Diagenode
| United States | My cart | 登录 / 注册 搜索

Publications

Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
miR-155 inhibits mitophagy through suppression of BAG5, a partner protein of PINK1.
Published: January, 2020
Abstract: Removal of dysfunctional mitochondria is essential step to maintain normal cell physiology, and selective autophagy in mitochondria, called mitophagy, plays a critical role in quality control of mitochondria. While in several diseases and aging, d...
Read more »
Tags
Antibody
AP-1 activity induced by co-stimulation is required for chromatin opening during T cell activation.
Published: January, 2020
Abstract: Activation of T cells is dependent on the organized and timely opening and closing of chromatin. Herein, we identify AP-1 as the transcription factor that directs most of this remodeling. Chromatin accessibility profiling showed quick opening of c...
Read more »
Tags
IP-Star Antibody
A comprehensive epigenomic analysis of phenotypically distinguishable, genetically identical female and male Daphnia pulex.
Published: January, 2020
Abstract: BACKGROUND: Daphnia species reproduce by cyclic parthenogenesis involving both sexual and asexual reproduction. The sex of the offspring is environmentally determined and mediated via endocrine signalling by the mother. Interestingly, male and fem...
Read more »
Tags
Antibody Microplex Library Preparation kit iDeal ChIP-seq Kit for Histones Chromatin Profiling (ChIP-seq) Services
Analysis of Histone Modifications in Rodent Pancreatic Islets by Native Chromatin Immunoprecipitation.
Published: January, 2020
Abstract: The islets of Langerhans are clusters of cells dispersed throughout the pancreas that produce several hormones essential for controlling a variety of metabolic processes, including glucose homeostasis and lipid metabolism. Studying the transcripti...
Read more »
Tags
Antibody
TIP60/P400/H4K12ac Plays a Role as a Heterochromatin Back-up Skeleton inBreast Cancer.
Published: January, 2020
Abstract: BACKGROUND/AIM: In breast cancer, initiation of carcinogenesis leads to epigenetic dysregulation, which can lead for example to the loss of the heterochromatin skeleton SUV39H1/H3K9me3/HP1 or the supposed secondary skeleton TIP60/P400/H4K12ac/BRD ...
Read more »
Tags
Antibody iDeal ChIP-seq Kit for Histones
Changes in H3K27ac at Gene Regulatory Regions in Porcine AlveolarMacrophages Following LPS or PolyIC Exposure.
Published: January, 2020
Abstract: Changes in chromatin structure, especially in histone modifications (HMs), linked with chromatin accessibility for transcription machinery, are considered to play significant roles in transcriptional regulation. Alveolar macrophages (AM) are impor...
Read more »
Tags
Antibody iDeal ChIP-seq Kit for Histones
The Inhibition of the Histone Methyltransferase EZH2 by DZNEP or SiRNA Demonstrates Its Involvement in MGMT, TRA2A, RPS6KA2, and U2AF1 Gene Regulation in Prostate Cancer.
Published: December, 2019
Abstract: In France, prostate cancer is the most common cancer in men (Bray et al., 2018). Previously, our team has reported the involvement of epigenetic factors in prostate cancer (Ngollo et al., 2014, 2017). The histone 3 lysine 27 trimethylation (H3K27m...
Read more »
Tags
Antibody
Charting the cis-regulome of activated B cells by coupling structural and functional genomics.
Published: December, 2019
Abstract: Cis-regulomes underlying immune-cell-specific genomic states have been extensively analyzed by structure-based chromatin profiling. By coupling such approaches with a high-throughput enhancer screen (self-transcribing active regulatory region sequ...
Read more »
Tags
Antibody
Unraveling the role of H3K4 trimethylation and lncRNA HOTAIR in SATB1 and DUSP4-dependent survival of virulent Mycobacterium tuberculosis in macrophages
Published: December, 2019
Abstract: The modification of chromatin influences host transcriptional programs during bacterial infection, at times skewing the balance in favor of pathogen survival. To test the role of chromatin modifications during Mycobacterium tuberculosis infection,...
Read more »
Tags
Antibody iDeal ChIP-seq Kit for Histones
Allelic H3K27me3 to allelic DNA methylation switch maintains noncanonical imprinting in extraembryonic cells
Published: December, 2019
Abstract: Faithful maintenance of genomic imprinting is essential for mammalian development. While germline DNA methylation–dependent (canonical) imprinting is relatively stable during development, the recently found oocyte-derived H3K27me3-mediated n...
Read more »
Tags
Antibody
Functionally Annotating Regulatory Elements in the Equine Genome Using Histone Mark ChIP-Seq.
Published: December, 2019
Abstract: One of the primary aims of the Functional Annotation of ANimal Genomes (FAANG) initiative is to characterize tissue-specific regulation within animal genomes. To this end, we used chromatin immunoprecipitation followed by sequencing (ChIP-Seq) to ...
Read more »
Tags
Antibody IP-Star Compact Microplex Library Preparation kit iDeal ChIP-seq Kit for Histones Chromatin Profiling (ChIP-seq) Services
H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation.
Published: December, 2019
Abstract: Natural killer (NK) cells are unique players in innate immunity and, as such, an attractive target for immunotherapy. NK cells display immune memory properties in certain models, but the long-term status of NK cells following systemic inflammation...
Read more »
Tags
Antibody
Inhibition of Histone Demethylases LSD1 and UTX Regulates ERα Signaling in Breast Cancer.
Published: December, 2019
Abstract: In breast cancer, Lysine-specific demethylase-1 (LSD1) and other lysine demethylases (KDMs), such as Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), are co-expressed and co-locali...
Read more »
Tags
Antibody
Trained immunity modulates inflammation-induced fibrosis.
Published: December, 2019
Abstract: Chronic inflammation and fibrosis can result from inappropriately activated immune responses that are mediated by macrophages. Macrophages can acquire memory-like characteristics in response to antigen exposure. Here, we show the effect of BCG or ...
Read more »
Tags
Antibody iDeal ChIP-seq Kit for Histones
Mkt1 is required for RNAi-mediated silencing and establishment of heterochromatin in fission yeast.
Published: December, 2019
Abstract: Constitutive domains of repressive heterochromatin are maintained within the fission yeast genome through self-reinforcing mechanisms involving histone methylation and small RNAs. Non-coding RNAs generated from heterochromatic regions are processe...
Read more »
Tags
Antibody
A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development.
Published: December, 2019
Abstract: Fallopian tube secretory epithelial cells (FTSECs) are likely the main precursor cell type of high-grade serous ovarian cancers (HGSOCs), but these tumors may also arise from ovarian surface epithelial cells (OSECs). We profiled global landscapes ...
Read more »
Tags
Antibody
USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer.
Published: December, 2019
Abstract: As a member of the 11-gene "death-from-cancer" gene expression signature, overexpression of the Ubiquitin-Specific Protease 22 (USP22) was associated with poor prognosis in various human malignancies. To investigate the function of USP22 in cancer...
Read more »
Tags
Antibody
SIRT1/2 orchestrate acquisition of DNA methylation and loss of histone H3 activating marks to prevent premature activation of inflammatory genes in macrophages.
Published: December, 2019
Abstract: Sirtuins 1 and 2 (SIRT1/2) are two NAD-dependent deacetylases with major roles in inflammation. In addition to deacetylating histones and other proteins, SIRT1/2-mediated regulation is coupled with other epigenetic enzymes. Here, we investigate th...
Read more »
Tags
Antibody LowCell ChIP kit
Sodium valproate and 5-aza-2'-deoxycytidine differentially modulate DNA demethylation in G1 phase-arrested and proliferative HeLa cells.
Published: December, 2019
Abstract: Sodium valproate/valproic acid (VPA), a histone deacetylase inhibitor, and 5-aza-2-deoxycytidine (5-aza-CdR), a DNA methyltransferase 1 (DNMT1) inhibitor, induce DNA demethylation in several cell types. In HeLa cells, although VPA leads to decreas...
Read more »
Tags
Antibody
Episo: quantitative estimation of RNA 5-methylcytosine at isoform level by high-throughput sequencing of RNA treated with bisulfite.
Published: December, 2019
Abstract: MOTIVATION: RNA 5-methylcytosine (m5C) is a type of post-transcriptional modification that may be involved in numerous biological processes and tumorigenesis. RNA m5C can be profiled at single-nucleotide resolution by high-throughput sequencing of...
Read more »
Tags
Antibody
MicroRNA-708 is a novel regulator of the Hoxa9 program in myeloid cells.
Published: November, 2019
Abstract: MicroRNAs (miRNAs) are commonly deregulated in acute myeloid leukemia (AML), affecting critical genes not only through direct targeting, but also through modulation of downstream effectors. Homeobox (Hox) genes balance self-renewal, proliferation,...
Read more »
Tags
Antibody
Intra- and inter-generational changes in the cortical DNA methylome in response to therapeutic intermittent hypoxia in mice.
Published: November, 2019
Abstract: Recent evidence from our lab documents functional resilience to retinal ischemic injury in untreated mice derived from parents exposed to repetitive hypoxic conditioning (RHC) prior to breeding. To begin to understand the epigenetic basis of this ...
Read more »
Tags
Antibody
R-Loops Promote Antisense Transcription across the Mammalian Genome
Published: November, 2019
Abstract: Widespread antisense long noncoding RNA (lncRNA) overlap with many protein-coding genes in mammals and emanate from gene promoter, enhancer, and termination regions. However, their origin and biological purpose remain unclear. We show that these a...
Read more »
Tags
Antibody
Autoregulation of RCO by Low-Affinity Binding Modulates Cytokinin Action and Shapes Leaf Diversity.
Published: November, 2019
Abstract: Mechanisms through which the evolution of gene regulation causes morphological diversity are largely unclear. The tremendous shape variation among plant leaves offers attractive opportunities to address this question. In cruciferous plants, the RE...
Read more »
Tags
Antibody
CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer.
Published: November, 2019
Abstract: Androgen-receptor (AR) inhibitors, including enzalutamide, are used for treatment of all metastatic castration-resistant prostate cancers (mCRPCs). However, some patients develop resistance or never respond. We find that the transcription factor C...
Read more »
Tags
Antibody
Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling.
Published: November, 2019
Abstract: Mammalian switch/sucrose non-fermentable (mSWI/SNF) complexes are multi-component machines that remodel chromatin architecture. Dissection of the subunit- and domain-specific contributions to complex activities is needed to advance mechanistic und...
Read more »
Tags
Antibody
MicroRNAs Establish the Right-Handed Dominance of the Heart Laterality Pathway in Vertebrates
Published: November, 2019
Abstract: Despite their external bilateral symmetry, vertebrates have internal left/right (L/R) asymmetries required for optimal organ function. BMP-induced epithelial to mesenchymal transition (EMT) in the lateral plate mesoderm (LPM) triggers L/R asymmetr...
Read more »
Tags
Antibody
Lithium treatment reverses irradiation-induced changes in rodent neural progenitors and rescues cognition.
Published: November, 2019
Abstract: Cranial radiotherapy in children has detrimental effects on cognition, mood, and social competence in young cancer survivors. Treatments harnessing hippocampal neurogenesis are currently of great relevance in this context. Lithium, a well-known mo...
Read more »
Tags
MagMeDIP kit Antibody
Sperm DNA Methylation Epimutation Biomarkers for Male Infertility and FSH Therapeutic Responsiveness.
Published: November, 2019
Abstract: Male factor infertility is increasing and recognized as playing a key role in reproductive health and disease. The current primary diagnostic approach is to assess sperm quality associated with reduced sperm number and motility, which has been his...
Read more »
Tags
Antibody
Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner.
Published: November, 2019
Abstract: How cytokine-driven changes in chromatin topology are converted into gene regulatory circuits during inflammation still remains unclear. Here, we show that interleukin (IL)-1α induces acute and widespread changes in chromatin accessibility v...
Read more »
Tags
Antibody

活动

  • QMUL Centre for Epigenetics Launch Conference 2025
    London, UK
    Jun 4, 2025
 查看所有活动

 

       Site map   |   Contact us   |   Conditions of sales   |   Conditions of purchase   |   Privacy policy