Diagenode Ago monoclonal antibody (Cat No. C15200167) immunoprecipitates the predicted miRNA target alleles very efficientlyHaruko Takeda, University of Liège, Belgium
Alternative names: ZEIF2C2, PPD, q10
Members of the Argonaute (Ago) protein family are central to RISC function. Argonaute proteins bind to mature microRNA (miRNAs) and short interfering RNAs (siRNAs) and form the core components of effector complexes that mediate miRNA and siRNA function. Argonautes are needed for miRNA-induced silencing and contain two conserved RNA binding domains: a PAZ domain that can bind the single stranded 3’ end of the mature miRNA and a PIWI domain that structurally resembles ribonuclease-H and functions to interact with the 5’ end of the guide strand.
|Species reactivity||Human, mouse, other (wide range)|
|Purity||Protein A purified|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|IP (RIP)||8 μg||Fig 1, Ref 1|