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Explore Diagenode’s publication database. Learn how our products are used in diverse fields of research.

1474 publications found×
Promoter-interacting expression quantitative trait loci are enriched forfunctional genetic variants.
Published: December, 2020
Abstract: Expression quantitative trait loci (eQTLs) studies provide associations of genetic variants with gene expression but fall short of pinpointing functionally important eQTLs. Here, using H3K27ac HiChIP assays, we mapped eQTLs overlapping active cis-...
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Antibody
Quantification and epigenetic evaluation of the residual pool of hepatitisB covalently closed circular DNA in long-term nucleoside analogue-treatedpatients.
Published: December, 2020
Abstract: Hepatitis B virus (HBV) covalently closed circular (ccc)DNA is the key genomic form responsible for viral persistence and virological relapse after treatment withdrawal. The assessment of residual intrahepatic cccDNA levels and activity after long...
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Bioruptor Antibody
Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis.
Published: December, 2020
Abstract: Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and show exquisite regional and temporal specificity, suggesting a developmental context permissive to their effects. Here we show that 50\% of G34R/V tumors (n&nbs...
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Antibody IP-Star Compact iDeal ChIP-seq Kit for Histones
S-adenosyl-l-homocysteine hydrolase links methionine metabolism to thecircadian clock and chromatin remodeling.
Published: December, 2020
Abstract: Circadian gene expression driven by transcription activators CLOCK and BMAL1 is intimately associated with dynamic chromatin remodeling. However, how cellular metabolism directs circadian chromatin remodeling is virtually unexplored. We report tha...
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Antibody
EZH2 and KDM6B Expressions Are Associated with Specific EpigeneticSignatures during EMT in Non Small Cell Lung Carcinomas.
Published: December, 2020
Abstract: The role of Epigenetics in Epithelial Mesenchymal Transition (EMT) has recently emerged. Two epigenetic enzymes with paradoxical roles have previously been associated to EMT, EZH2 (Enhancer of Zeste 2 Polycomb Repressive Complex 2 (PRC2) Subunit),...
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IP-Star Antibody iDeal ChIP-seq Kit for Histones
TGFβ promotes widespread enhancer chromatin opening and operates ongenomic regulatory domains.
Published: December, 2020
Abstract: The Transforming Growth Factor-β (TGFβ) signaling pathway controls transcription by regulating enhancer activity. How TGFβ-regulated enhancers are selected and what chromatin changes are associated with TGFβ-dependent enhancers...
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Antibody CRISPR
PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across thezygote genome.
Published: December, 2020
Abstract: The formation of zygote is the beginning of mammalian life, and dynamic epigenetic modifications are essential for mammalian normal development. H3K27 di-methylation (H3K27me2) and H3K27 tri-methylation (H3K27me3) are marks of facultative het...
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Antibody
Kaposi’s Sarcoma-Associated Herpesvirus Processivity Factor,ORF59, Binds to Canonical and Linker Histones, and ItsCarboxy Terminus Is Dispensable for Viral DNA Synthesis
Published: December, 2020
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus and the causative agent of potentially fatal malignancies. Lytic replication of KSHV is an essential part of the viral life cycle, allowing for virus dissemination within t...
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Antibody iDeal ChIP-seq Kit for Histones
Enhancer hijacking determines extrachromosomal circular MYCN ampliconarchitecture in neuroblastoma.
Published: November, 2020
Abstract: MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene copies are commonly found on highly rearranged, extrachromosomal circular DNA (ecDNA). The exact amplicon structure has not been described thus far and the functio...
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Antibody
Epigenome-wide association study for pesticide (Permethrin and DEET)induced DNA methylation epimutation biomarkers for specifictransgenerational disease.
Published: November, 2020
Abstract: BACKGROUND: Permethrin and N,N-diethyl-meta-toluamide (DEET) are the pesticides and insect repellent most commonly used by humans. These pesticides have been shown to promote the epigenetic transgenerational inheritance of disease in rats. The cur...
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Antibody
Dissecting Herpes Simplex Virus 1-Induced Host Shutoff at the RNA Level.
Published: November, 2020
Abstract: Herpes simplex virus 1 (HSV-1) induces a profound host shut-off during lytic infection. The virion host shut-off () protein plays a key role in this process by efficiently cleaving host and viral mRNAs. Furthermore, the onset of viral DNA replicat...
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Antibody
Increased H3K4me3 methylation and decreased miR-7113-5p expression lead toenhanced Wnt/β-catenin signaling in immune cells from PTSD patientsleading to inflammatory phenotype.
Published: November, 2020
Abstract: BACKGROUND: Posttraumatic stress disorder (PTSD) is a psychiatric disorder accompanied by chronic peripheral inflammation. What triggers inflammation in PTSD is currently unclear. In the present study, we identified potential defects in signaling ...
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Antibody True MicroChIP kit
A histone H3.3K36M mutation in mice causes an imbalance of histonemodifications and defects in chondrocyte differentiation.
Published: November, 2020
Abstract: Histone lysine-to-methionine (K-to-M) mutations have been identified as driver mutations in human cancers. Interestingly, these 'oncohistone' mutations inhibit the activity of histone methyltransferases. Therefore, they can potentially be used as ...
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Antibody
BCG Vaccination Induces Long-Term Functional Reprogramming of HumanNeutrophils.
Published: November, 2020
Abstract: The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune memory in monocytes and natural killer (NK) cells, a process known as trained immuni...
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Antibody
TRF2 Mediates Replication Initiation within Human Telomeres to PreventTelomere Dysfunction.
Published: November, 2020
Abstract: The telomeric shelterin protein telomeric repeat-binding factor 2 (TRF2) recruits origin recognition complex (ORC) proteins, the foundational building blocks of DNA replication origins, to telomeres. We seek to determine whether TRF2-recruited ORC...
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Antibody
MEAF6 is essential for cell proliferation and plays a role in theassembly of KAT7 complexes.
Published: November, 2020
Abstract: Myst family genes encode lysine acetyltransferases that mainly mediate histone acetylation to control transcription, DNA replication and DNA damage response. They form tetrameric complexes with PHD-finger proteins (Brpfs or Jades) and small non-ca...
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Antibody
CDK4/6 inhibition reprograms the breast cancer enhancer landscape bystimulating AP-1 transcriptional activity
Published: November, 2020
Abstract: Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) were designed to induce cancer cell cycle arrest. Recent studies have suggested that these agents also exert other effects, influencing cancer cell immunogenicity, apoptotic res...
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Antibody
ZNF354C is a transcriptional repressor that inhibits endothelialangiogenic sprouting.
Published: November, 2020
Abstract: Zinc finger proteins (ZNF) are a large group of transcription factors with diverse functions. We recently discovered that endothelial cells harbour a specific mechanism to limit the action of ZNF354C, whose function in endothelial cells is unknown...
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Antibody Beads
Derivation of Intermediate Pluripotent Stem Cells Amenable to PrimordialGerm Cell Specification.
Published: November, 2020
Abstract: Dynamic pluripotent stem cell (PSC) states are in vitro adaptations of pluripotency continuum in vivo. Previous studies have generated a number of PSCs with distinct properties. To date, however, no known PSCs have demonstrated dual comp...
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Antibody iDeal ChIP-seq Kit for Histones
The epigenetic regulator RINF (CXXC5) maintains SMAD7 expression in human immature erythroid cells and sustains red blood cellsexpansion.
Published: November, 2020
Abstract: The gene CXXC5, encoding a Retinoid-Inducible Nuclear Factor (RINF), is located within a region at 5q31.2 commonly deleted in myelodysplastic syndrome (MDS) and adult acute myeloid leukemia (AML). RINF may act as an epigenetic regulator and has be...
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Bioruptor Antibody iDeal ChIP-seq Kit for Transcription Factors
Trans- and cis-acting effects of Firre on epigenetic features of theinactive X chromosome.
Published: November, 2020
Abstract: Firre encodes a lncRNA involved in nuclear organization. Here, we show that Firre RNA expressed from the active X chromosome maintains histone H3K27me3 enrichment on the inactive X chromosome (Xi) in somatic cells. This trans-acting effect involve...
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Antibody Microplex Library Preparation kit True MicroChIP kit
ΔNp63 is a pioneer factor that binds inaccessible chromatin and elicitchromatin remodeling
Published: November, 2020
Abstract: Background: ΔNp63 is a master transcriptional regulator playing critical roles in epidermal development and other cellular processes. Recent studies suggest that ΔNp63 functions as a pioneer factor that can target its binding sites wit...
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Antibody iDeal ChIP-seq Kit for Transcription Factors
The histone H2B ubiquitin ligase RNF40 is required for HER2-drivenmammary tumorigenesis.
Published: October, 2020
Abstract: The HER2-positive breast cancer subtype (HER2-BC) displays a particularly aggressive behavior. Anti-HER2 therapies have significantly improved the survival of patients with HER2-BC. However, a large number of patients become refractory to current ...
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Antibody Microplex Library Preparation kit
StE(z)2, a Polycomb group methyltransferase and deposition of H3K27me3 andH3K4me3 regulate the expression of tuberization genes in potato.
Published: October, 2020
Abstract: Polycomb Repressive Complex (PRC) group proteins regulate various developmental processes in plants by repressing the target genes via H3K27 trimethylation, whereas their function is antagonized by Trithorax group proteins-mediated H3K4 trimethyla...
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Antibody
Priming for enhanced ARGONAUTE2 activation accompanies induced resistanceto cucumber mosaic virus in Arabidopsis thaliana.
Published: October, 2020
Abstract: Systemic acquired resistance (SAR) is a broad-spectrum disease resistance response that can be induced upon infection from pathogens or by chemical treatment, such as with benzo-(1,2,3)-thiadiazole-7-carbothioic acid S-methyl ester (BTH). SAR invo...
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Antibody
Digging Deeper into Breast Cancer Epigenetics: Insights from ChemicalInhibition of Histone Acetyltransferase TIP60 .
Published: October, 2020
Abstract: Breast cancer is often sporadic due to several factors. Among them, the deregulation of epigenetic proteins may be involved. TIP60 or KAT5 is an acetyltransferase that regulates gene transcription through the chromatin structure. This pleiotropic ...
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Antibody IP-Star Compact iDeal ChIP-seq Kit for Histones
NSD1-deposited H3K36me2 directs de novo methylation in the mouse malegermline and counteracts Polycomb-associated silencing.
Published: October, 2020
Abstract: De novo DNA methylation (DNAme) in mammalian germ cells is dependent on DNMT3A and DNMT3L. However, oocytes and spermatozoa show distinct patterns of DNAme. In mouse oocytes, de novo DNAme requires the lysine methyltransferase (KMTase) SETD2, whic...
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Antibody
MITF is a driver oncogene and potential therapeutic target in kidneyangiomyolipoma tumors through transcriptional regulation of CYR61.
Published: October, 2020
Abstract: Tuberous sclerosis complex (TSC) is an autosomal dominant tumor suppressor syndrome, characterized by tumor development in multiple organs, including renal angiomyolipoma. Biallelic loss of TSC1 or TSC2 is a known genetic driver of angiomyolipoma ...
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Antibody
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth andPotentiates Checkpoint Inhibition.
Published: October, 2020
Abstract: Trained immunity, a functional state of myeloid cells, has been proposed as a compelling immune-oncological target. Its efficient induction requires direct engagement of myeloid progenitors in the bone marrow. For this purpose, we developed a bone...
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Antibody
Epigenetic Blockade of Hippocampal SOD2 Via DNMT3b-Mediated DNAMethylation: Implications in Mild Traumatic Brain Injury-Induced PersistentOxidative Damage.
Published: October, 2020
Abstract: The recurrent events of mild trauma exacerbate the vulnerability for post-traumatic stress disorder; however, the underlying molecular mechanisms are scarcely known. The repeated mild traumatic brain injury (rMTBI) perturbs redox homeostasis which...
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Antibody

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