition of cell identity is associated with developmentally regulated changes in the cellular histone methylation signatures. For instance, commitment to neural differentiation relies on the tightly controlled gain or loss of H3K27me3, a h...
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Antibody
Homer1a Undergoes Bimodal Transcriptional Regulation by CREB and the Circadian Clock.
Published: May, 2020
Abstract: Accumulating evidence points to a significant link between disrupted circadian rhythms and neuronal disfunctions, though the molecular mechanisms underlying this connection are virtually unexplored. The transcript Homer1a, an immediate early gene ...
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Antibody
Revisiting promyelocytic leukemia protein targeting by human cytomegalovirus immediate-early protein 1.
Published: May, 2020
Abstract: Promyelocytic leukemia (PML) bodies are nuclear organelles implicated in intrinsic and innate antiviral defense. The eponymous PML proteins, central to the self-organization of PML bodies, and other restriction factors found in these organelles ar...
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Antibody
In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states.
Published: May, 2020
Abstract: Following implantation, the naive pluripotent epiblast of the mouse blastocyst generates a rosette, undergoes lumenogenesis and forms the primed pluripotent egg cylinder, which is able to generate the embryonic tissues. How pluripotency progressio...
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Antibody
The domesticated transposase ALP2 mediates formation of a novel Polycomb protein complex by direct interaction with MSI1, a core subunit of Polycomb Repressive Complex 2 (PRC2).
Published: May, 2020
Abstract: A large fraction of plant genomes is composed of transposable elements (TE), which provide a potential source of novel genes through "domestication"-the process whereby the proteins encoded by TE diverge in sequence, lose their ability to catalyse...
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Antibody
Genomic Profiling by ALaP-Seq Reveals Transcriptional Regulation by PML Bodies through DNMT3A Exclusion.
Published: April, 2020
Abstract: The promyelocytic leukemia (PML) body is a phase-separated nuclear structure physically associated with chromatin, implying its crucial roles in genome functions. However, its role in transcriptional regulation is largely unknown. We developed APE...
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Antibody
Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.
Published: April, 2020
Abstract: Tissue-resident and recruited macrophages contribute to both host defense and pathology. Multiple macrophage phenotypes are represented in diseased tissues, but we lack deep understanding of mechanisms controlling diversification. Here, we investi...
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Antibody
SETDB2 promoted breast cancer stem cell maintenance by interaction with and stabilization of ΔNp63α protein
Published: April, 2020
Abstract: The histone H3K9 methyltransferase SETDB2 is involved in cell cycle dysregulation in acute leukemia and has oncogenic roles in gastric cancer. In our study, we found that SETDB2 plays essential roles in breast cancer stem cell maintenance. Deplete...
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Antibody
Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction.
Published: April, 2020
Abstract: Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)physiology. Aging is the major risk factor for cardiovascular disease with cardiomyocyte apoptosis as one underlying cause. Here, we report the identification of the aging-regulated lncRN...
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Antibody Beads
Non-coding somatic mutations converge on the PAX8 pathway in ovarian cancer.
Published: April, 2020
Abstract: The functional consequences of somatic non-coding mutations in ovarian cancer (OC) are unknown. To identify regulatory elements (RE) and genes perturbed by acquired non-coding variants, here we establish epigenomic and transcriptomic landscapes of...
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Antibody
An epigenetic map of malaria parasite development from host to vector.
Published: April, 2020
Abstract: The malaria parasite replicates asexually in the red blood cells of its vertebrate host employing epigenetic mechanisms to regulate gene expression in response to changes in its environment. We used chromatin immunoprecipitation followed by sequen...
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Antibody
The TGF-β profibrotic cascade targets ecto-5'-nucleotidase gene in proximal tubule epithelial cells and is a traceable marker of progressive diabetic kidney disease.
Published: April, 2020
Abstract: Progressive diabetic nephropathy (DN) and loss of renal function correlate with kidney fibrosis. Crosstalk between TGF-β and adenosinergic signaling contributes to the phenotypic transition of cells and to renal fibrosis in DN models. We eval...
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Antibody
Abo1 is required for the H3K9me2 to H3K9me3 transition in heterochromatin.
Published: April, 2020
Abstract: Heterochromatin regulation is critical for genomic stability. Different H3K9 methylation states have been discovered, with distinct roles in heterochromatin formation and silencing. However, how the transition from H3K9me2 to H3K9me3 is controlled...
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Antibody
Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia
Published: April, 2020
Abstract: Acute myeloid leukemia (AML) is a highly aggressive hematopoietic malignancy, defined by a series of genetic and epigenetic alterations, which result in deregulation of transcriptional networks. One understudied but important source of transcripti...
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Antibody
TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition.
Published: March, 2020
Abstract: Loss-of-function mutations in the SDHB subunit of succinate dehydrogenase predispose patients to aggressive tumors characterized by pseudohypoxic and hypermethylator phenotypes. The mechanisms leading to DNA hypermethylation and its cont...
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MagMeDIP kit Antibody iDeal ChIP-qPCR
CRISPR-based gene knockout screens reveal deubiquitinases involved in HIV-1 latency in two Jurkat cell models.
Published: March, 2020
Abstract: The major barrier to a HIV-1 cure is the persistence of latent genomes despite treatment with antiretrovirals. To investigate host factors which promote HIV-1 latency, we conducted a genome-wide functional knockout screen using CRISPR-Cas9 in a HI...
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Antibody CRISPR
Differential modulation of the androgen receptor for prostate cancer therapy depends on the DNA response element.
Published: March, 2020
Abstract: Androgen receptor (AR) action is a hallmark of prostate cancer (PCa) with androgen deprivation being standard therapy. Yet, resistance arises and aberrant AR signaling promotes disease. We sought compounds that inhibited genes driving cancer but n...
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Antibody IPure kit
High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase.
Published: March, 2020
Abstract: Cellular levels of ribonucleoside triphosphates (rNTPs) are much higher than those of deoxyribonucleoside triphosphates (dNTPs), thereby influencing the frequency of incorporation of ribonucleoside monophosphates (rNMPs) by DNA polymerases (Pol) i...
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Antibody

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